佟伟民科研领域与方向： 本课题组是中国医学科学院基础医学研究所兼协和佟伟民教授于2007年回国成立的科研团队。近期的研究工作主要集中在以下方向：
1. RNA m6A甲基化在神经发育及神经系统疾病中的作用与机制研究；
2. 蛋白质磷酸酶在神经发育过程中及神经系统疾病中的作用与机制研究；
3. DNA羟甲基化在上皮及神经细胞的退行及恶性转变过程中的功能探索；
4. DNA损伤修复因子在早期神经发育与神经系统疾病中的功能研究。

研究队伍： 课题组长：佟伟民 教授



佟伟民，北京协和医学院/中国医学科学院基础医学研究所病理学系，协和。1986中国医科大学医学学士，1991白求恩医科大学病理学硕士，1996奥地利维也纳大学(University of Vienna)理学博士，1997-2000世界卫生组织国际癌症研究署(IARC/WHO)博士后，2000-2007 IARC/WHO研究员。2007年9月回国。主要研究方向是探讨参与DNA损伤修复的蛋白质在DNA损伤应激反应过程中的相互作用及其生物学意义。利用遗传工程修饰(常规的或组织细胞特异性)DNA损伤修复基因小鼠，在整体、细胞和分子水平深入研究其蛋白在上皮细胞和神经细胞恶性转化中的作用机制。通过建立神经元变性病及神经源性肿瘤的模式动物，为发现新的疾病干预及治疗方法提供理论基础。在Molecular Cell Biology, Cancer Research, American Journal ofPathology, Nature Medicine, DNA Repair, Oncogene, Cancer Cell, Open Biology,Cell Research等杂志共发表SCI论文50余篇。

