郭键 Title：副教授
E-mail Address：jian.guo@cqu.edu.cn
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个人/团队介绍 郭键，副教授/硕士生导师，2012年6月毕业于北京大学药学院，获得博士学位。先后主持、参与国家自然基金、重庆市自然基金、新药创制重大专项等项目多项，已在J. Med. Chem., Org. Lett.等药物化学、有机化学领域国际权威期刊上发表SCI论文近二十篇，申请专利多项。主要研究方向包括：新型靶向抗生素及抗菌新策略的研发；基于“糖”的药物化学及化学生物学研究。
学习工作经历
研究领域
项目成果
代表性文章 Lagishetti, C.; Banne, S.; You, H.;Tang, M.;Guo, J.*; Qi, N.*; He, Y.*Construction of Bridged-Ring-Fused Naphthalenone Derivatives Through an Unexpected Zn(OTf)₂-Catalyzed Cascade Transformation.Org. Lett.2019,21, 5301-5304.
Liu, Y.; Wang, Z.-P.; Banne, S.;Guo, J.*; He, Y.*Toward the Total Synthesis of Scabrosins: Synthesis of a Desulfur-scabrosin Skeleton and Its Stereoisomers.J. Org. Chem.2019,84, 5838-5845.
Lin, Z.; Xu, X.; Zhao, S.; Yang, X.;Guo, J.; Zhang, Q.; Jing, C.; Chen, S.; He, Yun, Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens.Nat. Commun.2018,9, 3445.
Banne, S.; Reddy, D. P.; Li, W.; Wang, C.;Guo, J.*; He, Y.* A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G.Org. Lett. 2017,19,4996–4999.
Xu, X.-B.; Lin, Z.-H.; Liu, Y.;Guo, J.*; He, Y.*Stevens rearrangement of thioethers with arynes: a facile access to multi-substituted β-keto thioethers.Org. Biomol. Chem.,2017,15, 2716-2720.
Guo, J.; Li, W.; Xue, W.; Ye, X.-S.* Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide.J. Med. Chem.2017,60,2135–2141.
Qi, N.; Zhang, N.; Allu, S. R.; Gao, J.;Guo, J.*; He, Y.* Insertion of Arynes into P–O Bonds: One-Step Simultaneous Construction of C–P and C–O Bonds.Org. Lett.2016,18,6204-6207.
Qi, N.; Allu, S. R.; Wang, Z.; Liu, Q.;Guo, J.*; He, Y.* Asymmetric Total Syntheses of Aetheramides and Their Stereoisomers: Stereochemical Assignment of Aetheramides.Org. Lett.2016,18, 4718-4721.
Guo, J.^#; Kiran, I. C.^#; Reddy, R. S.; Gao, J.; Tang, M.; Liu, Y.; He, Y.* Synthesis of Carbazolequinones by Formal [3+ 2] Cycloaddition of Arynes and 2-Aminoquinones.Org. Lett.2016,18, 2499-2502.
Qi, N.; Wang, Z.; Allu, S. R.; Liu, Q.;Guo, J.*; He, Y.*Total Syntheses of Anti-HIV Cyclodepsipeptides Aetheramides A and B.J. Org. Chem.2016,81, 12466-12471.
Guo, J.; He, Y.*; Ye, X.-S.*Design and Discovery of Sialyltransferase Inhibitors.Prog. Chem.2016,28, 1712-1720.