张传瑞 Title：研究员/博导
E-mail Address：crzhang@cqu.edu.cn
Tel.：**


个人/团队介绍
学习工作经历
2016.07-至今 研究员，重庆大学，药学院
2012.01-2015.12 博士后，密歇根州立大学，导师Muraleedharan Nair教授
2011.01-2012.01 博士后，亚利桑那大学，导师Leslie Gunatilaka教授
2010.10-2011.01 副研究员，中国科学院上海药物研究所
2008.07-2010.10 助理研究员，中国科学院上海药物研究所
2003.09-2008.07 药物化学博士，中国科学院上海药物研究所，导师岳建民院士
1999.09-2003.07 理学学士，北京师范大学，化学学院

研究领域 1.从药用植物或真菌中发现具有重要生物活性的小分子化合物，以期发现新药先导化合物进而研发新药；
2.从药食两用植物或功能性食品中发现活性物质，以期阐明其药用或者功能性作用机制进而开发保健品；
3.利用现代科学的理论和手段阐述传统中药的药效物质基础和药理作用机制实现中药现代化。
项目成果 主持基金
1.国家自然科学基金面上项目，**，2022.01-2025.12，主持
2.中国科学院昆明植物研究所/植物化学与西部植物资源持续利用国家重点实验室开放课题，P2020-KF09，2020.11-2022.10，主持
3.重庆市自然科学基金面上项目，cstc2020jcyj-jqX0009，2020.07-2023.06，主持
4.中央高校基本科研业务费，2020CDJ-LHZZ-006，2020.07-2023.06，主持
5.中国药科大学/天然药物活性组分与药效国家重点实验室开放研究基金，SKLNMKF202011，2020.01-2021.12，主持
6.中央高校基本科研业务费，2020CDJQY-A078，2020.01-2021.12，主持
7.重庆市留学人员回国创新支持计划项目，cx**，019.07-2020.12，主持
8.中国医学科学院药物研究所/天然药物活性物质与功能国家重点实验室开放课题，GTZK201901，2019.05-2021.04，主持
9.中国科学院上海药物研究所/新药研究国家重点实验室开放课题，SIMM1903KF-14，2019.05-2020.04，主持
10.中央高校基本科研业务费，CDJQJ468824，2017.01-2018.12，主持
11.重庆大学“****”人才引进启动项目，2016.07-2022.06，主持
12.国家自然科学基金青年科学基金，**，2010.01-2012.12，主持
13.国家自然科学基金重点项目，**，2010.01-2013.12，课题主持人（项目负责人：中国科学院成都生物研究所张国林研究员）

