任文娟^1,2,
汪贞¹,
王蕾¹,
杨先海¹,
刘济宁¹
1. 环境保护部南京环境科学研究所, 南京 210042;
2. 南京工业大学 生物与制药工程学院, 南京 211816

作者简介: 任文娟(1989-),女,硕士,研究方向为生态毒理学,E-mail:rwj123123@126.com.

基金项目: 江苏省自然科学基金资助项目(No.BK20151100)


中图分类号: X171.5

Effects of Bisphenol A and Its Analogues on Zebrafish Embryos and Larvae

Ren Wenjuan^1,2,
Wang Zhen¹,
Wang Lei¹,
Yang Xianhai¹,
Liu Jining¹
1. Nanjing Institute of Environmental Sciences, Ministry of Environmental Protection, Nanjing 210042, China;
2. School of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China

CLC number: X171.5

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摘要:为探讨双酚A及其类似物对鱼类早期生长发育的毒性效应，研究了双酚A及其7种类似物对斑马鱼胚胎及仔鱼的毒性效应。通过对胚胎的孵化率、心率、仔鱼体长等指标进行测定分析，结果显示：(1)双酚A及其7种类似物都可使斑马鱼胚胎出现心包水肿、卵黄囊肿、脊柱弯曲和尾部弯曲等症状。(2)综合考虑斑马鱼78 hpf胚胎心率、120 hpf胚胎孵化率及7 dpf仔鱼体长抑制率等指标，8种受试物中双酚P(BPP)的毒性最大，其次是双酚AP(BPAP)、双酚AF(BPAF)、双酚Z(BPZ)，然后是双酚A(BPA)、双酚B(BPB)、双酚F(BPF)，双酚S(BPS)的毒性最小，每种受试物的浓度与受精卵的孵化率、仔鱼心率呈明显负相关关系，与体长抑制率呈明显正相关关系。8种受试物毒性与辛醇-水分配系数(log K_OW)呈正相关关系，logK_OW越大毒性则越大。
关键词: 双酚A/
双酚A类似物/
斑马鱼/
胚胎/
仔鱼/
毒性

Abstract:We evaluated the toxic effect of bisphenol A (BPA) and its seven analogues on zebrafish embryos and larvae. Based on the results of the hatching rate (120 hpf), heart rate (78 hpf), body length of larvae (7 dpf), it is indicated that: (1) BPA and its analogues caused cardiac edema, cyst vitelline, spinal curvature and tail bending; (2) the order of the toxicity is bisphenol P (BPP)> bisphenol AP (BPAP)> bisphenol AF (BPAF)> bisphenol Z (BPZ)> bisphenol A (BPA)> bisphenol B (BPB)> bisphenol F (BPF)> bisphenol S (BPS). The concentrations of the test substances were negatively correlated with the embryo hatching rate and the heart rate of larvae, while positive correlation with inhibition rate of larval length. In addition, the toxicity of these eight kinds of BPA analogues and the values of octanol-water partition (logK_OW) were positively correlated.
Key words:bisphenol A/
bisphenol A analogues/
zebrafish/
embryo/
larvae/
toxicity.