组长：夏桂先 博士 研究员 博士生导师
研究方向
植物重要农艺性状相关基因的功能研究及应用
研究内容和意义
1. 植物与病原菌相互作用机制
大丽轮枝菌是侵染植物维管束系统的土传真菌，由其导致的棉花黄萎病是制约我国棉花生产的主要病害，被称为棉花的“癌症”，对黄萎病抗病机制的研究是目前棉花抗病分子育种的重要方向之一。我们课题组一方面以大丽轮枝菌-棉花为互作模式系统，利用转录组和蛋白质组学等方法分析棉花对黄萎病菌的免疫应答反应，选择重要基因深入进行功能和作用机制研究；另一方面，以大丽轮枝菌-拟南芥为互作体系，利用细胞自噬突变体进行比较蛋白质组学和细胞学分析，探讨植物细胞自噬参与抵御黄萎病菌侵染的作用机制。
2．棉花纤维发育的调控机制研究
棉花是世界上最重要的天然纤维作物。棉花纤维的发育包括起始期、伸长期、次生壁合成期和成熟期四个阶段。分离鉴定棉纤维发育相关基因，分析其在棉花发育不同阶段的功能和调控，是了解棉纤维发育机理，进而利用分子育种方法改良棉花纤维品质的重要环节。我们利用转录组学和蛋白质组学方法，分析了棉纤维发育相关基因/蛋白及调控途径，并在此基础上对纤维优势表达的转录因子、细胞骨架等蛋白的功能及作用机理进行深入解析，以期为纤维品质改良的分子育种提供目标基因。
3.马铃薯化肥农药减施增效技术的研发
针对我国马铃薯化肥农药高效利用及替代技术缺少导致的高施低效、流失严重和面源污染等共性关键问题，研发了具有自主知识产权的环保肥料增效助剂、功能性菌剂等专利技术，正在逐步实现产业化。通过技术集成，形成了马铃薯化肥农药减施增效技术模式，在黑龙江、甘肃、宁夏、内蒙等北方马铃薯产区进行示范推广。
组长介绍
课题组长：夏桂先，博士、研究员
电话：
电子邮件：xiagx#im.ac.cn
通讯地址：北京市朝阳区北辰西路1号院3号，
中国科学院微生物研究所
邮编：100101
学习经历
1973－76 武汉师范学院生物系
1989－90 瑞士日内瓦大学分子生物学系，硕士
1991－93 瑞士日内瓦大学分子生物学系，博士
工作经历
1976-89 湖北大学生物系
1997- 中科院微生物研究所研究员 博士生导师
研究队伍（请将#换成@）
工作人员
仲乃琴 女 正高级工程师 nqzhong#im.ac.cn
吴家和男研究员wujiahe#im.ac.cn
王海云 女 副研究员 wanghy#im.ac.cn
王付欣 女 副研究员 wangfx#im.ac.cn
赵 盼 男 高级工程师 zhaop#im.ac.cn
在读研究生博士后
类别 姓名 性别 邮箱
硕士生李文博女2016年liwenbo16#mails.ucas.ac.cn
硕士生仲萌萌女2017年zhongmmsd#163.com
已毕业研究生已毕业/离室客座成员
类别 姓名 毕业年份吴 玮 (1998-2000) 客座博士研究生 中国农业大学
硕士王 栋2001年孙 杰 (2000-2002) 客座教授 石河子大学
硕士罗 倩2014年唐亚雄 (2000-2002) 客座博士研究生 四川大学
硕士孙永铎2016年欧阳浩淼 (2002-2004) 客座硕士研究生 首都师范大学
硕士王文燕2017年李丽娟 (2003-2004) 客座硕士研究生 首都师范大学
博士李利红2002年李艳军 (2003-2005) 客座硕士研究生 石河子大学
博士李园莉2004年刘丽娜 (2003-2005) 客座硕士研究生 首都师范大学
博士曲占良2006年黄全生 (2006-2009) 客座博士研究生 新疆农科院
博士虞 沂2007年梁 杉 (2007-2009) 客座硕士研究生 河北大学
博士刘 宁2007年马银平 (2010-2012) 客座硕士研究生 山东农业大学
博士陈安平2007年
博士高 鹏2008年
博士王昉2008年
博士赵丕明2010年
博士王 娟2010年
博士武晓敏2012年
博士韩利波2014年
博士王丽丽2014年
博士杨淳淋2015年
博士李元宝2016年
博士程焕庆2016年
博士张 敏2017年
博士周心童2018年
代表性性论文
Han LB#, Li YB#, Wang FX, Wang WY, Liu J, Wu JH, Zhong NQ, Wu SJ, Jiao GL, Wang HY,* and Xia GX* (2019) The cotton apoplastic protein CRR1 stabilizes chitinase 28 to facilitate defense against the fungal pathogen Verticillium dahliae. Plant Cell 2019 Jan 16 (Online).
