侯永强，HOU Yongqiang, Ph.D.
助理教授
器官大小调控与肿瘤形成(Organ Size Control and Tumorigenesis)
E-mail：houyongqiang@xmu.edu.cn



2014年，天津医科大学生物医学工程专业，学士学位；
2020年，天津医科大学医学生物化学与分子生物学专业，医学博士学位；
2020年至今，厦门大学生命科学学院，助理教授。
2014, B.Sc., Biomedical-Engineering, Tianjin Medical University ;
2020, Ph.D., Medical Biochemistry and Molecular Biology, Tianjin Medical University ;
2020-present, School of Life Sciences, Xiamen University, Assistant Professor.




研究领域（Research Area)
侯永强博士之前的研究主要集中在转录调控和肿瘤发生方面，现在是陈兰芬教授团队的助理教授。团队现在主要的研究方向是阐明Hippo信号通路的关键组分Mst1 和Mst2 激酶在器官大小以及肿瘤形成过程中的功能和调控过程，同时进一步探讨Mst1/2激酶的上下游组分和具体的生物学功能。
Dr. Yongqiang Hou’s previous work was focus on gene transcription regulation and tumorigenesis. He now works as an assistant professor in Lanfen Chen’s Lab. Our research group aims to explore the function of MST kinases in organ size control and tumorigenesis, which are the key kinases of the Hippo signaling pathway. The identification of the novel upstream and downstream regulators of the Mst1/2 kinases for each of these functions is the focus of present effort.




代表性论文( Selected publications)
1.Yongqiang Hou^#, Wei Liu, Xianfu Yi, Yang Yang, Dongxue Su, Wei Huang, Hefen Yu, Xu Teng, Ying Yang, Wei Feng, Tao Zhang, Jie Gao, Kai Zhang, Rongfang Qiu, and Yan Wang*. PHF20L1 as a Novel H3K27me2 Reader Coordinates with Transcriptional Repressors to Promote Breast Tumorigenesis. Sci Adv. 2020 Apr 15;6(16):eaaz0356.
2.Yi Zeng^#, Rongfang Qiu^#, Yang Yang^#, Tianyang. Gao, Yu Zheng, Wei Huang, Jie Gao, Kai Zhang, Ruiqiong Liu, Shuang Wang, Yongqiang Hou, Wenqian Yu, Shuai Leng, Dandan Feng, Wei Liu, Xi Zhang and Yan Wang*. Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis. Cell Rep. 2019 Nov 5;29(6):1482-1498.e4.
3.Wenqian Yu^#, Wei Huang, Yang Yang, Rongfang Qiu, Yi Zeng, Yongqiang Hou, Gancheng Sun, Hang Shi, Shuai Leng, Dandan Feng, Yang Chen, Shuang Wang, Xu Teng, Hefeng Yu and Yan Wang*. "GATA3 recruits UTX for gene transcriptional activation to suppress metastasis of breast cancer." Cell Death & Dis. 2019 Nov 4;10(11):832.
4.Yang Yang^#, Wei Huang^#, Rongfang Qiu, Ruiqiong Liu, Yi Zeng, Jie Gao, Yu Zheng, Yongqiang Hou, Shuang Wang, Wenqian Yu, Shuai Leng, Dandan Feng and Yan Wang*. LSD1 coordinates with the SIN3A/HDAC complex and maintains sensitivity to chemotherapy in breast cancer. J Mol Cell Biol, 2018 Aug 1; (4): 285-301.
5.Liu Ruiqiong^#, Jie Gao^#, Yang Yang, Rongfang Qiu, Yu Zheng, Wei Huang, Yi Zeng, Yongqiang Hou, Shuang Wang, Shuai Leng, Dandan Feng, Wenqian Yu, Gancheng Sun, Hang Shi, Xu Teng and Yan Wang*. PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis. Nucleic Acids Res, 2018 Jul; 46(13): 6608-6626.
6.Lin Shan^#, Xing Zhou, Xinhua Liu, Yue Wang, Dongxue Su, Yongqiang Hou, Na Yu, Chao Yang, Beibei Liu, Jie Gao, Yang Duan, Jianguo Yang, Wanjin Li, Jing Liang, Luyang Sun, Kexin Chen, Chenghao Xuan, Lei Shi, Yan Wang*, and Yongfeng Shang*. FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis. Cancer Cell, 2016 Nov 14; 30(5):708-722.