陆军教授, 博士，西南大学药学院药理教研室主任

教育经历
1988-1992年 四川大学化学系 学士学位
1992-1995年 四川大学化学系 硕士学位
1995-1998年 中科院长春应用化学研究所博士学位
科研经历
1999-2000年 中科院长春应用化学研究所 助理研究员,
2000-2002年 日本理化学研究所 STA、JSPS博士后
2003-2005 年 瑞典卡罗琳斯卡医学院 博士后
2005-2009 年 瑞典卡罗琳斯卡医学院 研究员
2009-2013 年 瑞典卡罗琳斯卡医学院 助理教授
2013-2016 年 瑞典卡罗琳斯卡医学院 高级研究员
2016年6月- 西南大学药学院 教授
2018年3月- 西南大学药学院 药理教研室主任
研究内容和成果
主要从事以生物抗氧化体系（硫氧还蛋白体系、谷胱甘肽体系、硒蛋白等）为靶向的新型抗生素、抗癌药物、抗神经退行性疾病的药物作用机制的研究及新药开发。
在PNAS、EMBO Molecular Medicine、Cancer Research等刊物上发表50余篇SCI论文，被引用3800余次，H-index 27，获1项美国发明专利授权。
学术荣誉和兼职
为药学类国际刊物Biomedicine & Pharmacotherapy、Current Pharmaceutical Biotechnology的编委、Current Medicinal Chemistry的客座编辑
教学
承担全英文班药理学、分析化学的教学

研究组成员及活动

陆军 教授

瑞典皇家科学院院士Arne Holmgren教授访问实验室并在缙云山留影

英国巴斯大学Chararah Pourzand博士和研究组成员一起郊游

欢迎有志于新药研究开发的学生、博士后加盟本研究组！
联系地址E-mail: junlu@swu.edu.cn

代表性文章
1. Ouyang Y, Peng Y, Li J, Holmgren A, Lu J*. Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems. Metallomics. 2018, 10(2):218-228. (*通讯作者，下同)
2. Ren X, Zou L, Lu J, Holmgren A. Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic.Free Radic Biol Med. 2018 May 25. pii: S0891-5849(18)30914-6. doi: 10.1016/j.freeradbiomed.2018.05.081.
3. Zou L, Lu J*, Wang J, Ren X, Zhang L, Gao Y, Rottenberg ME, Holmgren A*. Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections. EMBO Mol Med. 2017, 9(8):1165-1178.
4. Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho C, Holmgren A, Lu J*. Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System. Antioxid Redox Signal. 2017, 27(13):989-1010
5. álvarez-Zaldiernas C, Lu J*, Zheng Y, Yang H, Blasi J, Solsona C*, Holmgren A*. Cellular Redox Systems Impact the Aggregation of Cu, Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis. J Biol Chem., 2016, 291(33):17197-17208.
6. Olivera C, Ren X, Vodnala SK, Lu J, Coppo L, Leepiyasakulchai C, Holmgren A, Kristensson K, Rottenberg M, Nitric oxide protects the integrity of the blood-brain barrier during the infection with Trypanosoma brucei, PLoS Pathog, 2016, 12(2): e**.
7. Zhang X, Lu J*, Ren X, Du Y, Zheng Y, Ioannou PV, Holmgren A*, Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1. Free Radic Biol Med. 2015, 89:192-200.
8. Lu J, Holmgren A, The thioredoxin superfamily in oxidative protein folding, Antioxid Redox Signal, 2014, 457-470.
9. Lu J*, Holmgren A*, The thioredoxin antioxidant system. Free Radic Biol Med, 2014, 66: 75-87.
10.Lu J, Vodnala SK, Gustavsson AL, Gustafsson TN, Sj?berg B, Johansson HA, Kumar S, Tjernberg A, Engman L, Rottenberg ME, Holmgren A, Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei, J Biol Chem, 2013, 288(38): 27456-27468.
11.Lu J, Vlamis-Gardikas A, Kandasamy K, Zhao R, Gustafsson TN, Engstrand L, Hoffner S, Engman L, Holmgren A, Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione, FASEB J, 2013, 27(4): 1394-1403.
12.Lu J, Holmgren A, Thioredoxin system in cell death progression, Antioxid Redox Signal, 2012, 17(12): 1738-1747.
13.Zhang X, Zheng YJ, Fried LE, Du Y, Montano SJ, Sohn A, Lefkove B, Holmgren L, Arbiser JL, Holmgren A*, Lu J*, Disruption of mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes, Free Radical Biology & Medicine, 2011, 50(7): 811-20.
14. Holmgren A, Lu J, Thioredoxin and thioredoxin reductase: Current research with special reference to human disease, BBRC, 2010, 396(1): 120-124.
15.Lu J*, Zhong L, L?nn ME, Burk RF, Hill KE, Holmgren A*, Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver, FASEB J, 2009, 23(8): 2394-2402.
16.Lu J, Holmgren A, Selenoproteins. J Biol Chem, 2009, 284(2): 723-727.
17.Lu J, Berndt C, Holmgren A, Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase. Biochim Biophys Acta, 2009, 1790(11): 1513-1519.
18.Lu J, Chew EH, Holmgren A, Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide, Proc Natl Acad Sci U S A, 2007, 104(30): 12288-12293.
19. Papp LV, Lu J, Holmgren A, Khanna KK, From selenium to selenoproteins: Synthesis, identity and their role in human health, Antioxid. Redox Signal, 2007, 9(7): 775-806.
20. Lu J, Papp LV, Fang J, Rodriguez-Neto S, Zhivotovsky B, Holmgren A, Inhibition of mammalian thioredoxin reductase by some flavonoids: Implications for myricetin and quercetin anticancer activity, Cancer Res, 2006, 66(8): 4410-4418.

授权发明专利：

Holmgren A, Lu J, Vlamis-Gardikas A, Zhao R, Kandasamy K, Engman L, Engstrand L, Hoffner S. Bacterial thioredoxin reductase inhibitions and methods for use thereof. U.S. Patent, patent No.: US 2014/** A1. Patent open date：2014.3.27.