刘波LIU Bo, Ph.D.



教授，博导
发育遗传与先天免疫
（Developmental Genetics and Innate Immunity）
课题组长
E-mail：bliu23@xmu.edu.cn
厦门大学，生物科学，学士（2004）；
厦门大学，细胞生物学，硕士（2008）；
美国佛罗里达大学，分子遗传学与微生物学，博士（2012）；
美国约翰霍普金斯大学，霍华德休斯医学研究所，博士后（2013-2016）；
美国德克萨斯大学西南医学中心，霍华德休斯医学研究所，博士后（2016-2018）；
厦门大学生命科学学院，教授（2018-至今）；
厦门大学南强青年拔尖A类人才（2018）
福建省****（2018）。


研究领域（Research Area）
Hippo信号通路是动物发育过程中控制器官大小的核心通路。它在肿瘤发生、干细胞分化、组织器官再生及先天免疫等过程中发挥重要作用。本课题组将以果蝇遗传学为主要手段，深入研究Hippo信号通路在动物发育及先天免疫中的作用机制。同时，我们还将以果蝇遗传筛选为基础，结合细胞生物学及比较基因组学等方法，鉴定新的器官大小调控基因及先天免疫因子。
The highly conserved Hippo signaling pathway plays pivotal roles in organ size control, tumorigenesis, stem cell differentiation, tissue regeneration and innate immunity. Using the genetically tractable Drosophila (fruit fly) as a model organism, our research will focus on how Hippo signaling pathway is involved in animal development and innate immunity. Meanwhile, by coupling Drosophila genetic screens with cell biology and comparative genomics, we will identify conserved factors that engage in organ size control and innate immunity.




代表性论文（Selected Publications）


1. Zheng Y#, Liu B#, Wang L, Lei H, Pulgar Prieto KD, Pan D. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex. Cell Reports. 2017, 21(12):3612-3623. (# co-first author)
2.Liu B,Zheng Y, Yin F, Yu J, Silverman N, Pan D. Toll receptor-mediated Hippo signaling controls innate immunity in Drosophila. Cell. 2016, 164(3): 406-419.
3. Zheng Y, Wang W,Liu B, Deng H, Uster E, Pan D. Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade. Developmental Cell. 2015, 34(6):642-55.
4.Liu B, Behura SK, Clem RJ, Schneemann A, Becnel J, Severson DW, Zhou L. P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophilamelanogaster.Plos Pathogens. 2013, 9(2):e**.
5. Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA, Wu Q. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling. Gut. 2012, 61(5):714-24.
6.Bo Liu, James Becnel, Yanping Zhang, Lei Zhou. Induction of reaperOrtholog mxin Mosquito Midgut Cells Following Baculovirus Infection. Cell Death Differentiation. 2011, 18(8):1337-45.
7. Lin N, Li X, Cui K, Chepelev I, Tie F, Liu B, Li G, Harte P, Zhao K, Huang S, Zhou L. A barrier-only boundary element delimits the formation of facultative heterochromatin in Drosophila melanogasterand vertebrates. Mol Cell Biol. 2011, 31(13):2729-41.
8. Can Zhang, Bo Liu, Guangyao Li, Lei Zhou. Extra sex combs, chromatin, and cancer: Exploring epigenetic regulation and tumorigenesis in Drosophila. Journal of Genetics and Genomics. 2011, 38(10):453-60.
9. Wen-xiu Zhao, Min Tian, Bi-xing Zhao, Gui-deng Li, Bo Liu, Yan-yan Zhan, Hang-zi Chen, Qiao Wu. Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor. Molecular Endocrinology. 2007, 21(12):2877-89.
10.Bo Liu, Jia-fa Wu, Yan-yan Zhan, Hang-zi Chen, Xiao-yan Zhang and Qiao Wu. Regulation of the Orphan Receptor TR3 Nuclear Functions by c-Jun N Terminal Kinase Phosphorylation. Endocrinology. 2007, 148(1): 34-44.
11. Zhao BX, Chen HZ, Lei NZ, Li GD, Zhao WX, Zhan YY, Liu B, Lin SC, Wu Q. p53 mediates the negative regulation of MDM2 by orphan receptor TR3. EMBO J. 2006, 25(24):5703-15.


荣誉及奖励(Honors and Awards)


1. 2016, Invited Speaker of the 3^rdFuture of Cancer Science Symposium, UT MD Anderson Cancer Center
2. 2012, Outstanding Academic Achievement Award, University of Florida
3. 2011, Medical Guild Research Incentive Award, University of Florida
4. 2011, 国家优秀自费留学生奖学金, 中国国家留学基金委员会