王震 Title：副教授
E-mail Address：wangz1114@cqu.edu.cn
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个人/团队介绍
学习工作经历 2015年11月－至今：重庆大学药学院（创新药物研究中心），专任教师/副教授；
2014年8月－2015年11月：新加坡国立大学，博士后，导师：Prof. Lu Yixin；
2009年9月－2014年7月：四川大学化学学院，理学博士，导师：冯小明院士；
2005年9月－2009年6月：四川大学化学学院，理学学士，导师：冯小明院士。


研究领域 不对称合成方法学（有机催化/手性路易斯酸催化）
药物化学，生物活性化合物的合成研究
不对称催化是化学学科以及药物化学领域的前沿和研究热点，是获得光学活性化合物最高效的途径。王震博士长期从事有机合成和不对称催化工作，在手性金属配合物催化（主要是镧系路易斯酸金属催化，博士期间）以及有机小分子催化（手性氨基酸衍生的有机膦催化，博士后期间）等方面进行了系统的研究，取得了系列开拓性的创新成果。王震博士已在J. Am. Chem. Soc.，Angew.Chem. Int. Ed.，Chem. Commun.，Org. Lett.等国际权威刊物上发表论文多篇。
项目成果
代表性文章 一、编写书籍、章节
(2) Xiaoming Feng*,Zhen Wang, Xiaohua Liu,Chiral Lewis Acid,“Chiral Lewis Acid Rare-Earth Metal Complexes in Enantioselective Catalysis”, Springer International Publishing AG,2017, 147-192, DOI: 10.1007/3418_2017_1.

(1) Xiaoming Feng,Zhen Wang, Lili Lin,Electronic Encyclopedia of Reagents for Organic Synthesis,“1,3-Dicyclohexylcarbodiimide”, Wiley,2017, 5-9.

二、论文发表
(25)Zhen Wang, Xiaohua Liu*, Xiaoming Feng*, “Asymmetric Catalysis Enabled by ChiralN,N'-Dioxide–Nickel(II) Complexes”,Aldrichimica Acta2020,53, 3.

(24) Xin Wang, Mengxue Lu, Qin Su, Minghui Zhou, Yesu Addepalli, Weijun Yao,Zhen Wang* and Yixin Lu*,“Phosphine-catalyzed [4+2] cycloadditions of allenic ketones: Enantioselective synthesis of functionalized tetrahydropyridines”,Chem. Asian J.2019,14, 3409-3413.

(23)Zhen Wang*, Yesu Addepalli, and Yun He*, “Construction of Polycyclic Indole Derivatives via Multiple Aryne Reactions with Azaheptafulvenes”,Org. Lett.2018,20, 644.

(22) Yesu Addepalli, Xiaohong Yang, Minghui Zhou, D. Prabhakar Reddy, Shao-Lin Zhang,Zhen Wang*and Yun He*, “Synthesis and anticancer activity evaluation of novel azacalix[2]arene[2]pyrimidines”,Eur. J. Med. Chem.2018,151, 214.

(21) Minghui Zhou, Qin Su, Yesu Addepalli, Yun He* andZhen Wang*, “An asymmetric Mannich reaction of α-diazocarbonyl compounds and N-sulfonyl cyclic ketimines catalyzed by complexes generated from chiral and achiral phosphines with gold(I)”,Org. Biomol. Chem.2018,16, 2923.

(20) Yesu Addepalli, Zhimei Yu, Jie Ji, Cheng Zou,Zhen Wang*and Yun He*, “Tandem Diels–Alder/oxidation–aromatization reactions involving 2-styrylchromones and arynes”,Org. Biomol. Chem.2018,16, 6077.

(19) Prabhakar Reddy, Ning Zhang, Zhimei Yu,Zhen Wang, Yun He*,“Total Synthesis of Kanamienamide”.J. Org. Chem.,2017,82, 11262.
(18)Zhen Wang,* Tianli Wang, Weijun Yao and Yixin Lu* “Phosphine-Catalyzed Enantioselective [4 + 2] Annulation ofo-Quinone Methides with Allene Ketones”,Org. Lett.2017,19, 4126.

(17)Zhen Wang*, Huacheng Xu, Qin Su, Ping Hu, Pan-Lin Shao, Yun He and Yixin Lu* “Enantioselective Synthesis of Tetrahydropyridines/Piperidines via Stepwise [4+2]/[2+2] Cyclizations”,Org. Lett.2017,19, 3111.

(16) I. N. Chaithanya Kiran,? R. Santhosh Reddy,? Chandraiah Lagishetti, Huacheng Xu,Zhen Wang*, Yun He* “Selective Aza Diels-Alder and Domino [4+2]/[2+2] Cycloaddition Reactions of Arynes with N-Sulfonyl Ketimines”,J. Org. Chem.2017,82, 1823.

