刘力

研究方向：病毒RNA调控及肿瘤信号通路
介绍：刘力,男，博士，研究员，博士生导师。康奈尔大学医学院博士后，南开大学分子病毒学博士。从1991年1月起,先后在美国国家动物疾病中心、康奈尔大学医学院及斯隆凯特林研究所(Sloan Kettering)从事多年动物呼吸道病毒的免疫生物学及人腺病毒转录后期RNA加工的基因调控等方面的研究工作。1998年6月回国，历任中国医学科学院基础医学研究所/北京协和医学院基础学院病原微生物研究室副研究员，研究员，博士研究生指导教师。2001-2007,清华大学基因组研究所兼职副教授，博士研究生副指导教师。2004年起任《基础医学与临床》常务编委。2014年起《Frontiers in Bioscience》执行编辑(managing editor),2017年起任编辑(editor)。2016年起《转化医学电子杂志》编委， 2017年起《转化医学电子杂志》学术委员。2017年起为《Cancer Translational Medicine》杂志编委。现为美国微生物学会贡献会员，欧美同学会医师学会会员，中国微循环学会会员，中国微循环学会转化医学专业委员会常务委员。国家科技重大专项-重大新药创制（2017）答辩专家，国家自然科学基金委员会面上项目函审专家，北京市自然科学基金面上项目函审专家、北京市丰台区科委重点项目答辩专家、天津市自然科学基金面上项目及基金函审专家，天津市自然科学基金委员会基金答辩专家、浙江省自然科学基金项目函审专家，四川省科学技术奖励函审专家，河北省自然科学基金函审专家，黑龙江省自然科学基金函审专家，教育部学位中心学位论文函审专家。为The Lancet, Molecular Pharmaceutics, PLoS One, BBA-Molecular Cell Research, Antiviral Res, BMC Cancer等十八家国际SCI期刊同行评议专家。在中文核心期刊及SCI期刊发表研究论文共70余篇，其中在Cancer Res, mBio, Mol Cell Biol等国际主流杂志发表SCI研究论文32篇（第一及通讯作者文章27篇）。已培养毕业硕士研究生18名，博士研究生9名。

联系方式：办公室电话: **
电子邮件地址: lliu@pumc.edu.cn
通信地址: 北京市东城区东单三条五号老科研楼336室

主要英文论文(*通讯或共同通讯作者)
1.Yajuan Gao, Li Liu*. Multifunction of cytosolic DNA sensor. Journal of Advances in Health, 2019, 1(1): 49-56.
2. Sulin Zeng, Wen H. Shen*, Li Liu*. Senescence and Cancer. Cancer Translational Medicine 2018,4(3):70-74.
3. Li Liu*, Wei Chen. Leader sequences of coronavirus are altered during infection. Frontiers in Bioscience-Landmark, 2018, Jan 1, 23: 27-35.
4. Yi-Rong Xiang, Li Liu*，2Eating2cancer cells by blocking CD47 signaling: cancer therapy by targeting the innate immune checkpoint. Cancer Translational Medicine 2017, 3(6):200-208.
5. We-Ye Shi, Xiao Yang, Bo Huang, Wen H Shen, Li Liu*. NOK mediates glycolysis and nuclear PDC associated histone acetylation. Frontiers in Bioscience-Landmark, 2017, 22:1792-1804.
6.Shi WY, Cao C, Li Liu*. Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.Int J Mol Sci. 2016 Nov 2;17(11). pii: E1832.
7. Yi Wang and Li Liu*. The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern to Promote Beta Interferon Induction via a Toll-Like- Receptor-Related TRAF3-Independent Mechanism. mBio, 2016,(1): e01872- 15. (Cover story)
8. Zhiqiang Xia, Fang Liu, Jian Zhang and Li Liu*. Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion. PLoS One, 2015, 10(7):e**.
9. Sheng-Qi Hou and Li Liu*. NOK mediated mitogenic signaling is altered by P203L and V395I mutations. Front Biosci (Landmark Ed), 2015, 20:1179-89.
10. Xu G, Gao Z, He W, Ma Y, Feng X, Cai T, Lu F, Liu L, Li W*. microRNA expression in hepatitis B virus infected primary treeshrew hepatocytes and the independence of intracellular miR-122 level for de novo HBV infection in culture.Virology. 2014 Jan 5;448:247-54..