Wang FX*, Luo YM, Ye ZQ, Cao X, Liang JN, Wang Q, Wu Y, Wu JH, Wang HY, Zhang M, Cheng HQ, and Xia GX* (2018) iTRAQ-based proteomics analysisofautophagy-mediated immune responses against the vascular fungal pathogen Verticillium dahliae in Arabidopsis. Autophagy 14:598-618.
Zhou XT, Wang F, Ma YP, Jia LJ, Liu N, Wang HY, Zhao P, Xia GX*, and Zhong NQ* (2018) Ectopic expression of SsPETE2, a plastocyanin from Suaeda salsa, improves plant tolerance to oxidative stress. Plant Sci 268:1-10.
Zhou LL#, Zhao P#, Chi Y, Wang DF, Wang P, Liu N, Cai DQ, Wu ZY*, and Zhong NQ*. (2017) Controlling the hydrolysis and loss of nitrogen fertilizer (urea) by using a nanocomposite favors plant growth. ChemSusChem. 10:2068-2079.
Zhang M, Han LB, Wang WY, Wu SJ, Jiao GL, Su L, Xia GX*, and Wang HY* (2017) Overexpression of GhFIM2 propels cotton fiber development by enhancing actin bundle formation. J Integr Plant Biol. 59:531-534.
Wang WY, Sun YD, Han LB, Su L, Xia GX*, and Wang HY* (2017) Overexpression of GhPFN2 enhances protection against Verticillium dahliae invasion in cotton. Sci China Life Sci 60:861-867.
Zhang M, Cheng ST, Wang HY, Wu JH, Luo YM, Wang Q, Wang FX*, and Xia GX* (2016) iTRAQ-based proteomic analysis of defence responses triggered by the necrotrophic pathogen Rhizoctonia solani in cotton. J Proteomics. 152: 226-235.
Li YB#, Han LB#, Wang HY, Zhang J, Sun ST, Feng DQ, Yang CL, Sun YD, Zhong NQ*, and Xia GX* (2016) The thioredoxin GbNRX1 plays a crucial role in homeostasis of apoplastic reactive oxygen species in response to Verticillium dahliae infection in cotton. Plant Physiol 170:2392-2406.
Cheng HQ, Han LB, Yang CL, Wu XM, Zhong NQ, Wu JH, Wang FX, Wang HY*, and Xia GX* (2016) The cotton MYB108 forms a positive feedback regulation loop with CML11 and participates in the defense response against Verticillium dahliae infection. J Exp Bot 67:1935-1950.
Zhang GL, Zhu Y, Fu WD, Wang P, Zhang RH, Zhang YL, Song Z, Xia GX, and Wu JH*. (2016) iTRAQ protein profile differential analysis of dormant and germinated grassbur twin seeds reveals that ribosomal synthesis and carbohydrate metabolism promote germination possibly through the PI3K pathway. Plant Cell Physiol 57:1244-1256.
Yang CL, Liang S, Wang HY, Han LB, Wang FX, Cheng HQ, Wu XM, Qu ZL, Wu JH*, and Xia GX* (2015) Cotton major latex protein 28 functions as a positive regulator of the ethylene responsive factor 6 in defense against Verticillium dahliae. Mol Plant 8:399-411.
Zhu Y, Wang H, Peng Q, Tang Y, Xia G, Wu J*, and Xie DY*. (2015) Functional characterization of an anthocyanidin reductase gene from the fibers of upland cotton (Gossypium hirsutum). Planta 241:1075-1089.
Wang LL, Chen AP, Zhong NQ, Liu N, Wu XM, Wang F, Yang CL, Romero MF, and Xia GX* (2014) The Thellungiella salsuginea tonoplast aquaporin TsTIP1;2 functions in multiple abiotic stress protection. Plant Cell Physiol 55:148-161.
Wu JH*, Zhu C, Pang J, Zhang X, Yang C, Xia G, Tian Y, and He C* (2014) OsLOL1, a C2C2-type zinc finger protein, interacts with OsbZIP58 to promote seed germination through the modulation of gibberellin biosynthesis in Oryza sativa. Plant J 80:1118-1130.
Han LB#, Li YB#, Wang HY, Wu XM, Li CL, Luo M, Wu SJ, Kong ZS, Pei Y, Jiao GL, and Xia GX * (2013) The dual functions of WLIM1a in cell elongation and secondary wall formation in developing cotton fibers. Plant Cell 25:4421-4438.
Wang MY#, Zhao PM#, Cheng HQ, Han LB, Wu XM, Gao P, Wang HY, Yang CL, Zhong NQ, Zuo JR, and Xia GX* (2013) The cotton transcription factor GhTCP14 functions in auxin-mediated epidermal cell differentiation and elongation. Plant Physiol 162:1669-1680.
