曹 彬 教授/博导


学科（方向）：生殖生物学与生殖医学
所在系部：生殖调控与生殖健康研究福建省高等学校重点实验室
邮 箱：caobin19@xmu.edu.cn



研究领域：
胎盘是妊娠过程中发挥重要作用的临时性内分泌器官，直接介导了母体与胎儿之间的“对话”。胎盘也是目前研究最不透彻的器官之一，由其异常发育以及功能失衡导致妊娠相关疾病发病的机制尚不明确。曹彬博士近十年来一直从事胎盘发育及功能调控的分子机制以及妊娠疾病发病机理研究，曾在Cell、JEM、JCI Insight、Nature、Nature Immunology及Cell Host& Microbe等权威学术杂志发表研究论文近二十篇。曾荣获SRI Laxmi Baxi Award（2016）及2017 年度STAT Wunderkinds等多项国际学术奖励。实验室主要研究方向为：1）胎盘早期发育的细胞分子调控机制；2）致病微生物与宿主在母胎界面的相互作用及母胎传播机制；3）子痫前期及早产等重大妊娠疾病发病机理。
学习经历：
2000~2004山西大学生物科学专业 理学学士；
2005~2011中国科学院动物研究所发育生物学专业理学博士士；
工作经历：
2011~2018圣路易斯华盛顿大学 博士后；
2018~至今厦门大学医学院 教授；
代表性成果：
1. Miner JJ*, Cao B*,Govero J,Smith AM,Fernandez E,Cabrera OH,Garber C,Noll M,Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell. 165, 1081-91 (2016). (*Co-first author).
2. Cao B, Parnell LA, Diamond MS, Mysorekar I.U. Inhibition of autophagy limits verticaltransmission of Zika virusin pregnant mice. J Exp Med.7;214(8):2303-2313 (2017).
3. Cao B, Macones C, Mysorekar IU. ATG16L1 governs the placental syncytial barrier to infection and risk of premature birth in pregnant mice and women. JCI Insight. e86654 (2016).
4. Fernandez E, Dejnirattisai W, Cao B,Scheaffer SM, Supasa P, Wongwiwat W, Esakky P, Drury A, Mongkolsapaya J, Moley KH, Mysorekar IU, Screaton GR, Diamond MS. Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection. Nature Immunology. 18(11):1261-1269 (2017).
5. Sapparapu G, Fernandez E, Kose N, Cao B, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, and Crowe JE Jr. Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature.540, 443-447 (2016).
6. Jagger BW, Miner JJ, Cao B,Arora N, Smith AM, Kovacs A, Mysorekar IU, Coyne CB, Diamond MS. Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero. Cell Host & Microbe. 13;22(3):366-376 (2017).
主持项目：
1. 国家重点研发计划“母胎界面分子事件与病理妊娠”课题“胚外组织发育与子痫前期”（2018YFC**）, 427万，在研，主持。
2. 国家自然科学基金：自噬基因Atg16L1再早产中的作用及机制研究（**）, 58 万，在研，主持。
3. FIRM Grant：自噬溶酶体通路调控蜕膜胎盘功能稳态的机制研究（FIRMA200503）, 82 万，在研，主持。
4. 启动经费(含国家及学校部分)，400万，在研，主持

