李鸿珠 教授/博导
学科（方向）：病理生理学
所在系部：基础医学部
邮箱：hongzhuli61@163.com


研究领域：

心血管疾病是危害人类健康的最主要杀手，特别是缺血性心脏病。糖尿病不可怕，糖尿病的并发症是患者致死的主要原因。糖尿病诱发的心血管疾病致死率极高，其都与心肌细胞和血管细胞的缺血、缺氧密切相关。
众所周知，人口老龄化是当今世界一个突出性的社会问题，我国人口老龄化发展速度尤其之快。减缓衰老，特别是减缓心肌细胞衰老，提高老年人的生活质量，已经成为全社会研究的热点。
继 一氧化氮（NO）和 一氧化碳（CO）之后，硫化氢（H₂S）是新发现的一种内源性气体信号分子。H₂S 具有广泛的生物学效应，例如，抑制细胞增殖、炎症反应，调控凋亡、氧化应激、线粒体通透转换孔（mPTP）、离子通道及细胞信号转导通路等。
实验室目前主要的研究方向如下：
（一）H₂S在糖尿病血管平滑肌细胞增殖中的作用及机制；
（二）H₂S在心肌细胞衰老中的作用及机制。
学习经历：
2005/08-2008/07，哈尔滨医科大学，病理学与病理生理学专业，博士
2002/08-2005/06，哈尔滨医科大学，病理学与病理生理学专业，硕士
1997/08-2002/07，牡丹江医学院，临床医学专业，学士
工作经历：
2020/11--至今 厦门大学医学院，病理生理学专业，教授、硕士和博士研究生导师
2015/09--2020/10 哈尔滨医科大学，病理生理学教研室，教授、硕士和博士研究生导师
2010/09--2015/09 哈尔滨医科大学，病理生理学教研室，副教授、硕士研究生导师
2009/10--2011/10 Department of Biology，Lakehead University of Canada，博士后
2008/08--2011/05 哈尔滨医科大学，药学博士后流动站，博士后
2008/09--2010/09 哈尔滨医科大学，病理生理学教研室，讲师
主持课题：
1. 国家自然科学基金项目（面上项目，NO. **，2018.01-2021.12）；
2. 国家自然科学基金项目（面上项目，NO. **，2013.01-2016.12）；
3. 国家自然科学基金项目（青年基金，NO. **，2011.1-2013.12）；
4. 黑龙江省自然科学基金项目（NO. LH2020H012，2020.07-2023.07）；
5. 黑龙江省归国留学基金项目（NO. LC201430，2014.07-2017.07）；
6. 黑龙江省教育厅科研课题（NO. **，2013.01-2015.12）；
7. 黑龙江省博士后科研启动基金（NO. LBH-Q11054，2012.01-2014.12）；
8. 黑龙江省卫生厅科研课题（NO. 2009-214，2010.01-2011.12）；
9. 哈尔滨医科大学研究生创新基金项目（NO. HCXB**，2007.01-2009.12）。
荣誉奖励：
1. 2019年10月，荣获黑龙江省政府科学技术二等奖；
2. 2019年2 月，荣获黑龙江省高校科学技术二等奖；
3. 2009年3月，荣获黑龙江省高校科学技术三等奖；
4. 2008年2月，荣获黑龙江省科高校科学技术一等奖。
学术兼职：
1. 中国病理生理学会动脉粥样硬化专业委员会、国际动脉粥样硬化学会中国分会、胆固醇逆向转运(RCT)专家组委员
2. 国家自然科学基金一审专家
3. 浙江省自然科学基金评审专家
4. 江西省自然科学基金评审专家
5. 国际心血管学会（ISHR）会员
6. 国际病理生理学会（ISP）会员
7. ISHR 中国分会会员
8. 海峡两岸心血管学会会员
9. 中国病理生理学会会员
10. 《中华临床医师》杂志特约编辑
代表性成果：
1. Junting Chen, Jun Gao, Weiming Sun, Lina Li, Yuehong Wang, Shuzhi Bai, Xiaoxue Li, Rui Wang, Lingyun Wu, Hongzhu Li (通讯作者), Changqing Xu. Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts.Int J Cardiol. 2016;220:681-692.
2. Can Wei, Jun Gao, Meixiu Li, Hong Li, YuehongWang, Hongzhu Li (通讯作者) , Changqing Xu. Dopamine D2 receptors contribute to cardioprotection of ischemic post-conditioning via activating autophagy in isolated rat hearts. Int J Cardiol. 2016;203:837-839.