11. Shi WY, Che CY, Li Liu*. Human interleukin 23 receptor induces cell apoptosis in mammalian cells by intrinsic mitochondrial pathway associated with the down-regulation of RAS/mitogen-activated protein kinase and signal transducers and activators of transcription factor 3 signaling pathways.Int J Mol Sci. 2013 Dec 18;14(12):24656-69..
12. Rong Guo, Yi Wang, Wei-Ye Shi, Bin Liu, Sheng-Qi Hou and Li Liu*. MicroRNA miR-491-5p Targeting both TP53 and Bcl-XL Induces Cell Apoptosis in SW1990 Pancreatic Cancer Cells through Mitochondria Mediated Pathway. Molecules 2012, 17(12), 14733-14747.
13. Ying-Li Cao, Ying Wang, Rong Guo, Fan Yang, Yun Zhang, Shu-Hui Wang, Li Liu*. Identification and characterization of three novel small interference RNAs that effectively down-regulate the isolated nucleocapsid gene expression of SARS coronavirus. Molecules, 2011 Feb 11;16(2):1544-58.
14. Ying Wang, Ying-Li Cao, Fan Yang, Yun Zhang, Shu-Hui Wang, Li Liu*. Small interfering RNA effectively inhibits the expression of SARS coronavirus membrane gene at two novel targeting sites. Molecules, 2010 Oct 18;15(10):7197-207.
15. Xue Yao, Yang Su, Chang Liu, Juan Tan, Li Liu, Yun-Qi Geng, Wen-Tao Qiao*. Establishment of an indicator cell line for monitoring bovine immunodeficiency virus infection and inhibitor susceptibility. J Virol Methods. 2010 Jan;163(1):25-30.
16. Fan Yang, Yu-Ping Xu, Jian Li, Su-Su Duan, Ying-Jie Fu, Yun Zhang, Yan Zhao, Wen-Tao Qiao, Qi-Min Chen, Yun-Qi Geng, Chang-Yan Che, Ying-Li Cao,Ying Wang, Lei Zhang, Lin Long, Jie He, Quan-Cai Cui, Shu-Chang Chen, Shu-Hui Wang, Li Liu*. 2009. Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression. The International Journal of Biochemistry and Cell Biology, 41(11):2240-2250.
17. Li Liu, Jian Li, Yu-Ping Xu, Wen-Tao Qiao, Qi-Min Chen, Yun-Qi Geng*. RNA silencing suppressor p19 regulates the expressions of cell cycle related genes. Progress in Biochemistry and Biophysics (rapid communications), 2009 May, 36(5): 541-548.
18. Ying-Hua Li, Yin-Yin Wang, Shan Zhong, Zhi-Li Rong, Yong-Ming Ren, Zhi-Yong Li, Shu-Ping Zhang, Zhi-Jie Chang, Li Liu*. Transmembrane helix of novel oncogene with kinase-domain (NOK) influences its oligomerization and limits the activation of RAS/MAPK signaling. 2009 January, Mol Cells, Vol. 27(1): 39-45.
19. Ying-Hua Li, Yu Rong, Zhijie Chang, Li Liu*. 2008. NOK activates stat3 signaling by a Jak2-dependent mechanism. Progress in Biochemistry and Biophysics (rapid communications), 35(2):143-150.
20. Ying-Hua Li, Zhijie Chang, Li Liu*. 2008. NOK interacts with akt and enhances its activation. Progress in Biochemistry and Biophysics (rapid communications), 35(1):29-34.
21. Zhe Ma, Peng Hao, Xue Yao, Chang Liu, Juan Tan, Li Liu, Rongge Yang, Yunqi Geng, Qimin Chen* and Wentao Qiao*. 2008. Establishment of an indicator cell line to quantify Bovine Foamy Virus infection. Journal of Basic Microbiology, 48(4): 278–283.
22. Ying-Hua Li, Shan Zhong, Zhi-Li Rong, Yong-Ming Ren, Zhi-Yong Li, Shu-Ping Zhang, Zhijie Chang, Li Liu*. 2007. The carboxyl terminal tyrosine 417 residue of NOK has an autoinhibitory effect on NOK-mediated signaling transductions. Biochemical and Biophysical Research Communications, 356(2):444-9.
