曾涛玲Zeng Taoling, Ph.D.
特任副研究员
E-mail：zengtaoling@xmu.edu.cn
简历 (Education and Work experience)


2009年，西南大学生物科学专业，学士学位；
2014年，厦门大学细胞生物学专业，博士学位；
2015年-2019，厦门大学生命科学学院，工程师；
2019年，厦门大学生命科学学院，助理教授；
2021年-至今，厦门大学生命科学学院，特任副研究员；
B.S., Southwest University, 2009
Ph.D., Xiamen University, 2014
Engineer, School of Life Sciences, Xiamen University, 2015
Assistant Professor, School of Life Sciences, Xiamen University, 2019



研究领域（Research Area）
蛋白翻译后修饰与肿瘤发生发展：蛋白质的泛素化和类泛素化修饰对于调节各种细胞和机体生物学活性都起着十分重要的作用，其调控的紊乱会导致包括神经退行性疾病和癌症在内的多种重大疾病的发生。我们致力于研究蛋白质泛素化和类泛素化修饰在调控细胞生长、死亡、自噬以及肿瘤发生发展中的作用和分子机理。同时，在分子机理研究的基础上，以在肿瘤发生发展中起重要作用的泛素连接酶为靶点，进行抗肿瘤新型靶向药物的研发，以期获得癌症治疗的新的先导化合物。
Protein post-translational modifications such as ubiquitination and ubiquitin-like modification are key regulatory mechanisms that control various biological processes. Dysregulation of protein modification results in development of many human diseases like neurodegenerative disease and cancer. Our research interest has been focused on mechanism studies of ubiquitination and ubiquitin-like modification in regulation of cell proliferation, cell death, autophagy, and tumorigenesis. We are also working on identifying small-molecule modulators of E3 ubiquitin ligases that are critical for cancer development, which is emerging as a promising drug discovery strategy.



代表性论文 (Selected Publications)(* Corresponding author)：
1.Maoyuan Tian^#, Taoling Zeng^#, Mingdong Liu, Shang Han, Huayue Lin, Qi Lin, Li Li, Tingting Jiang, Gao Li, Hong Lin, Ting Zhang, Qiaofeng Kang, Xianming Deng*, Hong-Rui Wang*. A cell-based high-throughput screening method for modulators of E3 ligases using ubiquitin-reference-technique (URT) technique. J Biol Chem, 2019, 294(8): 2880-2891.
2.Mingdong Liu^#, Taoling Zeng^#, Xin Zhang^#, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao*, Hong-Rui Wang*.ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. Nature Communications, 2018, 9:4139.
3.Zeng T^#, Wang Q^#, Fu J^#, Lin Q, Bi J, Ding W, Qiao Y, Zhang S, Zhao W, Lin H,Wang M, Lu B, Deng X, Zhou D, Yin Z*, Wang HR*.Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis. Cell Reports, 2014,7(3):871-82.
4.Wang M^#, Guo L^#, Wu Q^#, Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, RenL, Zhang S, Pei Y, Yin Z, Ding F, Wang HR*.ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.Nature Communications, 2014, 5:4901.