Ran Pan
Wenjing Zhang
Junfen Fu
Jiandie D. Lin
Zhuo-Xian Meng
1 Department of Pathology and Pathophysiology, Key Laboratory of Disease Proteomics of Zhejiang Province, School of Medicine, Chronic Disease Research Institute of School of Public Health, Zhejiang University, Hangzhou 310058, China;
2 Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;
3 Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Funds: by National Natural Science Foundation of China (Grant Nos. 81570759 and 81270938), National Key Research and Development Programme of China (No. 2016YFC1305301), Zhejiang Provincial Key Science and Technology Project (No. 2014C03045-2), Key Disciplines of Medicine (Innovation discipline,11-CX24) to J.F.
and by NIH grant (No. DK112800) to J.D.L.
This work was supported by the National Natural Science Foundation of China (Grant No. 81670740), the Thousand Young Talents Plan of China, and the National Key Research and Development Programme of China (No. 2016YFC1305303) to Z.X.M.
Received Date: 2017-05-16
Rev Recd Date:2017-06-21
Abstract
Abstract
Metabolic syndrome has become a global epidemic that adversely affects human health. Both genetic and environmental factors contribute to the pathogenesis of metabolic disorders; however, the mechanisms that integrate these cues to regulate metabolic physiology and the development of metabolic disorders remain incompletely defined. Emerging evidence suggests that SWI/SNF chromatin-remodeling complexes are critical for directing metabolic reprogramming and adaptation in response to nutritional and other physiological signals. The ATP-dependent SWI/SNF chromatin-remodeling complexes comprise up to 11 subunits, among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit has three members, BAF60a, b, and c. The distinct tissue distribution patterns and regulatory mechanisms of BAF60 proteins confer each isoform with specialized functions in different metabolic cell types. In this review, we summarize the emerging roles and mechanisms of BAF60 proteins in the regulation of nutrient sensing and energy metabolism under physiological and disease conditions.Keywords: BAF60a,
BAF60b,
BAF60c,
chromatinremodeling,
SWI/SNF,
energy metabolism,
nutrient sensing,
glucose,
lipid,
skeletal muscle,
liver
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