3. Yuan zhou Zhang, Jun Gao, Weiming Sun, Xin Wen, Yuxin Xi, Yuehong Wang, Can Wei, Changqing Xu, Hongzhu Li (通讯作者). H2S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling. Aging-US.2019;11:1745-1758.
4. Hongzhu Li (第一作者), Sarathi Mani, Wei Cao, Guangdong Yang, Christopher Lai, Lingyun Wu, Rui Wang. Interaction of hydrogen sulfide and estrogen on the proliferation of vascular smooth muscle cells. Plos one. 2012;7(8):e41614.
5. Hongzhu Li (第一作者),Sarathi Mani,Lingyun Wu,Ming Fu,Shuang Tian,Changqing Xu, Rui Wang. TheinteractionofestrogenandCSE/H2Spathwayinthedevelopmentofatherosclerosis. Am J Physiol Heart Circ Physiol.2017;312:H406-H414.
6. Hongzhu Li (第一作者及通讯作者)，Can Wei, Jun Gao, Shuzhi Bai, Hongxia Li, Yajun Zhao, Hong Li, Liping Han, Ye Tian, Guangdong Yang, Rui Wang, Lingyun Wu, Changqing Xu. Mediation of dopamine D2 receptors activation in post-conditioning-attenuated cardiomyocyte apoptosis. Exp Cell Res. 2014;323(3):118-130.
7. Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu,Hongzhu Li (通讯作者),Changqing Xu. Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes. Cell Biosci. 2017;7:67.
8. Lina Li, Meixiu Li, Weiming Sun, Yuehong Wang, Shuzhi Bai, Hongxia Li, Bo Wu, Guangdong Yang, Rui Wang, Lingyun Wu, Hongzhu Li (通讯作者), Changqing Xu. Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes. Cell Biosci. 2016;6:26.
9. Hongzhu Li (第一作者及通讯作者), Chao Zhang, Weiming Sun, Lina Li, Bo Wu, Shuzhi Bai, Hong Li, Xin Zhong, Rui Wang, Lingyun Wu, Changqing Xu. Exogenous hydrogen sulfide restores cardioprotection of ischemic post-conditioning via inhibition of mPTP opening in the aging cardiomyocytes.Cell Biosci. 2015;5:43.
10. Hongzhu Li (第一作者及通讯作者), Yuehong Wang, Can Wei, Shuzhi Bai, Yajun Zhao, Hongxia Li, Bo Wu, Rui Wang, Lingyun Wu, Changqing Xu. Mediation of exogenous hydrogen sulfide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K/Akt/GSK-3β athway in isolated aging rat hearts. Cell Biosci. 2015;5:11.
11. Jun Gao,Chao Zhang,Feng Gao,Hongzhu Li (通讯作者). TheeffectandmechanismofdopamineD1receptorsontheproliferationofosteosarcomacells. Mol Cell Biochem.2017;430(1-2):31-36.
12. Jun Gao, Jin Guo, Hongxia Li, Shuzhi Bai, Hong Li, Bo Wu, Lina Wang, Yuhui Xi, Ye Tian, Guangdong Yang, Rui Wang, Lingyun Wu, Changqing Xu, Hongzhu Li(通讯作者). Involvement of dopamine D2 receptors activation in ischemic post-conditioning-induced cardioprotection through promoting PKC-ε particulate translocation in isolated rat hearts. Mol Cell Biochem. 2013;379(1-2):267-276.
13. Hong-zhu Li (第一作者), Li-ping Han, Chun-ming Jiang, Hong Li, Ya-jun Zhao,Jun Gao, Yan Lin, Shu-xia Ma, Ye Tian, Bao-feng Yang, Chang-qing Xu. Effect of Dopamine Receptor-1 on Apoptosis of Cultured Neonatal Rat Cardiomyocytes in Simulated Ischemia/Reperfusion. Basic & Clinical Pharmacology & Toxicology. 2008;102(3):329-336.
14. Hong-zhu Li (第一作者), Jin Guo, Jun Gao, Li-ping Han, Chun-ming Jiang, Hong-xia Li, Shu-zhi Bai, Wei-hua Zhang, Guang-wei Li, Li-na Wang, Hong Li, Ya-jun Zhao, Yan Lin, Ye Tian, Guang-dong Yang, Rui Wang, Ling-yun Wu, Bao-feng Yang, Chang-qing Xu. Role of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes.J Biomed Sci. 2011;18:18.
