季倩倩,
王瀚,
吴添舒,
环境医学工程教育部重点实验室, 东南大学公共卫生学院, 南京 210009
作者简介: 程锦(1999-),女,学士,研究方向为预防医学,E-mail:1123208027@qq.com.
通讯作者: 吴添舒,ninatswu@seu.edu.cn
基金项目: 江苏省基础研究计划资助项目（BK20180371）；中央高校基本科研业务费专项资金资助项目（2242020K40192）；东南大学至善青年****项目（2242020R40140）；国家级创新训练项目（201910286148）中图分类号: X171.5
Research Advance on the Toxic Effects of Quantum Dots in Nematodes Caenorhabditis elegans and the Regulated Mechanisms
Cheng Jin,Ji Qianqian,
Wang Han,
Wu Tianshu,
Ministry of Education Key Laboratory of Environmental Medicine Engineering, School of Public Health, Southeast University, Nanjing 210009, China
Corresponding author: Wu Tianshu,ninatswu@seu.edu.cn
CLC number: X171.5
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摘要:量子点（quantum dots，QD）作为一种纳米微晶体，由于其出色的光学特性，已经被广泛应用于电子、生物医学成像、生物传感器和药物递送中，因而量子点的生物安全性也变得至关重要。秀丽隐杆线虫作为一种简单的生物模型，生物学基础完善、生命周期短、繁殖量大、生活特征易获得，不仅可以提供全动物水平的生理相关数据，还允许在单细胞水平上进行分析，是量子点毒性试验的良好生物模型。本文总结了量子点对秀丽隐杆线虫毒性研究的进展，重点阐述了量子点导致线虫四大系统的毒性效应及其可能的毒作用机制，同时展望了今后秀丽隐杆线虫在量子点毒性研究甚至纳米毒性研究领域的广阔前景。
关键词: 量子点/
秀丽隐杆线虫/
毒性效应
Abstract:Quantum dots (QDs), as a type of nanocrystal nanomaterial, have been widely used in fields of electronic, biomedical imaging, biosensor and drug delivery because of their excellent optical properties. Therefore, it is important to assess the biological safety of QDs. As a simple biological model, nematodes Caenorhabditis elegans (C. elegans) have multiple advantages, including short life cycle, large reproduction and easy accessing to life characteristics, which could provide physiological data not only at the whole animal level but also at the single cell level. So far, nematodes C. elegans have been considered as a good biological model in the toxicological study of nanomaterials, including QDs. This review focused on multiple damages caused by QDs on four biological systems of C. elegans and the underlying toxic mechanisms through summarizing and analyzing the toxic effects of QDs on C. eleagans according to available studies. The bright perspectives of using C. elegans in the toxicity study of QDs and other nanomaterials in the future were demonstrated as well.
Key words:quantum dots/
Caenorhabditis elegans/
toxic effects.
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