李云海
职称：研究员

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研究方向：植物分子和发育生物学


李云海，博士，研究员，博士生导师
1996年河南大学学士，1999年中国农业科学院（中国水稻研究所）硕士，2003年中国科学院遗传与发育生物学研究所博士。2003-2008年英国John Innes Centre博士后。2008年9月任中国科学院遗传与发育生物学研究所研究员，博士生导师； 2015年“国家****基金”获得者; 2016年入选科技部“中青年科技创新领军人才”；2017年获得第三批国家“****”领军人才。

研究方向:植物种子和器官大小调控的分子机理研究
植物是如何感知并决定其种子和器官大小是一个重要的发育生物学问题。同时，植物种子和器官大小也是重要的产量性状。主要以水稻和拟南芥等为材料，建立植物种子与器官大小调控的分子遗传网络,解析外界环境和内源信号调控种子和器官生长的分子机制，并应用研究成果开展作物分子设计育种。

植物种子大小调控的分子遗传网络(Li et al., Annual Review of Plant Biology 2019)

研究组工作人员：段朋根（副研究员）、张保兰（工程师）、张丽敏（助理研究员）、郝建琴（特别研究助理）、刘亚陪（特别研究助理）
研究生：刘祖培、黄洛将、江珊、黄科、严莉、李英杰、张国政、于海跃、焦文杰、张浩、崔桂彩
客座研究生：吴伦英、李静
特别研究助理/博士后和客座研究生招聘信息：
本实验室目前计划招生特别研究助理/博士后2名和客座研究生2名，欢迎对植物种子和器官大小调控研究感兴趣的有志青年申请(yhli@genetics.ac.cn)。
近期发表的论文 （* 为通讯作者; ^#共同第一作者）：
2020
Lyu J#, Wang D#, Duan P#, Liu Y#, Huang K, Zeng D, Zhang L, Dong G, Li Y, Xu R, Zhang B, Huang X, Li N, Wang Y, Qian Q*, Li Y*. (2020) Control of Grain Size and Weight by the GSK2-LARGE1/OML4 Pathway in Rice. The Plant Cell. doi: 10.1105/tpc.19.00468.
Liu Z, Li N, Zhang Y, Li Y*. (2020) Transcriptional repression of GIF1 by the KIX-PPD-MYC repressor complex controls seed size in Arabidopsis.Nature Communications. doi: 10.1038/s41467-020-15603-3.
Li Y#, Xia T#, Gao F, Li Y*. (2020) Control of Plant Branching by the CUC2/CUC3-DA1-UBP15 Regulatory Module. The Plant Cell. doi: 10.1105/tpc.20.00012.
2019
Liu Z#, Chen G#, Gao F, Xu R, Li N, Zhang Y, and Li Y*. (2019) Transcriptional Repression of the APC/C Activator Genes CCS52A1/A2 by the Mediator Complex Subunit MED16 Controls Endoreduplication and Cell Growth in Arabidopsis. The Plant Cell. 31:1899-1912.
Li N#, Xu R#, Li Y*.(2019) Molecular networks of seed size control in plants. Annual Review of Plant Biology. 70:435-463. (Invited review)
Xu R#, Li N#, Li Y*. (2019) Control of grain size by G protein signaling in rice. J Integr Plant Biol. 61(5):533-540. (Invited review)
2018
Peng Y#, Chen L#, Li S#, Zhang Y, Xu R, Liu Z, Liu W, Kong J, Huang X, Wang Y, Cheng B, Zheng L, and Li Y*. (2018) BRI1 and BAK1 interact with G proteins and regulate sugar-responsive growth and development in Arabidopsis Nature Communications 9:1522.
Li S#,Xu R#,Li A#,Liu K,Gu L,Li M,Zhang H,Zhang Y,Zhuang S,Wang Q,Gao G,Li N,Zhang C,Li Y*,Yu B*. (2018) SMA1, a homolog of the splicing factor Prp28, has a multifaceted role in miRNA biogenesis in Arabidopsis. Nucleic Acids Research, 46(17):9148-9159.
Xu R#, Yu H#, Wang J#, Duan P#, Zhang B, Li J, Li Y, Xu J, Lyu J, Li N, Chai T, Li Y*. (2018) A Mitogen-Activated Protein Kinase Phosphatase influences grain size and weight in rice. Plant Journal, 95(6):937-946.
Xu R#, Duan P#, Yu H#, Zhou Z, Zhang B, Wang R, Li J, Zhang G, Zhuang S, Lyu J, Li N, Chai T, Tian Z,Yao S, and Li Y*. (2018) Control of grain size and weight by the OsMKKK10-OsMKK4-OsMAPK6 signaling pathway in rice. Molecular Plant, 11:860-873.
Li N#, Liu Z#, Wang Z, Ru L, Gonzalez N, Baekelandt A, Pauwels L, Goossens A, Xu R, Zu Z, Inzé D, Li Y*. (2018) STERILE APETALA modulates the stability of a repressor protein complex to control organ size in Arabidopsis thaliana. PLoS Genetics. 14(2):e**.
Li N, Xu R, Duan P, Li Y*. (2018) Control of grain size in rice.
Plant Reprod. 31:237-251. (Invited review)
Baekelandt A, Pauwels L, Wang Z, Li N, De Milde L, Natran A, Vermeersch M, Li Y, Goossens A, Inzé D, Gonzalez N. (2018) Arabidopsis Leaf Flatness Is Regulated by PPD2 and NINJA through Repression ofCYCLIN D3Genes.
Plant Physiology. 178(1):217-232.
2017
Huang K#, Wang D#, Duan P#, Zhang B, Xu R, Li N, Li Y*. (2017)