所有论文列表：
1. Pan X, Chen J, Zhou L, Ou X, He F, Liu Y, Zheng S, Wang H, Cao B, Wang Z, Liu H, Liu G, Huang Z, Shen G, Liu S and Chen D. Efficacy and safety of continuous antiviral therapy from preconception to prevent perinatal transmission of hepatitis B virus. Sci Rep. 2020;10:13631.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC**/)
2. Cao B, Sheth M, Mysorekar IU. To Zika and destroy: an antimalarial drug protects fetuses from Zika infection.Future Microbiology.3:137-139(2018).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
3.Cao B, Parnell LA, Diamond MS, Mysorekar I.U. Inhibition of autophagy limits verticaltransmission of Zika virusin pregnant mice. J Exp Med.7;214(8):2303-2313 (2017).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
4. Fernandez E, Dejnirattisai W, Cao B,Scheaffer SM, Supasa P, Wongwiwat W, Esakky P, Drury A, Mongkolsapaya J, Moley KH, Mysorekar IU, Screaton GR, Diamond MS. Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection. Nature Immunology. 18(11):1261-1269 (2017).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
5. Richner MJ, Jagger RB, Shan C, Fontes CR, Dowd KA, Cao B, Himansu S, Salazar V, Caine EA, NunesBT, MedeirosDB, Muruato AE, Foreman BM, Luo H, Wang T, Barrett AD, Weaver SC, VasconcelosPF, Rossi SL, Ciaramella G, Mysorekar IU, Pierson TC, Shi P, Diamond MS. Modified mRNA and live-attenuated vaccines protect against Zika virus transmission in pregnancy. Cell.170:273-283 e212 (2017).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
6. Jagger BW, Miner JJ, Cao B,Arora N, Smith AM, Kovacs A, Mysorekar IU, Coyne CB, Diamond MS. Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero. Cell Host & Microbe. 13;22(3):366-376 (2017).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
7. Cao B*, Camden AJ*, Parnell LA, Mysorekar IU. Autophagy regulation of physiological and pathological processes in the female reproductive tract. Am J Reprod Immunol. May;77(5)(2017).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
8. Hastings AK*, Yockey LJ*, Jagger BW*, Hwang J, Uraki R, Gaitsch HF, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. TAM receptors are not required for Zika Virus infection in mice. Cell Reports.19, 558-568 (2017).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
9. Cao B, Diamond MS, Mysorekar IU. Maternal-fetal transmission of Zika virus: Routes and Signals for Infection. Journal of Interferon and Cytokine Research.37:287-294 (2017).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
10. Parnell LA, Briggs C, Cao B, Delannoy-Bruno O, Schrieffer AE, Mysorekar I. Microbial communities in placentas from term normal pregnancy exhibit spatially variable profiles. Scientific Reports. 11;7(1):11200 (2017).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
11. Miner JJ*, Cao B*,Govero J,Smith AM,Fernandez E,Cabrera OH,Garber C,Noll M,Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell. 165, 1081-91 (2016). (*Co-first author).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
12.Cao B, Macones C, Mysorekar IU. ATG16L1 governs the placental syncytial barrier to infection and risk of premature birth in pregnant mice and women. JCI Insight. e86654 (2016).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
13. Sapparapu G, Fernandez E, Kose N, Cao B, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, and Crowe JE Jr. Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature.540, 443-447 (2016).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
14. Stout MJ, Cao B, Landeau M, French J, Macones GA, Mysorekar IU. Increased human leukocyte antigen-G expression at the maternal-fetal interface is associated with preterm birth. J Matern Fetal Neonatal Med. 28(4):454-9 (2015).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
15.Cao B, Mysorekar IU. Intracellular bacteria in placental basal plate localize to extravillous trophoblasts. Placenta. 35(2):139-42 (2014).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
16. Li S, Wang Y, Cao B,Wu Y, Ji L, Li YX, Liu M, Zhao Y, Qiao J, Wang H, Wang H, Han C and Wang YL. Maturation of GDF15 in human placental trophoblast cells depends on the interaction with matrix metalloproteinase-26 (MMP-26). J Clin Endocrinol Metab. 99 (11): E2277-E2287 (2014).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
17. Mysorekar IU and Cao B. Microbiome in parturition and preterm birth. Semin Reprod Med.32(1):50-5 (2014).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
18.Cao B, Stout MJ, Lee I and Mysorekar IU. Placental Microbiome and Its Role in Preterm Birth. NeoReviews.15(12):e537-e45 (2014).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
19. Yang Y, Wang Y, Zeng X, Ma XJ, Zhao Y, Qiao J, Cao B, Li YX, Ji L and Wang YL. Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17. J Clin Endocrinol Metab. 97(8):E1390-401(2012).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
20. Yu L, Li D, Liao QP, Yang HX, Cao B, Fu G, Ye G, Bai Y, Wang H, Cui N, Liu M, Li YX, Li J, Peng C and Wang YL. High levels of activin A detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting nodal signaling. J Clin Endocrinol Metab. 97(8):E1370-9 (2012).
(https://www.ncbi.nlm.nih.gov/pubmed/**)
21. Liu J*, Cao B*, Li YX, Wu XQ and Wang YL. GnRH I and II up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts. Reprod Biol Endocrinol.8:5 (2010). (*Co first author)
(https://www.ncbi.nlm.nih.gov/pubmed/**)
22. Liu J, Li D, Cao B,Li YX, Herva R, Piao YS, Wang YL. Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation. J Histochem Cytochem. 55(7):701-8 (2007).
(https://www.ncbi.nlm.nih.gov/pubmed/**)