15. Can Wei, Yan Zhao, Lina Wang, Xue Peng, Hong Li, Yajun Zhao, Yuqin He, Hongjiang Shao, Xin Zhong, Hongzhu Li (通讯作者). H2S restores the cardioprotection from ischemic post-conditioning in isolated aged rat hearts.Cell Biol Int. 2015;39: 1173-1176.
16. Jin Guo, Hong-zhu Li (并列第一作者), Lu-chuan Wang, Wei-hua Zhang, Guang-wei Li, Wen-jing Xing, Rui Wang, Chang-qing Xu. Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats. Mol Cell Biochem. 2012;366(1-2):345–354.
17. Jin Guo, Hong-zhu Li (并列第一作者), Weihua Zhang, Luchuan Wang,Lina Wang, Li Zhang, Guangwei Li, Hongxia Li, Baofeng Yang, Lingyun Wu, Rui Wang, Changqing Xu. Increased expression of calcium-sensing receptors induced by ox-LDL amplifies cardiomyocyte apoptosis during simulated ischemia/reperfusion. Clin Exp Pharmacol Physiol. 2010;37(3):e128–e135.
所有论文列表：
1. Junting Chen, Jun Gao, Weiming Sun, Lina Li, Yuehong Wang, Shuzhi Bai, Xiaoxue Li, Rui Wang, Lingyun Wu, Hongzhu Li (通讯作者), Changqing Xu. Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts.Int J Cardiol. 2016;220:681-692.
2. Can Wei, Jun Gao, Meixiu Li, Hong Li, YuehongWang, Hongzhu Li (通讯作者) , Changqing Xu. Dopamine D2 receptors contribute to cardioprotection of ischemic post-conditioning via activating autophagy in isolated rat hearts. Int J Cardiol. 2016;203:837-839.
3. Yuan zhou Zhang, Jun Gao, Weiming Sun, Xin Wen, Yuxin Xi, Yuehong Wang, Can Wei, Changqing Xu, Hongzhu Li (通讯作者). H2S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling. Aging-US.2019;11:1745-1758.
4. Hongzhu Li (第一作者), Sarathi Mani, Wei Cao, Guangdong Yang, Christopher Lai, Lingyun Wu, Rui Wang. Interaction of hydrogen sulfide and estrogen on the proliferation of vascular smooth muscle cells. Plos one. 2012;7(8):e41614.
5. Hongzhu Li (第一作者),Sarathi Mani,Lingyun Wu,Ming Fu,Shuang Tian,Changqing Xu, Rui Wang. TheinteractionofestrogenandCSE/H2Spathwayinthedevelopmentofatherosclerosis. Am J Physiol Heart Circ Physiol.2017;312:H406-H414.
6. Hongzhu Li (第一作者及通讯作者)，Can Wei, Jun Gao, Shuzhi Bai, Hongxia Li, Yajun Zhao, Hong Li, Liping Han, Ye Tian, Guangdong Yang, Rui Wang, Lingyun Wu, Changqing Xu. Mediation of dopamine D2 receptors activation in post-conditioning-attenuated cardiomyocyte apoptosis. Exp Cell Res. 2014;323(3):118-130.
7. Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu,Hongzhu Li (通讯作者),Changqing Xu. Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes. Cell Biosci. 2017;7:67.
8. Lina Li, Meixiu Li, Weiming Sun, Yuehong Wang, Shuzhi Bai, Hongxia Li, Bo Wu, Guangdong Yang, Rui Wang, Lingyun Wu, Hongzhu Li (通讯作者), Changqing Xu. Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes. Cell Biosci. 2016;6:26.
9. Hongzhu Li (第一作者及通讯作者), Chao Zhang, Weiming Sun, Lina Li, Bo Wu, Shuzhi Bai, Hong Li, Xin Zhong, Rui Wang, Lingyun Wu, Changqing Xu. Exogenous hydrogen sulfide restores cardioprotection of ischemic post-conditioning via inhibition of mPTP opening in the aging cardiomyocytes.Cell Biosci. 2015;5:43.
10. Hongzhu Li (第一作者及通讯作者), Yuehong Wang, Can Wei, Shuzhi Bai, Yajun Zhao, Hongxia Li, Bo Wu, Rui Wang, Lingyun Wu, Changqing Xu. Mediation of exogenous hydrogen sulfide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K/Akt/GSK-3β athway in isolated aging rat hearts. Cell Biosci. 2015;5:11.
