陈小芬 CHEN Xiaofen,Ph.D.
教授/博导
国家优秀青年科学基金获得者
福建省高校新世纪优秀人才
神经科学
电 话:
E-mail:chenxf@xmu.edu.cn


教育及工作经历
2000–2004：厦门大学生命科学学院，生物科学学士
2004–2009：中科院上海生化与细胞研究所，生化与分子生物学博士
2009 - 2012：美国加州大学洛杉矶分校（UCLA），博士后

2014 - 2015：美国梅奥医学中心（Mayo Clinic），访问****
2012.11 – 2018.10：厦门大学，副教授
2018.11-至今：厦门大学，教授


研究领域（Research Area）
阿尔茨海默病（Alzheimer’s Disease, AD）是一种以渐进性认知功能丧失为主要特征的神经退行性疾病，是最为常见的老年痴呆类型。目前AD的发病机制尚未完全阐明，也没有治疗AD的有效药物。载脂蛋白E（Apolipoprotein E，ApoE）和髓细胞触发受体2（triggering receptor expressed on myeloid cells 2 ，TREM2）是目前发现的、与AD发生风险最为相关的两个基因。我们拟结合生化、分子、遗传、细胞生物学、电生理以及动物行为学等手段，阐明apoE和TREM2影响AD发生和发展的分子机制，开发潜在的AD治疗药物。


代表性论文（Selected Publications, * Corresponding author）
1. Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Martens YA, Shinohara M, Liu CC, Du D, Sun H, Wen L, Xu H, Bu G, Chen XF (2019). Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model. Nat Commun. DOI: 10.1038/s41467-019-09118-9.
2. Sun F, Chronis C, Kronenberg M, Chen XF, Su T, Lay FD, Plath K, Kurdistani SK, Carey MF (2019). Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods. Mol Cell. 73(2):250-263.e5.
3. Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF (2018). Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2). Molecular Neurodegeneration. 13(1):15.
4. Zhong L*, Chen XF*,^§, Wang TT, Wang Z, Liao CY, Wang ZQ, Huang RZ, Wang DX, Li XX, Wu LB, Zheng HH, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer, Xu H, Bu G§ (2017). Soluble TREM2 promotes microglial survival and induces inflammatory responses via distinct signaling pathways. J Exp Med. 214(3):597-607. (*co-first author; §corresponding author)

5. Zhong L, Zhang ZL, Li XX, Liao CY, Mou PF, Wang TT, Wang ZQ, Wang Z, Wei M, Xu H, Bu G, Chen XF (2017). TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Front. Aging Neurosci. 9:204.
6.Yang L*, Liu CC*, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF^§, Bu G^§ (2016). LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways. J Neuroinflammation. 13(1):304.
7. Kang RR, Li P, Wang TT, Li XX, Wei ZC, Zhang ZL, Zhong L, Cao LL, Heckman MG, Zhang YW, Xu H, Huang CM, Bu G, Chen XF (2016). Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population. Scientific Reports 6:19930.
8. Zhong L, Xie YZ, Cao TT, Wang Z, Wang T, Li X, Shen RC, Xu H, Bu G, Chen XF (2016). A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism. Molecular Neurodegeneration. 11(1):2.
9. Zhong L*, Chen XF*,^§, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G§ (2015). DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response. J Biol Chem.290(25):15866-77.
10. Chen XF^§, Zhang YW, Xu H, Bu G^§. (2013). Transcriptional regulation and its misregulation in Alzheimer's disease. Molecular Brain. 6(1):44-53.
11. Chen XF, Lehmann L., Lin J., Vashisht A., Schmidt, Ferrari R., Huang CY., McKee R., Mosley A., Plath K., Kurdistani S., Wohlschlegel J., Carey M.^§ (2012). Mediator and SAGA Have Distinct Roles in Pol II Preinitiation Complex Assembly and Function. Cell Reports 2:1061-1067.
12. Chen XF, Kuryan B., Kitada T., Tran N., Li B., Carey M. (2012). The Rpd3 Core Complex is a Chromatin Stabilization Module. Current Biology 22(1):1-8.
13. Chen XF, Meng FL, Zhou JQ (2009). Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae. PLoS Genetics 5(6): e**.