Hongfei Cui
Mingran Yang
Shiyu Du
Junfeng Li
Yingxue Li
Liyang Liu
Xuegong Zhang
Shao Li
1 MOE Key Laboratory of Bioinformatics and TCM-X center/Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing 100084, China;
2 China-Japan Friendship Hospital, Beijing 100029, China;
3 Institute for Artificial Intelligence and Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China;
4 School of Life Sciences and Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China
Funds: This study was supported by the National Natural Science Foundation of China (Grant Nos. 81630103, 91729301, 91229201 and 81225025) and the Project of Tsinghua-Fuzhou Insititute for Data Technology (TFIDT2018001) to S. Li and grants 61673231 and 61721003 to X. Zhang.
Received Date: 2018-09-18
Abstract
Abstract
The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progress. In this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrence and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis.Keywords: gastritis,
tongue coating,
metagenomics,
Campylobacter concisus,
non-invasive biomarker
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