中文关键词:Oxa-Michael加成 醇 甘油 丙烯酰胺 英文关键词:Oxa-Michael addition, Alcohol, Glycerol, Acrylamide 基金项目:

作者	单位	E-mail
刘启超	河北工业大学 化工学院	1757110170@qq.com
周宏勇	河北工业大学 化工学院
王家喜	河北工业大学 化工学院	wangjiaxi@hebut.edu.cn

摘要点击次数:1605 全文下载次数:0 中文摘要: 本文利用醇与丙烯酰胺的oxa-Michael加成，合成了一系列β-烷氧基丙酰胺类化合物。通过NMR，HRMS表征了产物的结构。考察了催化剂、反应温度、原料配比对反应的影响。在40 ℃下，5 (mol) %的活化碳酸钾能催化伯醇与丙烯酰胺发生oxa-Michael加成，仲醇的反应活性较低，叔醇及苯酚几乎不反应。温度升高及强碱会导致丙烯酰胺自身aza-Michael加成反应形成二聚体。醇与丙烯酰胺可以在等官能团比的无溶剂条件下反应。分子内的氢键有利于提高仲羟基的反应活性。 英文摘要: A series of β-alkoxypropionamides were synthesized by the oxa-Michael addition reaction of alcohol with acrylamide. The structure of product was characterized by NMR and HRMS. The effects of catalyst, reaction temperature, and ratio of reactants on the reaction were explored. At 40 ℃, the oxa-Michael addition reaction of primary alcohol with acrylamide went smoothly under promotion of 5 (mol) % activated potassium carbonate. The activity of secondary alcohol is lower. As for tertiary alcohol and phenol, almost no reaction was observed. At higher temperature, the acrylamide underwent the aza-Michael addition to generate dimer of acrylamide. The reaction of alcohol with acrylamide can be run at equivalent ratio as the solvent-free mode. Intramolecular hydrogen bond can increase the reactivity of secondary hydroxyl group. 查看全文查看/发表评论下载PDF阅读器 相关附件：辅助材料投稿说明信版权转让声明书辅助材料修改说明 -->