获奖情况
1.2010年上海市自然科学一等奖（排名第四）
2.2009年中国药学会科学技术奖二等奖（排名第四）
3.2008年上海药学科技奖一等奖（排名第四）
4.2008中国科学院朱李月华优秀博士生奖学金
代表性文章
1. Yu-Xi Chen, Yun-Xia You, Li Rao, Yu Liu, Qian He, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Neolignans and sesquiterpenoid from Piper yunnanense. Chemistry & Biodiversity 2021, DOI: 10.1002/cbdv.. (^#equal contribution)
2. Qian He, Yue Fan, Yu Liu, Li Rao, Yun-Xia You, Yu Su, Zhen Zhou, You-Kai Xu, Chuan-Rui Zhang*. Cryptoyunnanones A?H, complex flavanones from Cryptocarya yunnanensis. Journal of Natural Products 2021, 84, 2209?2216.
3. Li Rao, Yao Li, Qian He, Yu Liu, Yu Su, Yun-Xia You, Yue Fan, Bin Lin, Yi-Nan Zhang, Chuan-Rui Zhang*. Iridoid constituents of Viburnum brachybotryum. Journal of Natural Products 2021, 84, 1915?1923. (^#equal contribution)
4. Yu Liu, Yun-Xia You, Li Rao, Qian He, Yu Su, Yue Fan, Yizhou Li, You-Kai Xu, Chuan-Rui Zhang*. Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity. Chinese Journal of Natural Medicines Accepted.
5. Qian He, Yue Fan, Yu Liu, Yun-Xia You, Li Rao, Yu Su, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Cytotoxic α-pyrone derivatives from Cryptocarya yunnanensis. Natural Product Research 2020, DOI: 10.1080/**.2020.**.
6. Li Rao, Yun-Xia You, Yu Su, Yue Fan, Yu Liu, Qian He, Yi Chen, Jie Meng, Lin Hu, Yizhou Li, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Lignans and neolignans with antioxidant and human cancer cell proliferation inhibitory activities from Cinnamomum bejolghota confirm its functional food property. Journal of Agricultural and Food Chemistry 2020, 68, 8825?8835.
7. Hong-Yan Xu, Ji-Hua Ren, Yu Su, Fang Ren, Yu-Jiao Zhou, Hui Jiang, Sheng-Tao Cheng, Chuan-Rui Zhang*, Juan Chen. Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim. Journal of Ethnopharmacology 2020, 257, 112787.
8. Wei Li, Li Rao, Yu Liu, Qian He, Yue Fan, Yun-Xia You, Yu Su, Feng Hu, You-Kai Xu, Bin Lin, Sheng Yin, Chuan-Rui Zhang*. (±)-Meliviticines A and B: rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity. Bioorganic Chemistry 2019, 90, UNSP 103099.
9. Yue Fan, Yu Liu, Yun-Xia You, Li Rao, Yu Su, Qian He, Feng Hu, Yizhou Li, Weili Wei, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Cytotoxic arylalkenyl α,β-unsaturated δ-lactones from Cryptocarya brachythyrsa. Fitoterapia 2019, 136, 104167.
10. Li Rao, Yun-Xia You, Yu Su, Yu Liu, Qian He, Yue Fan, Feng Hu, You-Kai Xu, Chuan-Rui Zhang*. Two spiroketal derivatives with an unprecedented amino group and their cytotoxicity evaluation from the endophytic fungus Pestalotiopsis flavidula. Fitoterapia 2019, 135, 5–8.
11. Chuan-Rui Zhang*, Wajid Khan, Jehan Bakht, Muraleedharan G. Nair. New antiinflammatory sucrose esters in the natural sticky coating of tomatillo (Physalis philadelphica), an important culinary fruit. Food Chemistry 2016, 196, 726-732.
12. Chuan-Rui Zhang*, Amila A. Dissanayake, Kudret Kevsero?lu, Muraleedharan G. Nair. Evaluation of coriander spice as a functional food by using in vitro bioassays. Food Chemistry 2015, 167, 24-29.
13. Hua Zhang, Chuan-Rui Zhang*, Ying-Shan Han, Mark A. Wainberg, Jian-Min Yue. New Securinega alkaloids with anti-HIV activity from Flueggea virosa. RSC Advances 2015, 5, 107045-107053. (^#equal contribution)
14. Chuan-Rui Zhang*, Amila A. Dissanayake, Muraleedharan G. Nair. Functional food property of honey locust (Gleditsia triacanthos) flowers. Journal of Functional Foods 2015, 18, 266-274.
15. Chuan-Rui Zhang*, Ettannil Jayashree, Paramasivam Suresh Kumar, Muraleedharan G. Nair. Antioxidant and antiinflammatory compounds in nutmeg (Myristica fragrans) pericarp as determined by in vitro assays. Natural Product Communications 2015, 10, 1399-1402.
16. Chuan-Rui Zhang*, Saleh A. Aldosari, Polana S. P. V. Vidyasagar, Karun M. Nair, Muraleedharan G. Nair. Antioxidant and anti-inflammatory assays confirm bioactive compounds in ajwa date fruit. Journal of Agricultural and Food Chemistry 2013, 61, 5834-5840.
17. Chuan-Rui Zhang*, Robert E. Schutzki, Muraleedharan G. Nair. Antioxidant and anti-inflammatory compounds in the popular landscape plant Berberis thunbergii var. atropurpurea. Natural Product Communications 2013, 8, 165-168.
18. Chuan-Rui Zhang*, Hong-Bing Liu, Shi-Hui Dong, Yan Wu, Jian-Min Yue. Alkaloids from the twigs and leaves of Daphniphyllum macropodum. Helvetica Chimica Acta 2013, 96, 499-504.
19. Chuan-Rui Zhang*, Cheng-Qi Fan, Shi-Hui Dong, Hong-Bing Liu, Wen-Bin Zhou, Yan Wu, Jian-Min Yue. Angustimine and angustifolimine, two new alkaloids from Daphniphyllum angustifolium. Organic Letters 2011, 13, 2440-2443. (^#equal contribution)
20. Chuan-Rui Zhang*, Yan Wu, Jian-Min Yue. Polyoxygenated seco-cyclohexene derivatives from Uvaria tonkinensis var. subglabra. Chinese Journal of Natural Medicines 2010, 8, 0084-0087.
21. Chuan-Rui Zhang*, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, Jian-Min Yue. Calycinumines A and B, two novel alkaloids from Daphniphyllum calycinum. Organic Letters 2009, 11, 4692-4695.
22. Chuan-Rui Zhang*, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, Jian-Min Yue. Alkaloids from the leaves of Daphniphyllum subverticillatum. Journal of Natural Products 2009, 72, 1669-1672.
23. Chuan-Rui Zhang*, Sheng-Ping Yang, Yan Wu, Xue-Qin Chen, Xue-Chu Zhen Jian-Min Yue. Limonoids from the twigs and leaves of Chukrasia tabularis. Helvetica Chimica Acta 2008, 91, 2338-2350.
24. Chuan-Rui Zhang*, Sheng-Ping Yang, Yan Wu, Jian-Min Yue. Alkaloids from the twigs of Daphniphyllum calycinum. Journal of Natural Products 2008, 71, 1663-1668.
25. Chuan-Rui Zhang*, Cheng-Qi Fan, Li Zhang, Sheng-Ping Yang, Yan Wu, Yang Lu, Jian-Min Yue. Chuktabrins A and B, two novel limonoids from the twigs and leaves of Chukrasia tabularis. Organic Letters 2008, 10, 3183-3186.
26. Chuan-Rui Zhang*, Sheng-Ping Yang, Jian-Min Yue. Sterols and triterpenoids from the spores of Ganoderma lucidum. Natural Product Research 2008, 22, 1137-1142.
27. Chuan-Rui Zhang*, Sheng-Ping Yang, Shang-Gao Liao, Cheng-Qi Fan, Yan Wu, Jian-Min Yue. Chuktabularins A-D, four new limonoids with unprecedented carbon skeletons from the stem bark of Chukrasia tabularis. Organic Letters 2007, 9, 3383-3386.
28. Chuan-Rui Zhang*, Sheng-Ping Yang, Qiao Zhu, Shang-Gao Liao, Yan Wu, Jian-Min Yue. Nortriterpenoids from Chukrasia tabularis var. velutina. Journal of Natural Products 2007, 70, 1616-1619.
29. Chuan-Rui Zhang*, Sheng-Ping Yang, Shang-Gao Liao, Yan Wu, Jian-Min Yue. Polyoxygenated cyclohexene derivatives from Uvaria rufa. Helvetica Chimica Acta 2006, 89, 1408-1416.