姓名：张红 性别：女 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：帕金森病及肿瘤信号转导通路的调控及治疗 电子信箱：hzhang@ccmu.edu.cn


社会任职
1. 神经生物学系教育部神经变性病学重点实验室课题组主持人（PI)之一
2. 首都医科大学侨联委员
个人简历
1. 198609-199007:山西大学 生物化学专业本科
2. 199007-199904:山西医科大学 细胞与遗传学系，任教
3. 199309-199607:山西大学 微生物学专业研究生
4. 199904-199907:美国Emory大学，Winship肿瘤所 进修学习
5. 199908-200212:美国Emory大学，Winship肿瘤所 Research Associate
6. 200301-200609:美国Emory大学，生物化学系氧化还原实验室 Senior Research Associate
7. 200609-201107:首都医科大学,细胞生物学系 教授
8. 200901-200904:美国North Texas大学健康研究中心 访问
9. 200904-201107:首都医科大学，细胞生物学系 教授
10. 201107-:首都医科大学，神经生物学系,教育部神经变性病学重点实验室 教授
重要学术论文
1. WY Luo#, SQ Xing , P Zhu, CG Zhang, HM Yang, Halm-Lutterodt N Van, L Gu*, H Zhang*.PDZ scaffold protein CAL couples withmetabotropic glutamate receptor 5 to protect against cell apoptosis and is a potential target in the treatment of Parkinson's Disease. Neurotherapeutics. 2019,16(3):761-783.SCI
2. LH Bao#, YN Zhang#, JN Zhang, L Gu, HM Yang, YY Huang, N Xia, H Zhang*.Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson's disease. Journal of Neuroinflammation. 2018,15(1):131-145.SCI
3. YY Huang#, Q Zhang#, JN Zhang, YN Zhang, L Gu, HM Yang, N Xia, XM Wang, H Zhang*.Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease. Brain, Behavior, and Immunity. 2018,71(2018):93-107.SCI
4. XX Bai#, LGu#, HM Yang, SS Xi, N Xia, S Zhang, H Zhang*.Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model. Toxicology Letters. 2018,288(2018):71-81.SCI
5. SS Xi, XX Bai, L Gu, LH Bao, HM Yang, W An, XM Wang , H Zhang*.Metabotropic glutamate receptor 5 mediates the suppressive effect of 6-OHDA-induced model of Parkinson's disease on liver cancer. Pharmacological Research. 2017,121:145-157.SCI
6. L Gu#, W Gao#, HM Yang, BB Wang, XN Wang, J Xu, H Zhang*.Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21. Journal of Biochemistry. 2016,159(1):101-110.SCI
7. N Xia, Q Zhang, ST Wang, L Gu, HM Yang, R Bakshi, H Yang, H Zhang*.Blockade of metabotropic glutamate receptor 5 protects against DNA damage in a rotenone-induced Parkinson's disease model. Free Radical Biology and Medicine. 2015,89(2015):567-580.SCI
8. SQ Xing#, CG Zhang#, JF Yuan#, HM Yang, SD Zhao, H Zhang*.Adiponectin induces apoptosis in hepatocellular carcinoma through differential modulation of thioredoxin proteins. Biochemical Pharmacology. 2015,93(2015):221-231.SCI
9. JW Zhu#, JF Yuan#, HM Yang, ST Wang, CG Zhang, LL Sun, H Yang*, H Zhang*.Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic. Biochimie. 2012,94(3):617-627.SCI
10. LL Sun#, L Gu#, ST Wang, JF Yuan, HM Yang, JW Zhu, H Zhang*.N-acetylcysteine Protects against Apoptosis through Modulation of Group I Metabotropic Glutamate Receptor Activity. Plos One. 2012,7(3):e32503.SCI
11. YL Wu#, NN Wang#, L Gu, HM Yang, N Xia , H Zhang*.The suppressive effect of metabotropic glutamate receptor 5 (mGluR5) inhibition on hepatocarcinogenesis. Biochimie. 2012,94(11):2366-2375.SCI
12. S Cheng, JQ Zhang, P Zhu, YM Ma, Y Xiong, LC Sun, JG Xu, H Zhang, JQ He.The PDZ domain protein CAL interacts with mGluR5a and modulates receptor expression. Journal of Neurochemistry. 2010,112(3):588-98.SCI
13. JQ Zhang, S Cheng, Y Xiong, YM Ma, DL Luo, A Jeromin, H Zhang(共同责任作者), JQ He.A Novel Association of mGluR1a with the PDZ Scaffold Protein CAL Modulates Receptor Activity. FEBS Letters. 2008,582:4117–4124.SCI
14. H Zhang, YM Go, DP Jones.Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress. Archives of Biochemistry and Biophysics. 2007,456(1):119-126.SCI
15. JM Hansen, H Zhang, DP Jones.Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-{alpha}-induced ROS generation, NF-{kappa}B activation and apoptosis. Toxicological Sciences. 2006,91(2):643-650.SCI
16. SD Taylor, H Zhang(并列第一), JS Eaton, MS Rodeheffer, MA Lebedeva, TW O’rourke, W Siede, GS Shadel.The Conserved Mec1/Rad53 Nuclear Checkpoint Pathway Regulates Mitochondrial DNA Copy Number in Saccharomyces cerevisiae. Molecular Biology of the Cell. 2005,16(6):3010-3018.SCI
17. R Pabla, V Pawar, H Zhang, W siede.Characterization of checkpoint responses to DNA damage in Saccharomyces cerevisiae: basic protocols. Methods Enzymol. 2005,409:101-117.SCI
18. H Zhang, J Taylor, W Siede.Checkpoint arrest signaling in response to UV damage is independent of nucleotide excision repair in Saccharomyces Cerevisiae. Journal of Biological Chemistry. 2003,278(11):9382-9387.SCI
19. H Zhang, W Siede.Validation of a novel assays for checkpoint responses:characterizition of camptothecin derivatives in Saccaromyces cerevisiae. Mutation Research. 2003,527(1-2):37-48.SCI
20. H Zhang and W Siede.UV-Induced T-C transition site at a TT photoproduct is dependent on Saccharomyces Cerevisiae polymerase in vivo. Nucleic Acids Research. 2002,30:1262-1267.SCI
21. H Zhang, Z Zhu, G Idanes, D Mbangkollo, Y Liu, W Siede.Characterization of DNA damage–stimulated self-interaction of Saccharomyces Cerevisiae checkpoint protein Rad17. Journal of Biological Chemistry. 2001,276:26715-26723.SCI
主编或副主编的著作/译著
1. 《细胞信号转导研究技术》,副主编,中国协和医科大学出版社,200808
重要奖项