11. Jun Gao,Chao Zhang,Feng Gao,Hongzhu Li (通讯作者). TheeffectandmechanismofdopamineD1receptorsontheproliferationofosteosarcomacells. Mol Cell Biochem.2017;430(1-2):31-36.
12. Jun Gao, Jin Guo, Hongxia Li, Shuzhi Bai, Hong Li, Bo Wu, Lina Wang, Yuhui Xi, Ye Tian, Guangdong Yang, Rui Wang, Lingyun Wu, Changqing Xu, Hongzhu Li(通讯作者). Involvement of dopamine D2 receptors activation in ischemic post-conditioning-induced cardioprotection through promoting PKC-ε particulate translocation in isolated rat hearts. Mol Cell Biochem. 2013;379(1-2):267-276.
13. Hong-zhu Li (第一作者), Li-ping Han, Chun-ming Jiang, Hong Li, Ya-jun Zhao,Jun Gao, Yan Lin, Shu-xia Ma, Ye Tian, Bao-feng Yang, Chang-qing Xu. Effect of Dopamine Receptor-1 on Apoptosis of Cultured Neonatal Rat Cardiomyocytes in Simulated Ischemia/Reperfusion. Basic & Clinical Pharmacology & Toxicology. 2008;102(3):329-336.
14. Hong-zhu Li (第一作者), Jin Guo, Jun Gao, Li-ping Han, Chun-ming Jiang, Hong-xia Li, Shu-zhi Bai, Wei-hua Zhang, Guang-wei Li, Li-na Wang, Hong Li, Ya-jun Zhao, Yan Lin, Ye Tian, Guang-dong Yang, Rui Wang, Ling-yun Wu, Bao-feng Yang, Chang-qing Xu. Role of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes.J Biomed Sci. 2011;18:18.
15. Can Wei, Yan Zhao, Lina Wang, Xue Peng, Hong Li, Yajun Zhao, Yuqin He, Hongjiang Shao, Xin Zhong, Hongzhu Li (通讯作者). H2S restores the cardioprotection from ischemic post-conditioning in isolated aged rat hearts.Cell Biol Int. 2015;39: 1173-1176.
16. Jin Guo, Hong-zhu Li (并列第一作者), Lu-chuan Wang, Wei-hua Zhang, Guang-wei Li, Wen-jing Xing, Rui Wang, Chang-qing Xu. Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats. Mol Cell Biochem. 2012;366(1-2):345–354.
17. Jin Guo, Hong-zhu Li (并列第一作者), Weihua Zhang, Luchuan Wang,Lina Wang, Li Zhang, Guangwei Li, Hongxia Li, Baofeng Yang, Lingyun Wu, Rui Wang, Changqing Xu. Increased expression of calcium-sensing receptors induced by ox-LDL amplifies cardiomyocyte apoptosis during simulated ischemia/reperfusion. Clin Exp Pharmacol Physiol. 2010;37(3):e128–e135.
18. Chen JT, Shi S, Cai X, Li HZ, Wang LN, Li H, Xu CQ. DR1 activation reduces the proliferation of vascular smooth muscle cells by JNK/c-Jun dependent increasing of Prx3.Mol Cell Biochem. 2018;440:157-165.
19. Wang YH, Gao P, Wei C, Li HZ, Zhang L, Zhao YJ, Wu B, Tian Y, Zhang WH, Wu LY, Wang R, Xu CQ. Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.Cell Death Dis. 2017;:e2799.
20. Wei C, Li HZ, Wang YH, Peng X, Shao HJ, Li HX, Bai SZ, Lu XX, Wu LY, Wang R, Xu CQ. Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2- and PI3K/AKT-associated pathways.Int J Mol Med. 2016;37:39-46.
21. Wei C, Li HZ, Wang YH, Peng X, Shao HJ, Li HX, Bai SZ, Xu CQ. Exogenous spermine inhibits hypoxia/ischemia-induced myocardial apoptosis via regulation of mitochondrial permeability transition pore and associated pathways.Exp Biol Med (Maywood). 2016;241:1505-1515.
22. Wei C, Wang YH, Li MX, Li HZ, Lu X, Shao HJ, Xu CQ. Spermine inhibits Endoplasmic Reticulum Stress-induced Apoptosis: a New Strategy to Prevent Cardiomyocyte Apoptosis.Cell Physiol Biochem. 2016;38:531-544.
23. Wang YW, Wang X, Liang X, Wu J, Dong SY, Li HZ, Jin M, Sun D, Zhang WH, Zhong X. Inhibition of hydrogen sulfide on the proliferation of vascular smooth muscle cells involved in the modulation of calcium sensing receptor in high homocysteine.Exp Cell Res. 2016;347:184-191.
