张鸿声 副教授
学科（方向）：神经生物学
所在系部：神经科学研究所
邮 箱：hszhang@xmu.edu.cn







研究领域：
星形胶质细胞是哺乳动物神经系统中最为丰富的细胞，它们对神经元的发育、突触的形成和功能的维持具有重要的作用。本课题组致力于神经发育和神经退行性疾病的分子机制研究，主要包括精神分裂症和阿尔茨海默病等。利用基因修饰、分子生化、细胞生物学、电生理学、动物行为学和多组学分析等手段，以临床样本、细胞模型和小鼠模型为研究对象，深入研究大脑发育与神经系统疾病中星形胶质细胞的作用及分子机制。旨在通过全面了解星形胶质细胞在发育和疾病中的作用进而通过靶向星形胶质细胞来治疗或改善疾病。
学习经历：
2002/09-2006/07 福建农林大学生命科学院 生物科学专业 理学学士；
2006/09-2009/07 福建农林大学生命科学院 生物化学与分子生物学专业 理学硕士；
2007/07-2008/12 军事医学科学院生物工程研究所 联合培养；
2009/09-2014/07 中国科学院遗传与发育生物学研究所 细胞生物学 理学博士；
工作经历：
2014/08-2014/12 中国科学院遗传与发育生物学研究所 博士后；
2015/01-2017/10 美国奥古斯塔大学 神经科学与再生医学系 博士后；
2017/11-2019/10 美国凯斯西储大学 神经科学系 博士后；
2019/11-2020/2 美国凯斯西储大学 神经科学系 Research Scientist；
2020/11-至今 厦门大学医学院 副教授
代表性成果：
1.Hongsheng Zhang^#, Eunchai Kang^#, Yaqing Wang^#, ChaojuanYang, Hui Yu, Qin Wang, Zheyu Chen, Chen Zhang, Kimberly M Christian, Hongjun Song, Guo-li Ming*, Zhiheng Xu*. Brain-specific Crmp2 deletion leads to neuronal development deficits and behaviouralimpairments in mice. Nat Commun. 2016 Jun 1;7. (^#, equal contributing; *, corresponding).
2.Hongsheng Zhang, Anupama Sathyamurthy, Fang Liu, Lei Li, Lei Zhang, Zhaoqi Dong, Wanpeng Cui, Xiangdong Sun, Kai Zhao, Hongsheng Wang, Hsin-Yi Henry Ho, Wen-Cheng Xiong, Lin Mei*.Agrin-Lrp4-Ror2 signaling regulatesadult hippocampal neurogenesis in mice. Elife. 2019 Jul 3; 8.(*, corresponding).
3.Hongsheng Zhang, Wenbing Chen, Zhibing Tan, Lei Zhang, Zhaoqi Dong, Wanpeng Cui, Kai Zhao, Hongsheng Wang, Hongyang Jing, Rangjuan Cao, Chae Kim, Jiri G. Safar, Wen-Cheng Xiong, Lin Mei*.A role of low-density lipoprotein receptor-related protein 4 (LRP4) inastrocytic Aβ clearance.J Neurosci. 2020 July 8;40(28)5347-5361.(*, corresponding).

所有论文列表
1.Hongsheng Zhang^#, Eunchai Kang^#, Yaqing Wang^#, ChaojuanYang, Hui Yu, Qin Wang, Zheyu Chen, Chen Zhang, Kimberly M Christian, Hongjun Song, Guo-li Ming*, Zhiheng Xu*. Brain-specific Crmp2 deletion leads to neuronal development deficits and behaviouralimpairments in mice. Nat Commun. 2016 Jun 1;7. (^#, equal contributing; *, corresponding).
2.Yaqing Wang^#, Liang Liu^#, Hongsheng Zhang, Junwan Fan, Feng Zhang, Mei Yu, Lei Shi, Lin Yang, Sin Man Lam, Huimin Wang, Xiaowei Chen, Yingchun Wang, Fei Gao, GuanghouShui, Zhiheng Xu. Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.Cell Res. 2016 Jul; 26(7): 787–804. (^#, equal contributing; *, corresponding).
3.Hui-Feng Jiao^#, Xiang-Dong Sun^#, Ryan Bates^#, Lei Xiong, Lei Zhang, Fang Liu, Lei Li, Hong-Sheng Zhang, Shun-Qi Wang, Ming-Tao Xiong, Mihir Patel, Alexis M Stranahan, Wen-Cheng Xiong, Bao-Ming Li, Lin Mei*.Transmembrane protein 108 is requiredfor glutamatergic transmission in dentategyrus.Proc Natl Acad Sci USA.2017 Jan 31; 114(5): 1177-1182. (^#, equal contributing; *, corresponding).
