邹懿，1983年12月生。博士，教授，博士生导师。


国家级人才计划青年项目（2018）。第三批重庆市学术技术带头人（2019）。中央党校（国家行政学院）青年英才班学员（2019）。重庆市教育系统优秀共产党员（2019）。重庆市****基金获得者（2020）。
2002-2009年于西南大学药学院，分别获制药工程学士和微生物与生化药学硕士学位。2013年于上海交通大学微生物代谢国家重点实验室获生物学博士学位，研究方向为链霉菌来源的复杂结构天然产物生物合成，博士学位论文获上海市优秀博士学位论文奖。2014年-2017年，在美国加州大学洛杉矶分校（UniversityofCalifornia,LosAngeles,UCLA）从事博士后研究工作，研究方向为真菌来源的复杂结构天然产物酶学合成和催化机理。2017年7月，通过西南大学“聚贤工程”人才引进加入药学院任职。近几年来，以通讯作者或第一作者身份在包括Nat.Chem.Biol.,Chem.Rev.,J.Am.Chem.Soc.,Angew.Chem.Int.Ed.,ACSCatal.,Org.Lett.,Acta.Pharm.Sin.B.等国际著名期刊上发表文章数篇，相关成果入选webofscience高被引论文，被权威综述性杂志Nat.Prod.Rep.遴选为年度研究热点报道，同时被生物医学论文评价系统F1000Prime评为杰出论文而被强烈推荐。

热忱欢迎有志于真菌药用天然产物合成生物学与生物酶工程相关研究的
青年教师、博士后、研究生和本科生加入课题组！

联系方式
E-mail:zouyi31@swu.edu.cn
教育与工作经历
2017.07-至今 西南大学药学院，教授，博士生导师
2014.01-2017.01美国加州大学洛杉矶分校，博士后
2009.09-2013.12上海交通大学，微生物代谢国家重点实验室，生物学，博士
2006.09-2009.07西南大学药学院，微生物与生化药学，硕士
2002.09-2006.07西南大学药学院，制药工程，学士
课题组研究方向
1.真菌天然药物合成生物学与生物酶工程
2.基于药物靶标基因组挖掘的真菌天然药物发现
3.农作物病原真菌天然产物酶学与化学生态学
课题组承担的课题
1.国家自然基金委面上项目（2022. 01-2025. 12，**，主持）
2.重庆市****科学基金项目（2020.09-2023.08，cstc2020jcyj-jqX0005，主持）
3.科技部重点研发计划子课题（2020.11-2025.10，2020YFA**，主持）
4.国家自然基金委面上项目（2019.01-2022.12，**，主持）
5.重庆市留学生创新创业计划重点项目（2018.01-2020.12，cx**，主持）
6.国家级人才计划青年项目（A类资助）
7.中央高校业务费重点项目（2018.04-2019.12，XDJK2018B035，主持）
8.西南大学“聚贤工程”人才启动基金（2017.07-2020.12，SWU117034，主持）
学术机构任职
1.中国菌物学会药用真菌专业委员会，副主任委员
2.《药学学报》中英文两刊青年编委
3. 《GreenSynthesis&Catalysis》青年编委
4. 《Chinese Journal of Natural Medicines》青年编委


论文发表
http://orcid.org/0000-0002-1742-9650
@SWU独立成立课题组以来（2017.07-）
1. Cai, Y., Rao, L., Zou, Y.* Genome Mining Discovery of a C₄?Alkylated Dihydroisocoumarin Pathway in Fungi. Org. Lett. 2021, 23, 2337–2341.
2. Wei, Q., Zeng, H-C., Zou, Y.* Divergent Biosynthesis of Fungal Dioxafenestrane Sesquiterpenes by the Cooperation of Distinctive Baeyer–Villiger Monooxygenases and α-Ketoglutarate-Dependent Dioxygenases. ACS Catal. 2021, 11, 948-957.
3. Zhang, J-M., Wang, H-H., Liu, X., Hu, C-H., Zou, Y.* Heterologous and Engineered Biosynthesis of Nematocidal Polyketide-Nonribosomal Peptide Hybrid Macrolactone from Extreme Thermophilic Fungi. J. Am. Chem. Soc. 2020, 142, 1957-1965.（荣获首届川渝科技学术大会优秀论文二等奖）
4. Zeng, H-C., Yin, G-P., Wei, Q., Li, D-H., Wang, Y., Hu, Y-C., Hu, C-H.*, Zou, Y.* Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis. Angew. Chem. Int. Ed. 2019, 58, 6569-6573. (Hot o? the Press, Nat. Prod. Rep., 2019, 36, 1039-1043)
5. Feng, C., Wei, Q., Hu, C-H.*, Zou, Y.* Biosynthesis of Diphenyl Ethers in Fungi. Org. Lett. 2019, 21, 3114-3118.
6. Chen, X-W., Wang, L., Zhang, J-M., Jiang, T., Hu, C-H., Li, D-H.*, Zou, Y.* Immunosuppressant Mycophenolic Acid Biosynthesis Employs a New Globin-like Enzyme for Prenyl Side Chain Cleavage. Acta. Pharm. Sin. B. 2019, 9, 1253-1258.
7. Yan, D-J., Chen, Q-B., Gao, J., Bai, J., Liu, B-Y., Zhang, Y-L., Zhang, L., Zhang, C., Zou, Y., Hu, Y-C.* Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Org. Lett. 2019, 21, 1475-1479.
8. Bai, J., Yan, D., Zhang, T., Guo, Y, Liu, Y., Zou, Y., Tang, M-C., Liu, B., Wu, Q., Yu, S.*, Tang, Y.*, Hu, Y-C.* A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew. Chem. Int. Ed. 2017, 56, 4782-4786.
@独立成立课题组之前