24. He YQ, Yang JX, Li HZ, Shao HJ, Wei C, Wang YH, Li MX, Xu CQ. Exogenous spermine ameliorates high glucose-induced cardiomyocytic apoptosis via decreasing reactive oxygen species accumulation through inhibiting p38/JNK and JAK2 pathways.Int J Clin Exp Pathol. 2015;8:15537-15549.
25. Wu B, Teng HJ, Zhang L, Li HZ, Li J, Wang LN, Li H. Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia.Oxid Med Cell Longev. 2015;2015:758678.
26. Wang WW, Zhang H, Xue G, Zhang L, Zhang WH, Wang LN, Lu FH, Li HZ, Bai SZ, Lin Y, Lou Y, Xu CQ, Zhao YJ. Exercise training preserves ischemic preconditioning in aged rat hearts by restoring the myocardial polyamine pool.Oxid Med Cell Longev. 3014;2014:457429.
27. Zhao KX, Li HZ, Li S, Guangdong Yang. Regulation of cystathionine gamma-lyase/H2S system and its pathological implication. Frontier in Bioscience. 2014;19:1355-1369.
28. Mani S, Li HZ, Untereiner A, Wu L, Yang G, Richard C, Jeffrey G, Meng Q, Wang R. Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation. 2013;127:2523-2534.
29. Yang G, Li HZ, Tang G, Wu L, Zhao K, Cao QH, Xu CQ, Wang R. Increased neointimal formation in cystathionine gamma-lyase deficient mice: Role of hydrogen sulfide in α5β1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells. J Mol Cell Cardiol.2012;52:677-688.
30. Fu M, Zhang WH, Wu LY, Yang GD, Li HZ, Wang R. Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production. Proc Natl Acad Sci U S A.2012;109(8):2943-2948.
31. Xi YH, Li HZ, Zhang WH, Wang LN, Xu CQ. The functional expression of calcium-sensing receptor in the differentiated THP-1 cells. Mol Cell Biochem. 2010;342:233-240.
32. Wu B, Teng HJ, Zhang L, Li H, Li J, Wang LN, Li HZ. Interaction of Hydrogen Sulfide with Oxygen Sensing under Hypoxia.Oxid Med Cell Longev. 2015;2015:758678.
33. Peng X, Li HX, Shao HJ, Li GW, Sun J, Xi YH, Li HZ, Wang XY, Wang LN, Bai SZ, Zhang WH, Zhang L, Yang GD, Wu LY, Wang R, Xu CQ. Involvement of calcium-sensing receptors in hypoxia-induced vascular remodeling and pulmonary hypertension by promoting phenotypic modulation of small pulmonary arteries.Mol Cell Biochem. 2014;396(1-2): 87-98.
34. Han LP, Xu CQ, Jiang CM, Li HZ, Weihua Zhang,Yajun Zhao, Li Zhang, Yanqiao Zhang, Weiming Zhao, Baofeng Yang. Effects of polyamines on apoptosis induced by simulated ischemia/reperfusion injury in cultured neonatal rat cardiomyocytes. Cell Biology International. 2007;31(11):1345-1352.
35. Peng X, Li HX, Shao HJ, Li GW, Sun J, Xi YH, Li HZ, Wang XY, Wang LN, Bai SZ, Zhang WH, Zhang L, Yang GD, Wu LY, Wang R, Xu CQ. Involvement of calcium-sensing receptors in hypoxia-induced vascular remodeling and pulmonary hypertension by promoting phenotypic modulation of small pulmonary arteries.Mol Cell Biochem. 2014;396(1-2):87-98.
36. Wang WW, Zhang H, Xue G, Zhang L, Zhang WH, Wang LN, Lu FH, Li HZ, Bai SZ, Lin Y, Lou Y, Xu CQ, Zhao YJ. Exercise training preserves ischemic preconditioning in aged rat hearts by restoring the myocardial polyamine pool.Oxid Med Cell Longev. 2014;2014:457429.
37. Bai SZ, Sun J, Wu H, Zhang N, Li HX, Li GW, Li HZ, He W, Zhang WH, Zhao YJ, Wang LN, Tian Y, Yang BF, Yang GD, Wu LY, Wang R, Xu CQ. Decrease in calcium-sensing receptor in the progress of diabetic cardiomyopathy. Diabetes Res Clin Pract.2012;95:378-385.
