魏杰 副教授/硕导
学科（方向）：病理生理学/环境表观遗传学
所在系部：基础医学部
办公电话：
邮 箱：jiewei@xmu.edu.cn




研究领域：
环境因素引起机体肥胖、胰岛素抵抗、2型糖尿病等慢性代谢性疾病的表观遗传机制研究。

学习经历：
2000～2005 兰州大学公共卫生学院 医学学士；
2005～2008 兰州大学公共卫生学院 医学硕士；
2008～2011 华中科技大学公共卫生学院 医学博士。
工作经历：
2011.09～2014.03 厦门大学 生命科学学院 博士后；
2014.04～至今厦门大学 医学院 副教授。
代表性成果（* corresponding author; # co-first author）：
Wei J(*), Ding D, Wang T, Liu Q, Lin Y(*). MiR-338 controls BPA-triggered pancreatic islets insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1. FASEB J. 2017, 31(12):5184-5195.
Lin Y^(#), Ding D^(#), Huang Q, Liu Q, Lu H, Lu Y, Chi Y, Sun X, Ye G, Zhu H, Wei J(*), Dong S(*). Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. BBA-Mol Cell Biol L. 2017, 1862(9):869-882.
Wei J^(#), Sun X^(#), Chen Y, Li Y, Song L, Zhou Z, Xu B, Lin Y(*), Xu S(*). Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet. J Endocrinol, 2014, 222(3):313-325.
Wei J^(#), Zhang Y^(#), Luo Y⁽*⁾, Song D, Dai Y, Wang T, Yuan L⁽*⁾, Wen L, Yang JY⁽*⁾. Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfβ1/2 and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice. Free Radical Bio Med, 2014, 67: 91-102.
Wei J^(#), Lin Y^(#), Li Y, Ying C, Chen J, Song L, Zhou Z, Lv Z, Xia W, Chen X, Xu S⁽*⁾. Perinatal exposure to bisphenol A at reference dose, but not at high dose, predispose rat offspring to metabolic syndrome in adulthood. Endocrinology, 2011, 152(8): 3049-3061.
Lin Y^(#), Wei J^(#), Li Y, Chen J, Zhou Z, Song L, Wei Z, Lv Z, Chen X, Xia W, Xu S⁽*⁾. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol-Endoc M, 2011, 301(3): E527-E538.
主持过的重要课题：
国家自然科学基金青年基金，miR-200a在DEHP暴露致骨骼肌胰岛素抵抗过程中的调控机制研究，2016.01-2018.12.
福建省自然科学基金面上项目，Men1基因调控的表观遗传学修饰在双酚A诱导脂肪细胞分化中的作用研究，2015.04-2018.03.
科研启动经费，DEHP通过miRNA靶向作用胰岛素信号通路致胰岛素抵抗的分子机制探讨，2015.01-2015.12.
中国博士后科学基金，2012M511446、HBx通过抑制AKR7A诱导肝细胞恶性转化的机制研究，2012.05-2013.10.
所有论文列表：
1. Wei J, Ding D, Wang T, Liu Q, Lin Y. MiR-338 controls BPA-triggered pancreatic islet insulin secretory dysfunction from compensation to decompensation by targeting Pdx-1.FASEB J. 2017 Dec;31(12):5184-5195. doi: 10.1096/fj.R. PMID:**
2. Lin Y, Ding D, Huang Q, Liu Q, Lu H, Lu Y, Chi Y, Sun X, Ye G, Zhu H, Wei J, Dong S. Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease.Biochim Biophys Acta. 2017, 1862(9):869-882. doi: 10.1016/j.bbalip.2017.05.001. PMID:**
3. Wang T, Hou J, Li Z, Zheng Z, Wei J, Song D, Hu T, Wu Q, Yang JY, Cai JC. miR-15a-3p and miR-16-1-3p Negatively Regulate Twist1 to Repress Gastric Cancer Cell Invasion and Metastasis.Int J Biol Sci. 2017, 13(1):122-134. doi: 10.7150/ijbs.14770.