(15)Zhen Wang, Zhenling Chen, Sha Bai, Wei Li, Xiaohua Liu, Lili. Lin and Xiaoming Feng*, "HighlyZ-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted byN,N’-Dioxide–Metal Complexes"Angew. Chem. Int. Ed.2012, 51,2776.

(14)Zhen Wang, Zhigang Yang, Donghui Chen, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral Metal/N,N’-Dioxide Complexes: Metal-Directed Switch in Enantioselectivity”,Angew. Chem. Int. Ed.2011,50, 4928.

(13)Zhen Wang, Tengfei Kang, Qian Yao, Jie Ji, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, "Scandium-Catalyzed Asymmetric 1,6-Addition of 3-Substituted Oxindoles to Linear Dienyl Ketones"Chem. Eur. J.2015, 21, 7709.

(12)Zhen Wang, Zuliang Zhang, Qian Yao, Xiaohua Liu, Yunfei Cai, Lili Lin and Xiaoming Feng*, "Highly Stereoselective Conjugate Addition and α-Alkynylation Reaction with Electron-Deficient Alkynes Catalyzed by Chiral Scandium(III) Complexes"Chem. Eur. J.2013, 19,8591.

(11)Zhen Wang, Qian Yao, Tengfei Kang, Juhua Feng, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, "Highly Diastereo- and Enantioselective Michael Addition of 3-Substituted Benzofuran-2(3H)-ones to 4-Oxo-enoates Catalyzed by Lanthanide(III) Complexes"Chem. Comm.,2014,50, 4918.

(10)Zhen Wang, Donghui Chen, Zhigang Yang, Sha Bai, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Highly Enantioselective Synthesis of α-Stereogenic Esters through Catalytic Asymmetric Michael Addition of 4-Oxo-4-arylbutenoates"Chem. Eur. J.2010,16, 10130.

(9) Tengfei Kang,Zhen Wang, Lili Lin, Yuting Liao, Yuhang Zhou, Xiaohua Liu, and Xiaoming Feng* “N,N’-Dioxide/Zinc Bis(trifluoromethylsulfonyl)imide Complex Catalyzed Enantioselective Diels–Alder Reaction of Cyclopentadiene with Alkynones”,Adv. Synth. Catal.2015,357, 2045.

(8) Qian Yao,Zhen Wang, Yuheng Zhang, Xiaohua Liu, Lili Li, and Xiaoming Feng*, “N,N’-Dioxide/Gadolinium(III)-Catalyzed Asymmetric Conjugate Addition of Nitroalkanes to α,β-Unsaturated Pyrazolamides”,J. Org. Chem.,2015,80, 5704.

(7) Sha Bai, Xiaohua Liu,Zhen Wang, Weidi Cao, Lili Lin and Xiaoming Feng*. "Catalytic Asymmetric Friedel–Crafts Reaction of Activated Phenols and 4-Oxo-4-arylbutenoates"Adv. Synth. Catal.2012,354, 2096–2100.

(6) Zhigang Yang,Zhen Wang, Sha Bai, Xiaohua Liu, Lili Lin and Xiaoming Feng*. "Asymmetric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)₃/N,N’-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives"Org. Lett.,2011,13, 596-599.

(5) Donghui Chen,Zhen Wang, Jiangting Li, Zhigang Yang, Lili Lin, Xiaohua Liu and Xiaoming Feng*. "Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Nitrones to Alkylidene Malonates: Highly Enantioselective Synthesis of Multisubstituted Isoxazolidines"Chem. Eur. J.2011,17, 5226 – 5229.

(4) Zhigang Yang,Zhen Wang, Sha Bai, Ke Shen, Donghui Chen, Xiaohua Liu, Lili Lin and Xiaoming Feng*. "Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex"Chem. Eur. J.2010,16, 6632 – 6637.

(3) Jie Liu, Zhigang Yang, Xiaohua Liu,Zhen Wang, Yanling Liu, Sha Bai, Lili Lin and Xiaoming Feng*. "Organocatalyzed highly stereoselective Michael addition of ketones to alkylidene malonates and nitroolefins using chiral primary-secondary diamine catalysts based on bispidine"Org. Biomol. Chem.,2009,7, 4120–4127.

(2) Zhigang Yang, Jie Liu, Xiaohua Liu,Zhen Wang, Xiaoming Feng*, Zhishan Su and Changwei Hu*. "Highly Efficient Amine Organocatalysts Based on Bispidine for the Asymmetric Michael Addition of Ketones to Nitroolefins"Adv. Synth. Catal.2008,350, 2001 – 2006.

(1) Jie Liu,Zhigang Yang,Zhen Wang, Fei Wang, Xiaohong Chen, Xiaohua Liu, Xiaoming Feng*, Zhishan Su and Changwei Hu*. "Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine"J. Am. Chem. Soc.2008,130, 5654–5655.