WIDE AND THICK GRAIN 1, which encodes an otubain-like protease with deubiquitination activity, influences grain size and shape in rice. Plant Journal. 91(5):849-860.
Duan P#, Xu J#, Zeng D, Zhang B, Geng M, Zhang G, Huang K, Huang L, Xu R, Ge S, Qian Q and Li Y*. (2017) Natural variation in the promoter of GSE5 contributes to grain size diversity in rice. Molecular Plant 10(5):685-694.
Dong H^#, Dumenil J^#, Lu F^#, Li N^#., Vanhaeren H, Naumann C, Klecker M, Prior R, Smith C, McKenzie N, Saalbach G, Chen C, Xia T, Gonzalez N, Seguela M, Inze D, Dissmeyer N, Li Y*, Bevan M*. (2017) Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis. Genes & Development 31(2):197-208.
Wang J, Tang M, Chen S, Zheng X, Mo H, Li S, Wang Z, Zhu K, Ding L, Liu S, Li Y*, Tan X*. (2017) Down-regulation of BnDA1, whose gene locus is associated with the seeds weight, improves the seeds weight and organ size in Brassica napus. Plant Biotechnology Journal 15:1024-1033.
2016
Li, N., Li, Y* (2016) Signaling pathways of seed size control in plants. Current Opinion in Plant Biology 33:23-32. (Invited review)
Chen L^#., Peng, Y^#., Tian, J., Wang, X, Kong, Z, Mao, T, Yuan, M, Li Y* (2016) TCS1, a microtubule-binding protein, interacts with KCBP/ZWICHEL to regulate trichome cell shape in Arabidopsis thaliana. PLoS Genetics 12(10):e**.
Xu, Y^#., Jin, W^#., Li, N., Zhang, W., Liu, C., Li, C*., Li, Y* (2016) UBIQUITIN-SPECIFIC PROTEASE 14 interacts with ULTRAVIOLET-B INSENSITIVE 4 to regulate endoreduplication and cell and organ growth in Arabidopsis. The Plant Cell 28(5):1200-1214.
Wang Z., Li N., Jiang S., Gonzalez N., Huang X., Wang Y., Inze D., Li, Y* (2016) SCF^SAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana. Nature Communications 7:11192.
Fang N, Xu R, Huang L, Zhang B, Duan P, Li N, Luo Y*, Li Y*. (2016) SMALL GRAIN 11 Controls Grain Size, Grain Number and Grain Yield in Rice. Rice 9(1):64.
Duan, P^#., Ni, S^#., Wang, J^#., Zhang, B^#., Xu, R., Wang, Y., Chen, H., Zhu, X*., and Li Y* (2016) Regulation of OsGRF4 by OsmiR396 controls grain size and yield in rice. Nature Plants 2(1). (Cover story)
2015
Zhang, Y., Du, L., Xu, R., Cui, R., Hao, J., Sun, C., and Li Y* (2015) Transcription factors SOD7/NGAL2 and DPA4/NGAL3 act redundantly to regulate seed size by directly repressing KLU expression in Arabidopsis thaliana. The Plant Cell 27(3):620-32.
Peng, Y^#., Chen, L^#., Lu, Y., Wu, Y., Dumenil, J., Zhu, Z., Bevan, M., and Li Y* (2015) The ubiquitin receptors DA1, DAR1 and DAR2 redundantly regulate endoreduplication by modulating the stability of TCP14/14 in Arabidopsis. The Plant Cell 27(3):649-62.
Liu, S., Hua, L., Dong, S., Chen, H., Zhu, X., Jiang, J., Zhang, F., Li, Y., Fang, X., and Chen F (2015) OsMAPK6, a mitogen-activated protein kinase, influences rice grain size and biomass production. Plant Journal 84(4):672-681.
Zheng, L*^#., Shang, L^#., Chen, X., Zhang, L., Xia, Y., Smith, C., Bevan, MW., Li, Y., Jing, HC. (2015) TANG1, Encoding a Symplekin_C Domain-Contained Protein, Influences Sugar Responses in Arabidopsis. Plant Physiology 168(3):1000-12.
Li, N., and Li, Y., * (2015) Maternal control of seed size in plants. Journal of Experimental Botany 66(4):1087-1097. (Invited review)
2014
Du, L^#., Li, N^#., Chen, L., Xu, Y., L, Y., Zhang, Y., Li, C., Li, Y*. (2014) The ubiquitin receptor DA1 regulates seed and organ size by modulating the stability of the ubiquitin-specific protease UBP15/SOD2 in Arabidopsis. The Plant Cell 26(2):665-677.
Li, N., Li, Y*. (2014) Ubiquitin-mediated control of seed size in plants. Frontiers in Plant Science 5:332. (Invited review)