38. Li GW, Xing WJ, Bai SZ, Hao JH, Guo J, Li HZ, Li HX, Zhang WH, Yang BF, Wu LY, Wang R, Yang GD, Xu CQ. The calcium-sensing receptor mediates hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells through MEK1/ERK1,2 and PI3K pathways. Basic Clin Pharmacol Toxicol.2011;108:185-193.
39. Li GW, Wang QS, Hao JH, Xing WJ, Guo J, Li HZ, Bai SZ, Li HX, Zhang WH, Yang BF, Yang GD, Wu LY, Wang R, Xu CQ. The functional expression of extracellular calcium-sensing receptor in rat pulmonary artery smooth muscle cells. J Biomed Sci.2011;18:16.
40. Li HX, Kong FJ, Bai SZ, He W, Xing WJ, Xi YH, Li GW, Guo J, Li HZ, Wu LY, Wang R, Yang GD, Tian Y, Xu CQ. Involvement of calcium-sensing receptor in oxLDL-induced MMP-2 production in vascular smooth muscle cells via PI3K/Akt pathway. Mol Cell Biochem.2012;362:115-122.
41. Gan RT, Hu GG, Zhao YJ, Li HL, Jin ZF, Ren H, Dong SY, Zhong X, Li HZ, Yang BF, Xu CQ, Lu FH, Zhang WH. Post-conditioning protecting rat cardiomyocytes from apoptosis via attenuating calcium-sensing receptor-induced endo(sarco)plasmic reticulum stress. Mol Cell Biochem.2012;361:123-134.
42. Zheng HS, Liu J, Liu C, Lu FG, Zhao YJ, Jin ZF, Ren H, Leng XN, Jia J, Hu GG, Dong SY, Zhong X, Li HZ, Yang BF, Xu CQ, Zhang WH. Calcium-sensing receptor activating phosphorylation of PKCd translocation on mitochondria to induce cardiomyocyte apoptosis during ischemia/reperfusion. Mol Cell Biochem. 2011;358:335–343.
43. Han LP, Xu CQ, Guo YM, Li HZ, Jiang CM, Zhao YJ. Polyamine metabolism in rat myocardial ischemia-reperfusion injury. Int J Cardiol. 2009;132:142-144.
44. Zhao YJ, Zhang WH, Xu CQ, Li HZ, Wang LN, Li H, Sun YH, Lin Y, Han LP, Zhang L, Tian Y, Wang R, Yang BF, Li WM. Involvement of the ornithine decarboxylase/polyamine system in precondition-induced cardioprotection through an interaction with PKC in rat hearts. Mol Cell Biochem. 2009;332:135-144.
45. Jiang CM，Xu CQ, Han LP，Li HZ. Calcium-sensing receptor induces apoptosis of cultured neonatal rat ventricular cardiomyocytes in simulated ischemia/reperfusion. Cell Biology International. 2008;32(7):792-800.
46. Lin Y, Wang LN, Xi YH, Li HZ, Xiao FG, Zhao YJ, Tian Y, Yang BF, Xu CQ. L-arginine inhibits isoproterenol-induced cardiac hypertrophy through nitric oxide and polyamines pathways. Basic Clin Pharmacol Toxicol.2008;103:124-130.
47. Xing WJ, Li GW, Xi YH, Guo J, Li HZ,Li HX, Xu CQ. The functional expression of calcium-sensing receptors in BRL cells and related signal transduction pathway responsible for intracellular calcium elevation. Mol Cell Biochem. 2010;343:13-19.
48. Li H, Shi S, Sun YH, Zhao YJ, Li QF, Li HZ, Wang R, Xu CQ. Dopamine D2 receptor stimulation inhibits angiotensin II-induced hypertrophy in cultured neonatal rat ventricular myocytes. Clin Exp Pharmacol Physiol. 2009;36:312-318.
49. Lin Y, Liu JC, Zhang XJ, Li GW, Wang LN, Xi YH, Li HZ, Zhao YJ, Xu CQ. Downregulation of the ornithine decarboxylase/polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the NO/cGMP-dependent protein kinase type-I pathway. Cell Physiol Biochem. 2010;25:441-448.
50. Wang LN, Wang C, Lin Y, Xi YH, Zhang WH, Zhao YJ, Li HZ, Tian Y, Lv YJ, Yang BF, Xu CQ. Involvement of calcium-sensing receptor in cardiac hypertrophy-induced by angiotensin II through calcineurin pathway in cultured neonatal rat cardiomyocytes. Biochem Biophys Res Commun. 2008;369:584-589.