) 安徽医科大学医学心理学系, 合肥 230000
收稿日期:2017-05-29出版日期:2018-06-01发布日期:2018-04-28通讯作者:汪凯E-mail:wangkai1964@126.com基金资助:省高校自然科学研究重点项目(KJ2016A355);安徽医科大学博士科研基金(XJ201521);国家自然科学基金面上项目(31771222);国家自然科学基金面上项目(31571149);国家自然科学基金面上项目(81771456);基金委重大研究计划集成项目资助(91432301)Excitation of the right dorsolateral prefrontal cortex with transcranial direct current stimulation influences response inhibition
WANG Hui Hui, LUO Yu Dan, SHI Bing, YU Feng Qiong, WANG Kai() Department of Medical Psychology, Anhui Medical University, Hefei 230000, China
Received:2017-05-29Online:2018-06-01Published:2018-04-28Contact:WANG Kai E-mail:wangkai1964@126.com摘要/Abstract
摘要： 拟观察经颅直流电刺激作用于右侧背外侧前额叶皮层前后, 被试在停止信号任务中的行为变化。实验共入组34名正常大学生, 被试前后两次随机接受真刺激和伪刺激, 两次刺激间隔7天, 每个被试在接受刺激前后均完成停止信号任务, 并在每次实验前后完成Stroop色词任务、词语流畅性、数字广度任务。结果发现真刺激作用于右侧背外侧前额叶皮层后停止信号反应时显著减小, 但伪刺激条件下没有该趋势。本实验证明了作用于右侧背外侧前额叶皮层的经颅直流电刺激可以调节反应抑制能力, 右侧背外侧前额叶皮层是反应抑制的重要脑区。
图/表 7
图1电极片放置位置
图1电极片放置位置
图2停止信号任务流程图注：彩图见电子版
图2停止信号任务流程图注：彩图见电子版表1真伪刺激前后神经心理学测验结果比较
| 组别 | M ± SD | t值 | p值 |
|---|---|---|---|
| 真刺激前stroop效应量 | 6.79 ± 4.58 | 0.49 | 0.628 |
| 伪刺激前stroop效应量 | 7.32 ± 4.67 | ||
| 真刺激前后stroop效应量 | -0.99 ± 4.52 | -1.28 | 0.209 |
| 伪刺激前后stroop效应量 | -1.36 ± 4.09 | -1.93 | 0.062 |
| 真刺激前数字广度(顺背) | 7.94 ± 0.24 | 1.44 | 0.160 |
| 伪刺激前数字广度(顺背) | 8.00 ± 0.00 | ||
| 真刺激前后数字广度(顺背) | 0.03 ± 1.17 | 1.00 | 0.325 |
| 伪刺激前后数字广度(顺背) | 0.00 ± 0.00 | ||
| 真刺激前数字广度(倒背) | 6.06 ± 0.95 | -0.73 | 0.473 |
| 伪刺激前数字广度(倒背) | 5.94 ± 0.95 | ||
| 真刺激前后数字广度(倒背) | 0.21 ± 0.54 | 2.23 | 0.033 |
| 伪刺激前后数字广度(倒背) | 0.44 ± 0.70 | 3.65 | 0.001 |
| 真刺激前词语流畅性 | 27.26 ± 5.46 | -0.49 | 0.625 |
| 伪刺激前词语流畅性 | 26.79 ± 4.93 | ||
| 真刺激前后词语流畅性 | 3.38 ± 4.06 | 4.86 | 0.000 |
| 伪刺激前后词语流畅性 | 4.47 ± 4.53 | 5.75 | 0.000 |
表1真伪刺激前后神经心理学测验结果比较
| 组别 | M ± SD | t值 | p值 |
|---|---|---|---|
| 真刺激前stroop效应量 | 6.79 ± 4.58 | 0.49 | 0.628 |
| 伪刺激前stroop效应量 | 7.32 ± 4.67 | ||
| 真刺激前后stroop效应量 | -0.99 ± 4.52 | -1.28 | 0.209 |
| 伪刺激前后stroop效应量 | -1.36 ± 4.09 | -1.93 | 0.062 |
| 真刺激前数字广度(顺背) | 7.94 ± 0.24 | 1.44 | 0.160 |
| 伪刺激前数字广度(顺背) | 8.00 ± 0.00 | ||
| 真刺激前后数字广度(顺背) | 0.03 ± 1.17 | 1.00 | 0.325 |
| 伪刺激前后数字广度(顺背) | 0.00 ± 0.00 | ||
| 真刺激前数字广度(倒背) | 6.06 ± 0.95 | -0.73 | 0.473 |
| 伪刺激前数字广度(倒背) | 5.94 ± 0.95 | ||
| 真刺激前后数字广度(倒背) | 0.21 ± 0.54 | 2.23 | 0.033 |
| 伪刺激前后数字广度(倒背) | 0.44 ± 0.70 | 3.65 | 0.001 |
| 真刺激前词语流畅性 | 27.26 ± 5.46 | -0.49 | 0.625 |
| 伪刺激前词语流畅性 | 26.79 ± 4.93 | ||
| 真刺激前后词语流畅性 | 3.38 ± 4.06 | 4.86 | 0.000 |
| 伪刺激前后词语流畅性 | 4.47 ± 4.53 | 5.75 | 0.000 |
表2刺激前后SSRT差异比较
| 组别 | M ± SD | t值 | p值 |
|---|---|---|---|
| 真刺激前SSRT | 306.70 ± 44.78 | -2.25 | 0.031 |
| 真刺激后SSRT | 290.82 ± 40.97 | ||
| 伪刺激前SSRT | 291.57 ± 33.21 | 1.99 | 0.055 |
| 伪刺激后SSRT | 302.13 ± 40.50 |
表2刺激前后SSRT差异比较
| 组别 | M ± SD | t值 | p值 |
|---|---|---|---|
| 真刺激前SSRT | 306.70 ± 44.78 | -2.25 | 0.031 |
| 真刺激后SSRT | 290.82 ± 40.97 | ||
| 伪刺激前SSRT | 291.57 ± 33.21 | 1.99 | 0.055 |
| 伪刺激后SSRT | 302.13 ± 40.50 |
图3刺激前后SSRT值
图3刺激前后SSRT值
图4真刺激和伪刺激前后SSRT值
图4真刺激和伪刺激前后SSRT值
图5真刺激前后男女SSRT值
图5真刺激前后男女SSRT值参考文献 33
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