张亮 Zhang Liang, Ph.D.
副教授 博士生导师
课题组组长
电话：+86-
E-mail: LZHANGXMU@xmu.edu.cn

2003年，武汉大学获学士学位；
2008年，中国科学院上海生命科学院获博士学位；
2008-2009年，中国科学院上海生命科学院助理研究员；
2009-2014年，美国德州大学西南医学中心博士后；
2014年至今，厦门大学生命科学学院，副教授。

2003, B.S., Wuhan University;
2008, Ph.D., Shanghai Institutes for Biological Science, Chinese Academy Science
2008-2009, Assistant Investigator, Shanghai Institutes for Biological Science, Chinese Academy Science
2009-2014, Postdoctoral Fellow, UT Southwestern Medical Center, Dallas, USA
2014-Present, Associate Professor, School of Life Sciences, Xiamen University

研究领域（Research Area）
核糖核酸在细胞核中被转录，而蛋白质在细胞质中被翻译合成。蛋白质与核酸通过核孔复合体实现细胞核与细胞质之间的穿梭。核质转运对于正常和病理状态下的细胞都具有重要的调节功能。核孔蛋白作为核孔复合体的成员，参与核质转运的调控。实验室的研究兴趣集中于核质运输以及核孔蛋白在抗病毒防御和神经发育与再生过程中的生理功能和作用机制。


Our laboratory studies the functions of nucleo-cytoplasmic trafficking during neural development and antiviral defense. mRNA is transcribed in nucleus and transported to cytoplasm for translation. Proteins, such as transcription factors, need to be transported into nucleus to exert their functions. The trafficking of proteins and mRNA in and out of nucleus occurs through Nuclear Pore Complex (NPC). Nucleoporins are components of NPCs and involved in nucleo-cytoplasmic transport. We mainly focus on whether and how nucleo-cytoplasmic trafficking regulates neural development and innate immunity.



代表性论文(Selected Publications)
1. Zhang, K., Y. Xie, R. Munoz-Moreno, J. Wang, L. Zhang, M. Esparza, A. Garcia-Sastre, B.M.A. Fontoura, and Y. Ren, (2019) Structural basis for influenza virus NS1 protein block of mRNA nuclear export. Nat Microbiol,4,1671-1679
2. Liu, Z., M. Yan, Y. Liang, M. Liu, K. Zhang, D. Shao, R. Jiang, L. Li, C. Wang, D.R. Nussenzveig, S. Chen, C. Zhong, W. Mo, B.M.A. Fontoura, and L. Zhang^#,Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination. Neuron, 2019. 102(3): p. 587-601 e7.
3. Zhang, L^#., J. Wang, R. Munoz-Moreno, M. Kim, R. Sakthivel, W. Mo, D. Shao, A. Anantharaman, A. Garcia-Sastre, N.K. Conrad, and B.M.A. Fontoura# (2018). Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting. Journal of virology . 10.1128/JVI.01634-18 (#: co-correspondence)
4. Thais G.Moreira*, Liang Zhang*, Lihi Shaulov, Amnon Harel, Sharon K. Kuss, Jessica Williams, John Shelton, Bandarigoda Somatilaka, Joachim Seemann, Jue Yang, Ramanavelan Sakthivel, Daniel R. Nussenzveig, Ana M.C.Faria, Beatriz M.A.Fontoura (2015) Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo. Scientific Reports. 5, 17655; doi: 10.1038/srep17655 (2015). (*: equal contribution)
5.Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, Mckay RM, Lev D, Le LQ, Parada LF (2013) CXCR4/ CXCL12 mediate autocrine cell cycle progression in NF1- associated malignant peripheral nerve sheath tumors. Cell152(5):1077-90.
6.Zhang L,Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM. (2012) Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. Journal of Cell Biology; 196(3):315-26 Featured and highlighted by Journal of Cell BiologyFeb, 2012
7. Mo W*, Zhang L*,Yang G, Zhai J, Hu Z, Chen Y, Chen X, Hui L, Huang R, Hu G. (2008) Nuclear ?-Arrestin1 Functions as a Scaffold for the Dephosphorylation of STAT1 and Moderates the Antiviral Activity of IFN-γ. Molecular Cell, 31, 695-707,
(*: equal contribution) Commented by Molecular Cell, Nature China and A-IMBN