Wenjing Zhao
Ping Lan
Xiangyu Mou
Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, School of Medicine, Sun Yat-sen University, Guangzhou 510275, China
Funds: We thank Drs. Xiaojian Wu, Zhen He and Jia Ke for helpful discussion. We thank Peijie Li for assisting preparation of this manuscript. This work has been supported by National Key Research and Development Program of China (No. 2017YFC1308800), the Fundamental Research Funds for the Central Universities (19ykzd33, Sun Yat-sen University) and the National Natural Science Foundation of China (Grant No. 31900056).
Received Date: 2020-02-10
Rev Recd Date:2020-05-30
Abstract
Abstract
Inflammatory bowel disease (IBD) has become a global disease with accelerating incidence worldwide in the 21st century while its accurate etiology remains unclear. In the past decade, gut microbiota dysbiosis has consistently been associated with IBD. Although many IBDassociated dysbiosis have not been proven to be a cause or an effect of IBD, it is often hypothesized that at least some of alteration in microbiome is protective or causative. In this article, we selectively reviewed the hypothesis supported by both association studies in human and pathogenesis studies in biological models. Specifically, we reviewed the potential protective bacterial pathways and species against IBD, as well as the potential causative bacterial pathways and species of IBD. We also reviewed the potential roles of some members of mycobiome and virome in IBD. Lastly, we covered the current status of therapeutic approaches targeting microbiome, which is a promising strategy to alleviate and cure this inflammatory disease.Keywords: inflammatory bowel disease,
pathogenesis,
etiology,
microbiome,
dysbiosis,
therapy
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