中文关键词:4-噻唑酮 合成 抑菌活性 英文关键词:4-thiazolidinone, Synthesis, antifungalactivity 基金项目:贵州省教育厅青年人才成长项目（黔教合KY字[2017]169）和贵州省中医药、民族医药科学技术研究专项（QZYY2017-081）

作者	单位	E-mail
於祥	贵阳中医学院药学院 贵阳 550025	yuxiangjx@126.com
陈娅芳	贵阳中医学院药学院 贵阳 550025

摘要点击次数:1181 全文下载次数:0 中文摘要: 本文以取代苯甲醛、苯胺及巯基乙酸为原料,合成了一系列2,3-二苯基-4-噻唑酮类衍生物,其结构经mp、1H NMR和MS确证。抑菌活性试验显示,所有目标化合物表现出中等抑菌活性。其中化合物4的抑菌活性最高能达到62.7%。构效关系研究表明在2,3-二苯基-4-噻唑酮的苯基上引入甲基能增强活性。 英文摘要: A series of 2, 3-diphenyl-4-thiazolidinone derivatives were synthesized and characterized by mp,1H NMR and MS. Their antifungal activities were also evaluated in vitro at the concentration of 100 μg/mL against seven phytopathogenic fungi, namely Fusarium graminearum, Alternaria alternata, Fusarium oxysporium f. sp. vasinfectum, Pyricularia oryzae, Valsa mali, Alternaria solani and Alternaria brassicae. Amang of all compounds, 4g demonstrated a potential antifungal activity with the highest inhibition rates of 62.7%. Introduction of the methyl group at the phenyl ring of 4-thiazolidinone derivatives could generally increase the potency. 查看全文查看/发表评论下载PDF阅读器 相关附件：版权转让声明书 -->