副研究员：牛亚梅 博士
2013-至今
北京协和医学院/中国医学科学院基础医学研究所，副研究员

2009-2013
中国科学院北京基因组研究所，副研究员

2007-2009
日本久留米大学医学部，博士后

2004-2005
WHO国际癌症研究署（IARC/WHO），博士后

2000-2003
日本长崎大学药学部，药学博士


主要在研项目： 1.国家自然科学基金面上项目，2项（2015-2018）
2.中国医学科学院医学与健康科技创新工程重大协同创新项目，2项（2016-2020）

代表性论文: (#共同第一作者；*共同通讯作者) 1.Ma CH#, Chang MQ#, Lv HY#, Zhang ZW, Zhang WL, He X, Wu GL, Zhao SL,Zhang Y, Wang D, Teng XF, Liu CY, Li Q, Klungland A, Niu YM*, Song SH*, Tong W-M*.(2018) RNA m6A Methylation Participates in Regulation of Postnatal Developmentof the Mouse Cerebellum. Genome Biology. In Press.
2.Chang MQ#, Lv HY#, Zhang WL, Ma CH, He X, Zhao SL, Zhang ZW, Zeng Y-X,Song SH, Niu YM*, Tong W-M*. 2017 Region specific RNA m6Amethylation represents a new layer of control in the gene regulatory network inthe mouse brain. Open Biology 7 (9) :170166
3.Yang H, Liu P, Zhang J, Peng X, Lu Z, Yu S, Meng Y, Tong W-M*, Chen J*. (2015). Long noncoding RNA MIR31HG exhibitsoncogenic property in pancreatic ductal adenocarcinoma and is negativelyregulated by miR-193b. Oncogene, 35(28):3647.
4.Zheng G, Dahl JA, Niu Y, FuY, Klungland A, Yang YG, He C*. (2013). Sprouts of RNAepigenetics: the discovery of mammalian RNA demethylases. RNABiology, 10:6, 1-4
5.Niu Y, Zhao X, Wu YS, Li MM, Wang XJ, Yang YG*. (2013).N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigeneticfunction. Genomics Proteomics & Bioinformatics, 11, 8-17.
6.Zheng G#, Dahl JA#, Niu Y#,Fedorcsak P, Huang CM, Li CJ, V?gb? CB, Shi Y, Wang WL, Song SH, Lu Z, BosmansRP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y,Jia G, Zhao X, Liu J, Krokan HE, Klungland A*, Yang YG*, He C*. (2013). ALKBH5is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. MolecularCell 49, 1-12.
7.Li MM#, Nilsen A#, Shi Y#, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, JinKX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A*, Yang YG*. (2013). ALKBH4-dependentdemethylation of actin regulates actomyosin dynamics. NatureCommunication, 4, 1832.
8.Li R, Yang YG, Gao Y, Wang ZQ, TongW-M*（2012）A distinct response to endogenous DNA damage in thedevelopment of Nbs1-deficient cortical neurons. Cell Research, 22,859-872
9.Guan J#, Tong W-M#, Ding W#, DuS, Xiao Z, Han Q, Zhu Z, Bao X, Shi X, Wu C, Cao J, Yang Y, Ma W, Li G, Yao Y,Gao J, Wei J, Dai J*, Wang R*（2012） Neuronal regeneration and protection by collagen-bindingBDNF in the rat middle cerebral artery occlusion model. Biomaterials, 33:1386-1395
10. Lee MK, Teoh WW, Phang BH, TongW-M, Wang ZQ, Sabapathy K* (2012) Cell-type, dose and mutation-typespecificity dictate mutant p53 functions in vivo. Cancer Cell, 22, 751-764
11. Gao M, Rendtlew Danielsen JM, Wei LZ, Zhou DP, Xu Q, Ping XL, Li MM,Wang ZQ, Tong W-M, Yang YG*. (2012) Anovel role of GEN1 inthemaintenance of genomic stability via centrosome regulation. PLoSONE, 7(11), e49687
12. LeeMK，Tong W-M,Wang ZQ, Sabapathy K*. (2011) Serine 312 phosphorylation is dispensable for wild-type p53 functionsin vivo. Cell, Death &Differentiation, 18, 214-221
13. MinWK, Cortes U, Herceg Z, Tong W-M,Wang ZQ*. (2010) Deletion of the nuclear isoform of poly(ADP)-ribose) glycohydrolase(PARG) reveals its function in DNA repair, genomic stability and tumorigenesis. Carcinogenesis 31, 2058-2065
14.Niu Y, Komatsu N, Komohara Y, Matsueda S, Yutani S,Ishihara Y, Itou M, Yamada A, Itoh K, Shichijo S*. (2009). A peptide derivedfrom hepatitis C virus (HCV) core protein inducing cellular responses inpatients with HCV with various HLA class IA alleles. Journal of Medical Virology, 81, 1232-1240.
15.Niu Y, Terasaki Y, Komatsu N, Noguchi M, Shichijo S*, Itoh K. (2009). Identification of peptidesapplicable as vaccines for HLA-A26-positive cancer patients. CancerScience, 100, 2167-2174.
16.Terasaki Y, Shichijo S*, Niu Y,Komatsu N, Noguchi M, Todo S, Itoh K. (2009). AnHLA-A3-binding prostate acid phosphatase-derived peptide can induce CTLsrestricted to HLA-A2 and -A24 alleles. Cancer Immunology, Immunotherapy:CII 58, 1877-1885.
17.Lee S, Huang H, Niu Y, Tommasino M, Lenoir G, Sylla BS*. (2007). Dok1 expression andmutation in Burkitt's lymphoma cell lines. Cancer Letters 245, 44-50.
18.Tong W-M*, Yang YG,Cao WH, Galendo D, Frappart L, Shen Y, Wang ZQ (2007) Poly(ADP-ribose)polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. Oncogene 26 : 3857-3867
19.Yang YG, Frappart PO, Frappart L, Wang ZQ, Tong W-M* (2006) A novel function ofDNA repair molecule Nbs1 interminal differentiation of the lens fibre cells and cataractogenesis. DNARepair 5: 885-893
20.Niu Y, Roy F,Saltel F, Andrieu-Soler C, Dong W, Chantegrel AL, Accardi R, Thépot A, FoiselleN, Tommasino M, Jurdic P, Sylla BS*. (2006). A nuclear export signal andphosphorylation regulate Dok1 subcellular localization and functions. Molecularand Cellular Biology, 26, 4288-4301.
21.Frappart PO, Tong W-M, Demmuth I, Radovanovic I, Herceg Z, Aguzzi A, Digweed M, WangZQ*. (2005) An essential function for NBS1 inthe prevention of ataxia and cerebellar defects. Nature Medicine 11:538-544
22.Cortes U, TongW-M, Coyle DL, Meyer-Ficca ML, Meyer RG, Petrilli V, Herceg Z, Jacobson EL,Jacobson MK, Wang ZQ*. (2004) Depletion of the 110-kilodalton isoformpoly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic andendotoxic stress. Molecular and Cellular Biology 24:7163-7178
23.Tong W-M, OhgakiH, Huang H, Granier, C, Kleihues P, Wang ZQ*. (2003) Null mutation of DNAstrand break-binding molecule poly(ADP-ribose) polymerase causesmedulloblastomas in p53-/- mice. American Journal of Pathology. 162:343-352
24.Niu Y, MurataT*, Watanabe K, Kawakami K, Yoshimura A, Inoue J, Puri RK, Kobayashi N. (2003). MIP-T3 associates with IL-13Ralpha1and suppresses STAT6 activation in response to IL-13 stimulation. FEBSLetters 550, 139-143.

联系地址：
中国医学科学院基础医学研究所病理学系
北京东单三条5号，100005
电话：010 6915 6945
E-mail：wmtong(AT)ibms.pumc.edu.cn