9. Zou, Y., Garcia-Borràs, M., Tang, M-C., Hirayama, Y., Li, D., Li, L., Watanabe, K., Houk, K. N.*, Tang, Y.* Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis. Nat. Chem. Biol. 2017, 13, 325-332. (Recommended as the exceptional paper by F1000 Prime)
10. Tang, M-C.^#, Zou, Y.^#, Watanabe, K., Walsh, C. T.*, Tang, Y.* Oxidative Cyclization in Natural Product Biosynthesis. Chem. Rev. 2017, 117, 5226-5333. (^#co-first author, web of science, most-cited papers)
11. Zou, Y., Zhan, Z., Li, D., Tang, M-C., Cacho, R., Watanabe, K., Tang, Y.* Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids. J. Am. Chem. Soc. 2015, 137, 4980-4983. (Hot o? the Press, Nat. Prod. Rep. 2015, 32, 1165-1169)
12. Zou, Y.^#, Xu, W.^#, Tsunematsu, Y., Tang, M-C., Watanabe, K., Tang, Y.* Methylation-dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis. Org. Lett. 2014, 16, 6390-6393. (^#co-first author)
13. Zou, Y., Fang, Q., Yin, H., Liang, Z., Kong, D., Bai, L., Deng, Z., Lin, S.* Stereospecific Biosynthesis of β-Methyltryptophan from l-Tryptophan Features a Stereochemical Switch. Angew. Chem. Int. Ed. 2013, 52, 12951-12955.
14. Zou, Y., Yin, H., Kong, D., Deng, Z., Lin, S.* A Trans-acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248. ChemBioChem 2013, 14, 679-683.
15. Tang, M-C.^#, Zou, Y.^#, Yee, D., Tang, Y.* Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in Penicillium thymicola IBT 5891. AIChE Journal. 2018, 64, 4182-4186. (^#co-first author)
16. Huang, T., Duan, Y., Zou, Y., Deng, Z., Lin, S.* NRPS Protein MarQ Catalyzes Flexible Adenylation and Specific S-Methylation. ACS Chem. Biol. 2018, 13, 2387-2391.
17. Duan, Y., Liu, Y., Huang, T., Zou, Y., Huang, T., Hu, K., Deng, Z., Lin, S.* Divergent biosynthesis of indole alkaloids FR900452 and spiro-maremycins. Org. Biomol. Chem. 2018,16, 5446-5451.
18. Zhang, Y., Zou, Y., Brock, N. L., Huang, T., Lan, Y., Wang, X., Deng, Z., Tang, Y., Lin, S.* Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J. Am. Chem. Soc. 2017, 139, 11887-11894.
19. Liu, N., Hung, Y., Gao, S-S., Hang, L., Zou, Y., Chooi, Y-H.*, Tang, Y.* Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Org. Lett. 2017, 19, 3560-3563.
20. Yu, X., Liu, F., Zou, Y., Tang, M-C., Hang, L., Houk, K. N.*, Tang, Y.* Biosynthesis of Strained Piperazine Alkaloids- Uncovering the Concise Pathway of Herquline A. J. Am. Chem. Soc. 2016, 138, 13529-13532.
21. Li, L., Yu, P., Tang, M-C., Zou, Y., Gao S-S., Hung, Y-S., Zhao, M-X., Watanabe, K., Houk, K. N.*, Tang, Y.* Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase. J. Am. Chem. Soc. 2016, 138, 15837-15840.
22. Han, M.^#, Yin, H.^#, Zou, Y., Brock, N. L., Huang, T., Deng, Z., Chu, Y.*, Lin, S.* An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catal. 2016, 6, 788-792.
23. Lan, Y., Zou, Y., Huang, T., Wang, X., Brock, N. L., Deng, Z., Lin, S.* Indole Methylation Protects Diketopiperazine Configuration in the Maremycin Biosynthetic Pathway. Sci. China. Chem. 2016, 59, 1224-1228.
24. Kong, D., Zou, Y., Zhang, Z., Xu, F., Brock, N. L., Zhang, L., Deng, Z., Lin, S.* Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin. Sci. Rep. 2016, 6, 20273.
25. Tang, M-C., Lin, H-C., Li, D., Zou, Y., Li, J., Xu, W., Cacho, R. A., Hillenmeyer, M., Garg, N. K., Tang, Y.* Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. J. Am. Chem. Soc. 2015, 137, 13724-13727.
26. Wang, H., Zhang, H., Zou, Y., Mi, Y., Lin, S., Xie, Z., Yan, Y., Zhang, H.* Structural Insight into the Tetramerization of an Iterative Ketoreductase SiaM through Aromatic Residues in the Interfaces. PloS ONE. 2014, 9, e97996.?