4. Jiang C, Chen X, Alattar M,Wei J, Liu H. MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer.Cancer Gene Ther. 2015 Jun;22(6):291-301. doi: 10.1038/cgt.2015.19. PMID: **
5. Wei J, Sun X, Chen Y, Li Y, Song L, Zhou Z, Xu B, Lin Y, Xu S. Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet.J Endocrinol. 2014, 222(3):313-25. doi: 10.1530/JOE-14-0356. PMID:**
6. Gao SB, Xu B, Ding LH, Zheng QL, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH.The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma.J Hepatol. 2014, 61(4):832-9. doi:10.1016/j.jhep. PMID: **
7. Luo Y, Liu Y, Liu M, Wei J, Zhang Y, Hou J, Huang W, Wang T, Li X, He Y, Ding F, Yuan L, Cai J, Zheng F, Yang JY. Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice.Biochim Biophys Acta. 2014, 1839(2):97-106. doi: 10.1016/j.bbagrm. PMID:**
8. Wei J, Zhang Y, Luo Y, Wang Z, Bi S, Song D, Dai Y, Wang T, Qiu L, Wen L, Yuan L, Yang JY. Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfβ1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice.Free Radic Biol Med. 2014, 67:91-102. doi: 10.1016/j. freeradbiomed. PMID:**
9. Lin Y, Sun X, Qiu L,Wei J, Huang Q, Fang C, Ye T, Kang M, Shen H, Dong S. Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells.Cell Death Dis. 2013,17;4:e460. doi: 10.1038/cddis.2012.206.PMID:**
10. Lv Z, Li G, Li Y, Ying C, Chen J, Chen T, Wei J, Lin Y, Jiang Y, Wang Y, Shu B, Xu B, Xu S. Glucose and lipid homeostasis in adult rat is impaired by early-life exposure to perfluorooctane sulfonate.Environ Toxicol. 2013,28(9):532-42. doi: 10.1002/tox.20747. PMID:**
11. Song L, Xia W, Zhou Z, Li Y, Lin Y, Wei J, Wei Z, Xu B, Shen J, Li W, Xu S. Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets.J Endocrinol. 2012,215(2):303-11. doi: 10.1530/JOE-12-0219. PMID:**
12. Wei Z, Song L, Wei J, Chen T, Chen J, Lin Y, Xia W, Xu B, Li X, Chen X, Li Y, Xu S. Maternal exposure to di-(2-ethylhexyl)phthalate alters kidney development through the renin-angiotensin system in offspring.Toxicol Lett. 2012,212(2):212-21. doi: 10.1016/j.toxlet.2012.05.023.PMID:**
13. Lin Y, Wei J, Li Y, Chen J, Zhou Z, Song L, Wei Z, Lv Z, Chen X, Xia W, Xu S. Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat.Am J Physiol Endocrinol Metab. 2011, 301(3):E527-38. doi: 10.1152/ajpendo.00233.2011. PMID: **
14. Wei J, Lin Y, Li Y, Ying C, Chen J, Song L, Zhou Z, Lv Z, Xia W, Chen X, Xu S. Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet.Endocrinology. 2011, 152(8):3049-61. doi: 10.1210/en.2011-0045. Epub 2011 May 17. PMID: **
15. Zeng HC, Zhang L, Li YY, Wang YJ, Xia W, Lin Y, Wei J, Xu SQ. Inflammation-like glial response in rat brain induced by prenatal PFOS exposure.Neurotoxicology. 2011, 32(1):130-9. doi: 10.1016/j.neuro.2010.10.001. PMID: **
16. Zhang L, Li YY, Zeng HC, Wei J, Wan YJ, Chen J, Xu SQ. MicroRNA expression changes during zebrafish development induced by perfluorooctane sulfonate.J Appl Toxicol. 2011,31(3):210-22. doi: 10.1002/jat.1583. PMID:**
17. Zeng HC, Li YY, Zhang L, Wang YJ, Chen J, Xia W, Lin Y, Wei J, Lv ZQ, Li M, Xu SQ. Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin.Synapse. 2011, 65(3):225-33. doi: 10.1002/syn.20840. PMID:**
18. Wan YJ, Li YY, Xia W, Chen J, Lv ZQ, Zeng HC, Zhang L, Yang WJ, Chen T, Lin Y, Wei J, Xu SQ. Alterations in tumor biomarker GSTP gene methylation patterns induced by prenatal exposure to PFOS.Toxicology. 2010, 274(1-3):57-64. doi: 10.1016/j.tox.2010.05.006.PMID: **
19. Xia W, Li Y, Wan Y, Chen T, Wei J, Lin Y, Xu S. Electrochemical biosensor for estrogenic substance using lipid bilayers modified by Au nanoparticles.Biosens Bioelectron. 2010, 15;25(10):2253-8. doi: 10.1016/j.bios.2010.03.004. PMID: **