制药废水中抗生素的去除技术研究进展

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Research progress of removal technology of antibiotics from antibiotic production wastewater

ZHANG Yu^1,2,3,,
TANG Mei^1,2,3,
TIAN Zhe^1,2,3,
GAO Yingxin^1,2,3,
YANG Min^1,2,3
1.National Engineering Laboratory for Industrial Wastewater Treatment, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
2.State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
3.University of Chinese Academy of Sciences, Beijing 100049, China

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摘要:发酵类抗生素生产废水中残留抗生素及相关物质(残留效价)含量高,对废水生物处理系统微生物群落结构以及废水处理效果影响显著,同时会导致生物处理细菌耐药基因的产生和排放；因此,如何去除废水中残留抗生素及效价是解决抗生素废水处理难题的关键。在前期研究的基础上,提出高浓度抗生素生产废水残留抗生素效价的水处理控制目标,概述了水中抗生素去除的生物和物化技术的最新研究进展,提出了在废水生物处理之前进行抗生素选择性去除的强化催化水解预处理技术方案,结合生物处理之后采用高级氧化技术保障该类废水安全排放,并对未来该类废水处理技术的发展方向提出了建议,以期为行业的可持续发展提供技术支持和科学依据。
关键词: 抗生素生产废水/
抗生素效价/
强化催化水解/
废水处理/
耐药基因

Abstract:The concentration of residual antibiotics and related substances (residual antibacterial potency) in the fermentative antibiotic production wastewater is high, which has a significant impact on the microbial community structure of the biological wastewater treatment systems and leads to the generation of antibiotic resistance genes (ARGs). Therefore, selective removal of residual antibiotics and related substances (residual antibacterial potency) in wastewater is the key to solve the problem of antibiotic production wastewater. Based on the previous work, this paper suggested the control target of the antibiotic production wastewater treatment, summarized the latest research progress on the biological and physicochemical technology of antibiotic removal from water, proposed enhanced hydrolysis pretreatment technology before biological wastewater treatment for the selective antibiotic removal, and provide the suggestion for future development directions of treatment of such wastewater.
Key words:antibiotic production wastewater/
antibacterial potency/
enhanced catalytic hydrolysis/
wastewater treatment/
resistance genes.

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