Wu XM, Yu Y, Han LB, Li CL, Wang HY, Zhong NQ, Yao Y, and Xia GX* (2012) The tobacco BLADE-ON-PETIOLE 2 gene mediates differentiation of the corolla abscission zone by controlling longitudinal cell expansion. Plant Physiol 159:835-850.
Wang F#*, Yang CL#, Wang LL#, Zhong NQ, Wu XM, Han LB, and Xia GX* (2012) Heterologous expression of a chloroplast outer envelope protein from Suaeda salsa confers oxidative stress tolerance and induces chloroplast aggregation in transgenic Arabidopsis plants. Plant Cell Environ 35:588-600.
Zhong NQ, Han LB, Wu XM, Wang LL, Wang F, Ma YH*, and Xia GX* (2012) Ectopic expression of a bacterium NhaD-type Na+/H+ antiporter leads to increased tolerance to combined salt/alkali stresses. J Integr Plant Biol 54:412-421. (cover story).
Wang FX, Ma YP, Yang CL, Zhao PM, Yao Y, Jian GL, Luo YM*, and Xia GX* (2011) Proteomic analysis of the sea-island cotton roots infected by wilt pathogen Verticillium dahliae. Proteomics 11:4296-4309.
Wang J, Wang HY, Zhao PM, Han LB, Jiao GL, Zheng YY, Huang SJ, and Xia GX* (2010) Overexpression of a profilin (GhPFN2) promotes the progression of developmental phases in cotton fibers. Plant Cell Physiol 51:1276-1290.
Zhao PM, Wang LL, Han LB, Wang J, Yao Y, Wang HY, Du XM, Luo YM*, and Xia GX* (2010) Proteomic identification of differentially expressed proteins in the Ligon lintless mutant of upland cotton (Gossypium hirsutum L.). J Proteome Res 9:1076-1087.
Wang HY#, Wang J#, Gao P, Jiao GL, Zhao PM, Li Y, Wang GL, and Xia GX* (2009) Down-regulation of GhADF1 gene expression affects cotton fibre properties. Plant Biotechnol J 7:13-23.
Wang F, Zhong NQ, Gao P, Wang GL, Wang HY, and Xia GX* (2008) SsTypA1, a chloroplast-specific TypA/BipA-type GTPase from the halophytic plant Suaeda salsa, plays a role in oxidative stress tolerance. Plant Cell Environ 31:982-994.
Huang QS, Wang HY, Gao P, Wang GY, and Xia GX* (2008) Cloning and characterization of a calcium dependent protein kinase gene associated with cotton fiber development. Plant Cell Rep. 27:1869-75.
Gao P, Zhao PM, Wang J, Wang HY, Du XM, Wang GL, and Xia GX* (2008) Co-expression and preferential interaction between two calcineurin B-like proteins and a CBL-interacting protein kinase from cotton. Plant Physiol Biochem. 46:935-40.
Liu N, Zhong NQ, Wang GL, Li LJ, Liu XL, He YK, and Xia GX* (2007) Cloning and functional characterization of PpDBF1 gene encoding a DRE-binding transcription factor from Physcomitrella patens. Planta 226:827-38.
Chen AP, Zhong NQ, Qu ZL, Wang F, Liu N and Xia GX* (2007) Root and vascular tissue-specific expression of glycine-rich protein AtGRP9 and its interaction with AtCAD5, a cinnamyl alcohol dehydrogenase, in Arabidopsis thaliana. J Plant Res 120:337-43.
Yu Y, Wang HY, Liu LN, Chen ZL, and Xia GX* (2007) Functional identification of cytokinesis-related genes from tobacco BY-2 cells. Plant Cell Rep 26:889-94.
Chen AP, Wang GL, Qu ZL, Lu CX, Liu N, Wang F, and Xia GX* (2007) Ectopic expression of ThCYP1, a stress-responsive cyclophilin gene from Thellungiella halophila, confers salt tolerance in fission yeast and tobacco cells. Plant Cell Rep. 26:237-45.
Qu ZL, Zhong NQ, Wang HY, Chen AP, Jian GL, and Xia GX* (2006) Ectopic expression of the cotton non-symbiotic hemoglobin gene GhHbd1 triggers defense responses and increases disease tolerance in Arabidopsis. Plant Cell Physiol. 47:1058-68.
Qu ZL, Wang HY, and Xia GX* (2005) GhHb1: a nonsymbiotic hemoglobin gene of cotton responsive to infection by Verticillium dahliae. Biochim Biophys Acta. 15:103-13.
Wang HY, Yu Y, Chen ZL, and Xia GX* (2005) Functional characterization of Gossypium hirsutum profilin 1 gene (GhPFN1) in tobacco suspension cells. Planta. 222:594-603.
Li YL, Sun J, and Xia GX* (2005) Cloning and characterization of a gene for an LRR receptor-like protein kinase associated with cotton fiber development. Mol Genet Genomics. 273:217-24.