Duan, P^#., Rao, Y^#., Zeng, D^#., Yang, Y., Xu, R., Zhang, B., Dong, G., Qian, Q.*, Li, Y*. (2014) SMALL GRAIN 1, which encodes a mitogen-activated protein kinase kinase 4 (MKK4), influences grain size in rice. The Plant Journal 77(4):547-57.
Colas des Francs-Small C, Falcon de Longevialle A, Li Y, Lowe E, Tanz S, Smith C, Bevan M, Small I. (2014) The Pentatricopeptide Repeat Proteins TANG2 and ORGANELLE TRANSCRIPT PROCESSING439 Are Involved in the Splicing of the Multipartitenad5Transcript Encoding a Subunit of Mitochondrial Complex I. Plant Physiology 165(4):1409-1416.
2013
Xia T^#., Li, N^#., Dumenil, J., Li, J., Kamenski, A., Bevan, M., Gao, F., Li, Y*. (2013) The Ubiquitin Receptor DA1 Interacts with the E3 Ubiquitin Ligase DA2 to Regulate Seed and Organ Size in Arabidopsis. The Plant Cell 25(9):3347-59.
Peng, Y^#., Ma, W^#., Chen, L., Yang, L., Li, S., Zhao, H., Zhao, Y., Jin, W., Li, N., Bevan, MW., Li, X., Tong, Y*., Li, Y*. (2013) Control of root meristem size by DA1-related protein 2 in Arabidopsis thaliana. Plant Physiology 161(3):1542-56.
Peng Y, Chen L, Lu Y, Ma W, Tong Y, Li Y*. (2013) DAR2 acts as an important node connecting cytokinin, auxin, SHY2 and PLT1/2 in root meristem size control. Plant Signal Behav. 8(6): e24226.
2012
Fang, W^#., Wang, Z^#., Cui, R., Li, J., and Li, Y*. (2012) Maternal control of seed size by EOD3/CYP78A6 in Arabidopsis thaliana. The Plant Journal 70(6):929-39.
Li, S^#., Liu, Y^#., Zheng, L., Chen, L., Li, N., Corke, F., Lu, Y., Fu, X., Zhu, Z., Bevan, M., and Li, Y*. (2012) The plant specific G protein γ subunit AGG3 influences organ size and shape in Arabidopsis thaliana. New Phytologist 194(3):690-703.
Li S, Liu W, Zhang X, Liu Y, Li N, Li, Y*. (2012) Roles of the Arabidopsis G protein γ subunit AGG3 and its rice homologs GS3 and DEP1 in seed and organ size control. Plant Signal Behav. 7(10):1357-9.
Xu, R and Li, Y*. (2012). The Mediator complex subunit 8 regulates organ size in Arabidopsis thaliana. Plant Signal Behav. 7(2):182-3.
2011
Xu, R and Li, Y*. (2011) Control of final organ size by Mediator complex subunit 25 in Arabidopsis thaliana. Development 138:4545-4554.
2010以前
Li, Y*, Zheng, L., Corke, F., Smith, C., and Bevan, M.W*. (2008) Control of seed and organ size by the DA1 gene family in Arabidopsis thaliana. Genes & Development 22:1331-1336.
Li, Y., Smith, C., Corke, F., Zheng, L., Merali, Z., Ryden, P., Derbyshire, P., Waldron, K., and Bevan, M.W*. (2007) Signaling from an altered cell wall to the nucleus mediates sugar-responsive growth and development in Arabidopsis thaliana. The Plant Cell 19: 2500-2515.
Li, Y., Lee, K.K., Walsh, S., Smith, C., Hadingham, S., Sorefan, K., Cawley, G., and Bevan, M.W*. (2006) Establishing glucose- and ABA-regulated transcription networks in Arabidopsis by microarray analysis and promoter classification using a Relevance Vector Machine. Genome Research 16: 414-427.
Rook F, Hadingham S, Li Y and Bevan MW*. (2006) Sugar and ABA response pathways and the control of gene expression. Plant Cell & Enviroment 29 (3):426-434.
Li, Y^#., Sorefan, K^#., Hemmann, G^#., and Bevan, M.W*. (2004) Arabidopsis NAP and PIR regulate actin-based cell morphogenesis and multiple developmental processes. Plant Physiology 136: 3616-3627.
Li, Y^#., Qian, Q^#., Zhou, Y^#., Yan, M., Sun, L., Zhang, M., Fu, Z., Wang, Y., Han, B., Pang, X., Chen, M., and Li, J*. (2003) BRITTLE CULM1, which encodes a COBRA-like protein, affects the mechanical properties of rice plants. The Plant Cell 15: 2020-2031.