23. Li Liu*. 2006. Functional characterization of the C-terminal domain of mouse capping enzyme. Cell Biochemistry and Function, 35(2):143-150;
24. Yu Rong, Long Cheng, Hongxiu Ning, Jizhen Zou, Yuanjiang Zhang, Fang Xu, Li Liu, Zhijie Chang*, and Xin-Yuan Fu*. 2006. Wilms' Tumor 1 and Signal Transducers and Activators of Transcription 3 Synergistically Promote Cell Proliferation: A Possible Mechanism in Sporadic Wilms' Tumor. Cancer Res, 66: 8049-8057.
25. Xiang-Yue Zhang, Hai-Jing Zhang, Yun Zhang, Ying-Jie Fu, Jie He, Li-Ping Zhu, Shu-hui Wang, Li Liu*. 2006. Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Immunogenetics, Vol 57(12): 934-943.
26. Tie-Shi Li, Xue-Ni Li, Zhi-Jie Chang, Xin-Yuan Fu, and Li Liu*. 2006. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen- activated protein kinase signaling pathway. Cellular Signaling, 18(8):1287-98.
27. Li Liu*. 2005. Characterization of an upstream regulatory element of adenovirus L1 poly (A) site. Virology, 337(1):124-35.
28. Yue Chen, Ying-Hua Li, Xi-Ping Chen, Li-Ming Gong, Shu-Ping Zhang, Zhi-Jie Chang, Xiu-Fang Zhang*, Xin-Yuan Fu*, and Li Liu*. 2005. Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice. Cancer Res.65 (23): 10838-10846.
29. Fan Yang, Yun Zhang, Ying-Li Cao, Shu-Hui Wang , and Li Liu*. 2005. Establishment and utilization of a tetracycline-controlled inducible RNA interfering system to repress gene expression in chronic myelogenous leukemia cells. Acta Bioch. Biophys. Sin. (Shanghai), 37(12):851-6.
30．Li Liu*, Xin-Zi Yu, Tie-Shi Li, Lian-Xia Song, Pei-La Chen, Ying-Hua Li, Shi-Dong Wang, Yue Chen, Yong-Ming Ren, Shu-Ping Zhang, Zhi-Jie Chang, and Xin-Yuan Fu*. 2004. A novel protein tyrosine kinase NOK that shares homology with PDGF/FGF receptors, induces tumorigenesis and metastasis in nude mice. Cancer Res., 64 (10): 3491-3499..
31．Shiqin Xiong, Qiuhui Zhao, Zhili Rong, Guanrong Huang, Yiling Huang, Peila Chen, Shuping Zhang, Li Liu, Zhijie Chang*. 2003. hSef inhibits PC-12 cell differentiation By interfering with Ras-mitogen-activated protein kinase MAPK signaling. J Biol Chem, 278(50):50273-82.
32. Li Liu, Howard D. Lehmkuhl*, and Malin L. Kaeberle. 1999. Synergistic effects of bovine respiratory syncytial virus and non-cytopathic bovine viral diarrhea virus on selected bovine alveolar macrophage functions. Can.J. Vet.Med., 63(1): 41-48.
33．Li Liu*, Shuhui Wang. 1999. The reversible inhibition of mimosine on rDNA plasmid replication in unfertilized Xenopus eggs. Chinese Science Bulletin, Vol 44(18): 1669-1672.
34．John C. Prescott#, Li Liu#, and Erik Falck-Pedersen*. 1997. Sequence- mediated regulation of adenovirus gene expression by repression of mRNA accumulation. Mol. Cell. Biol., 17:2207-2216. (#equal contribution，1997 SCI IF=10.025)
教材与专著章节（近5年）

1）刘力参编，第四章病毒DNA基因组复制。【分子病毒学】第三版/研究生，主编黄文林，人民卫生出版社，出版时间：2016年6月。书号ISBN：20;
2）刘力参编，第三十一章其他重要病毒。【医学微生物学学习指导及习题集】，主编李明远，人民卫生出版社，2016年3月第1版, 2016年3月第一次印刷p233-240。书号ISBN 978-7-117-21777-4/R·21778;
3）Li Liu. Chapter 19. The NOK receptor family, book name: Receptor Tyrosine kinases: family and subfamilies, edited by Deric L. Wheeler and Yosef Yarden, published in January 2015 by Humana Press, p843－859.
4）刘力参编，第三十一章其他重要病毒。【医学微生物学】第三版/长学制，主编李明远、徐志凯，人民卫生出版社，2015年6月第3版第一次印刷，p413－429.书号ISBN 978-7-117-20499-6/R ×20500;