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摘要热籽介导肿瘤磁感应热疗前,为确定有效治疗区域及防止正常组织热损伤,需要建立三维治疗模型,进行温度分布的数值计算。该文采用毫米级的铁磁热籽作为植入材料,对其升温和传热过程进行空间数学模型建立,使用有限体积法对生物传热方程进行求解,研究不同热籽排布状态下的三维温度稳态分布情况,且在此基础上针对不同血液灌注率下磁感应热疗的组织温度分布和有效热疗区域进行了分析。研究表明: 不同热籽排布对治疗温度分布影响较大,选用合适的热籽排布方案可以保证磁感应热疗良好的适形性; 此外,血液灌注率较大的生物组织会显著降低治疗温度分布,在术前计划制定时应当综合考虑。该文结果对于制定合理的磁感应热疗术前计划、预测靶区热籽空间排布和有效治疗区域具有一定参考意义。
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| 关键词 ：铁磁热籽,磁感应热疗,稳态温度分布,有限体积方法,三维仿真 |
Abstract：Before tumor thermoseed mediated magnetic induction hyperthermia can be used, in vivo 3-D treatment models and temperature distributions in the target region should be numerically simulated to ensure the curative efficacy and to prevent overheating of normal tissues. This paper uses Ni-Cu alloy thermoseeds as the implanted medium in a heating model using the Pennes equation discretized by the finite volume method to study the steady-state temperature distributions for different thermoseed arrangements. The model predicts the temperature fluctuation and effective treatment areas for different blood perfusions. These results show that the preoperative thermoseed arrangement planning and the bio-tissue blood perfusion rate are both key factors to determine the steady-state temperature distributions. This paper provides guidelines for reasonable preoperative treatment planning for magnetic induction hyperthermia.
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| Key words：ferromagnetic thermoseedmagnetic induction hyperthermiasteady-state temperature distributionsfinite volume method3-D simulations |
| 收稿日期: 2013-07-15 出版日期: 2015-09-03 |
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| 基金资助:国家 “十二五” 科技支撑计划资助项目 (2012BAI15B04);北京市科技计划资助项目 (Z111100067311053) |
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