欧阳高亮OUYANG GaoliangPh.D.
教授，博士生导师

肿瘤微环境与肿瘤转移（Tissue Microenvironments and Tumor Metastasis）
课题组组长
电话：
E-mail：oygldz@xmu.edu.cn

个人简历
1993, BSc., Nanchang University;
2001, Ph.D., Xiamen University.
1993-1996: Assistant, Jiangxi Medical College;
2001-2003: Assistant Professor, Xiamen University;
2006-2008: Research Scholar, Department of Molecular and Cell Biology, University of California, Berkeley, USA;
2003-2010: Associate Professor, School of Life Sciences, Xiamen University;
2010-Present: Professor, School of Life Sciences, Xiamen University.
1993年毕业于南昌大学生物学系，获学士学位
2001年毕业于厦门大学生命科学学院，获博士学位
1993-1996 江西医学院基础医学部 助教
2001-2003 厦门大学生命科学学院 讲师
2003-2010 厦门大学生命科学学院 副教授
2006.2-2008.1美国加州大学伯克利分校 访问研究
2010-至今 厦门大学生命科学学院 教授
2016-至今 厦门大学****


研究领域（Research Area）
Tumor metastasis is a complex multi-step process, involving dissemination of cancer cells to distant organ sites and their subsequent adaptation to and remodeling of foreign tissue microenvironments. Our research group is mainly devoted to the study of tissue microenvironment and tumor metastasis, and systematically elucidates the function of periotin in inflammatory microenvironments and tumor microenvironments and its regulatory role in tumor metastasis. We will continue to investigate the functions of periostin and other matricellular proteins and their regulatory factors in tissue microenvironment remodeling and tumor metastasis.
肿瘤转移是一复杂的多步骤过程，涉及肿瘤细胞侵袭转移至靶器官、适应并重塑靶器官的组织微环境。本课题组主要致力于组织微环境与肿瘤转移研究，系统阐明了Periostin蛋白在炎症微环境和肿瘤组织微环境中的功能及其对肿瘤转移的调控作用。目前主要研究Periostin等基质蛋白及其调控因子在组织微环境重塑和肿瘤转移中的作用机制。



代表性论著（Selected Publications）
1.Ma H, Wang J, Zhao X, Wu T, Huang Z, Chen D, Liu Y*, Ouyang G*. Periostin promotes colorectal tumorigenesis through integrin-FAK-Src pathway-mediated YAP/TAZ activation. Cell Rep, 2020; 30(3): 793-806.e6. (*Corresponding author).
2.Ma Z, Zhao X, Deng M, Huang Z, Wang J, Wu Y, Cui D, Liu Y, Liu R*, Ouyang G*. Bone marrow mesenchymal stromal cell-derived periostin promotes B-ALL progression by modulating CCL2 in leukemia cells. Cell Rep, 2019; 26(6): 1533-1543.e4.
3.Wu T, Huang J, Wu S, Huang Z, Chen X, Liu Y, Cui D, Song G, Luo Q, Liu F*, Ouyang G*. Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. Matrix Biol, 2018; 66: 81-92.
4.Ma Z, Zhao X, Huang J, Jia X, Deng M, Cui D, Du Z, Fu G*, Ouyang G*, Xiao C*. A critical role of periostin in B-cell acute lymphoblastic leukemia. Leukemia, 2017; 31(8): 1835-1837.
5.Cui D, Huang Z, Liu Y, Ouyang G*. The multifaceted role of periostin in priming the tumor microenvironments for tumor progression. Cell Mol Life Sci, 2017; 74(23): 4287-4291.
6.Wang Z, Xiong S, Mao Y, Chen M, Ma X, Zhou X, Ma Z, Liu F, Huang Z, Luo Q, Ouyang G*. Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis. J Pathol, 2016; 239(4): 484-495.
7.Li Y, Wu S, Xiong S, Ouyang G*. Deficiency of periostin protects mice against methionine-choline-deficient diet-induced nonalcoholic steatohepatitis. J Hepatol, 2015; 62(2): 495-497.
8.Huang Y, Liu W, Xiao H, Maitikabili A, Lin Q, Wu T, Huang Z, Liu F, Luo Q, Ouyang G*. Matricellular protein periostin contributes to hepatic inflammation and fibrosis. Am J Pathol, 2015; 185(3): 786-797.
9.Wu T, Luo Q*, Ouyang G*. Periostin: a potent chemotactic factor for recruiting tumor-associated macrophage. Protein Cell, 2015; 6(4): 235-237.
10.Wu T, Wu S, Ouyang G*. Periostin: a new extracellular regulator of obesity-induced hepatosteatosis. Cell Metab, 2014; 20(4): 562-564. (Preview)
11.Liu AY, Zheng H, Ouyang G*. Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix Biol, 2014; 37: 150-156.
12.Wu T, Ouyang G*. Matricellular proteins: multifaceted extracellular regulators in tumor dormancy. Protein Cell, 2014; 5(4): 249-252.
13.Liu AY, Cai Y, Mao Y, Lin Y, Zheng H, Wu T, Huang Y, Fang X, Lin S, Feng Q, Huang Z, Yang T, Luo Q*, Ouyang G*. Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24. Carcinogenesis, 2014; 35(3): 537-545.
14.Liu AY, Ouyang G*. Tumor angiogenesis: glioblastoma stem cells as a new source of pericytes. Curr Biol, 2013; 23(13): R565-R568.
15.Wang X, Liu J, Wang Z, Huang Y, Liu W, Zhu X, Cai Y, Fang X, Lin S, Yuan L, Ouyang G*. Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells. PLoS One, 2013; 8(8): e72962.
16.Wang Z, Ouyang G*. Periostin: a bridge between cancer stem cells and their metastatic niche. Cell Stem Cell, 2012; 10(2): 111-112. (Preview)
17.Fang X, Cai Y, Liu J, Wang Z, Wu Q, Zhang Z, Yang CJ, Yuan L, Ouyang G*. Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene, 2011; 30(47): 4707-4720.
18.Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF*. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 2004; 5(4): 329-339.