4. Junwan Fan^#, Yaqing Wang^#*, Liang Liu, Hongsheng Zhang, Feng Zhang, Lei Shi, Mei Yu, Fei Gao, Zhiheng Xu*.cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.J Cell Biol.2017 Dec 4;216(12): 4153-4164.(^#, equal contributing;*, corresponding).
5.Joanna Ruth Appel, Shiyang Ye, Fulei Tang, Dong Sun, Hongsheng Zhang, Lin Mei, Wen-Cheng Xiong*.Increased microglial activity, impaired adult hippocampal neurogenesis, and depressive-like behavior in microglial VPS35-depleted mice.J Neurosci. 2018 Jun 27; 38 (26): 5949-5968.(*, corresponding).
6.Feng Zhang^#, Yaqing Wang^#, Tao Wang, Li Yao, Sin Man Lam, Xiahe Huang, Junwan Fan, Qin Wang, Liang Liu, Yisheng Jiang, Hongsheng Zhang, Lei Shi, Mei Yu, GuanghouShui, Yingchun Wang, Fei Gao, Xiaohui Zhang, Zhiheng Xu*.cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development.Proc Natl Acad Sci USA. 2018 Ocr 2; 115(40): E9449-E9458.(^#, equal contributing;*, corresponding).
7.Kai Zhao^#, Chengyong Shen^#, Lei Li^#, Haitao Wu, Guanglin Xing, Zhaoqi Dong, Hongyang Jing, Wenbing Chen, Hongsheng Zhang, Zhibing Tan, Jinxiu Pan, Lei Xiong, Hongsheng Wang, Wanpeng Cui, Xiang-Dong Sun, Shihua Li, Xinping Huang, Wen-Cheng Xiong, Lin Mei.Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4. J Neurosci. 2018 Oct 10; 38(41): 8860-8873.(^#, equal contributing;*, corresponding).
8.Hongsheng Wang^#, Fang Liu^#, Wenbing Chen^#, Xiangdong Sun, Wanpeng Cui, Zhaoqi Dong, Kai Zhao, Hongsheng Zhang, Haiwen Li, Guanglin Xing, Erkang Fei, Bing-Xing Pan, Bao-Ming Li, Wen-Cheng Xiong, Lin Mei.Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice.Proc Natl Acad Sci USA.2018 Dec 18; 115(51): 13105-13110. (^#, equal contributing;*, corresponding).
9.Hongsheng Zhang, Anupama Sathyamurthy, Fang Liu, Lei Li, Lei Zhang, Zhaoqi Dong, Wanpeng Cui, Xiangdong Sun, Kai Zhao, Hongsheng Wang, Hsin-Yi Henry Ho, Wen-Cheng Xiong, Lin Mei*.Agrin-Lrp4-Ror2 signaling regulatesadult hippocampal neurogenesis in mice. Elife. 2019 Jul 3; 8.(*, corresponding).
10.Hongsheng Zhang, Wenbing Chen, Zhibing Tan, Lei Zhang, Zhaoqi Dong, Wanpeng Cui, Kai Zhao, Hongsheng Wang, Hongyang Jing, Rangjuan Cao, Chae Kim, Jiri G. Safar, Wen-Cheng Xiong, Lin Mei*.A role of low-density lipoprotein receptor-related protein 4 (LRP4) inastrocytic Aβ clearance.J Neurosci. 2020 July 8;40(28)5347-5361.(*, corresponding).
11.LeiZhang, Hongyang Jing, Haiwen Li, Wenbing Chen, Bin Luo, Hongsheng Zhang, Zhaoqi Dong, Lei Li, Huabo Su, Wen-cheng Xiong, and Lin Mei*. Neddylation is critical to cortical development by regulating Wnt/β-catenin signaling.Proc Natl Acad Sci USA. 2020 Oct 20; 117 (42), 26448-26459. (*, corresponding).
12. Lingling Yao, Jin-xia Hu, Qiang Li, Daehoon Lee, Xiao Ren, Jun-shi Zhang, Dong Sun, Hong-sheng Zhang, Yong-gang Wang, Lin Mei, and Wen-Cheng Xiong*.Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex.J Clin Invest. Aug 27,2020. In press.(*, corresponding).
All publications:https://scholar.google.com/citations?user=tAPxUncAAAAJ&hl=zh-CN