吴甜甜Tiantian Wu, Ph.D.
助理教授
肿瘤微环境与肿瘤转移（Tumor Microenvironment and Tumor Metastasis）
E-mail：wutiantian@xmu.edu.cn


2014，厦门大学生物技术专业，学士学位
2019，厦门大学细胞生物学专业，博士学位
2017-2019，美国加州大学伯克利分校，联合培养博士
2019-2020，美国加州大学伯克利分校，博士后
2021年至今，厦门大学生命科学学院，助理教授
2014, B.Sc., Biotechnology, Xiamen University
2019, Ph.D., Cell Biology, Xiamen University
2017-2019, Joint training Ph.D., University of California, Berkeley
2019-2020, Postdoctoral Fellow at University of California, Berkeley
2021-present, School of Life Sciences, Xiamen University, Assistant Professor


研究领域（Research Area）
利用不同肿瘤小鼠模型，从相分离角度，基因转录调控角度，炎症纤维化等角度研究肿瘤微环境与肿瘤转移。
Use different tumor mouse models to study tumor microenvironment and tumor metastasis from the perspective of phase separation, gene transcription regulation, inflammation, fibrosis, etc.


代表性论文（Selected Publications）
1. Lu Y^#, Wu T^#, Gutman O, Lu H, Zhou Q, Henis YI, Luo K*. Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression. Nature Cell Biology, 2020; 22:453-464. (Highlighted in News & Views by Nature Cell Biology; Recommended by F1000)
2.Wu T^#, Huang J^#, Wu S^#, Huang Z^#, Chen X, Liu Y, Cui D, Song G, Luo Q, Liu F*, Ouyang G*. Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. Matrix Biology, 2018; 66:81-92.
3. Ma H, Wang J, Zhao X, Wu T, Huang Z, Chen D, Liu Y*, Ouyang G*. Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation. Cell Report, 2020; 30(3):793-806.
4. Huang Y^#, Liu W^#, Xiao H^#, Maitikabili A, Lin Q, Wu T, Huang Z, Liu F, Luo Q, Ouyang G*. Matricellular protein periostin contributes to hepatic inflammation and fibrosis. The American Journal of Pathology, 2014; 185(3):786-97.
5. Liu AY^#, Cai Y^#, Mao Y^#, Lin Y, Zheng H, Wu T, Huang Y, Fang X, Lin S, Feng Q, Huang Z, Yang T, Luo Q*, Ouyang G*. Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24. Carcinogenesis, 2014; 35(3):537-45.
6. Wu T, Wu S, Ouyang G*. Periostin: a new extracellular regulator of obesity-induced hepatosteatosis. Cell Metabolism, 2014; 20(4):562-4. (Previews)
7. Wu T, Luo Q*, Ouyang G*. Periostin: a potent chemotactic factor for recruiting tumor-associated macrophage. Protein Cell, 2015; 6(4):235-7. (News and views)
8. Wu T, Ouyang G*. Matricellular proteins: multifaceted extracellular regulators in tumor dormancy. Protein Cell, 2014; 5(4):249-52c. (Perspective)