王婧王婧 女 博士生导师

主要学习、工作经历：
2014年基础所院“引进人才”，任病理生理系研究员。主要从事重大心脑血管疾病的发病机制的研究工作。

研究方向：
1. 炎症与心血管疾病
2. 非编码RNA与心血管疾病
3. 干细胞与心血管疾病

课题组成员：
1. 工作人员： 李瑶 技师；赵红梅 助理研究员；闫莉 讲师
2. 直博生： 高冉（毕业于天津医科大学）；舒婷（毕业于北京大学医学部）； 葛伟鹏（毕业于大连医科大学）
3. 硕士研究生：张唯（毕业于中国医科大学）；宋小敏（毕业于华中农业大学）； 邹璇（毕业于湖南大学）；郭文钧（毕业于辽宁师范大学）

联系方式 ：
电话：**
Email:wangjinglab@hotmail.com

主要获奖情况：
2016 优秀青年科学基金

代表论文：
1. Wang Z, Ni L, Wang J#, Lu C, Ren M, Han W, Liu C#. The protectiveeffect of melatonin on smoke-induced vascular injury in rats and humans: arandomized controlled trial. J Pineal Res. 2016 Mar;60(2):217-27.
2. Guo X, Yuan S, Liu Y, Zeng Y, Xie H, Liu Z, Zhang S, Fang Q, WangJ#, Shen Z#. Serum IgE levels are associated with coronary artery diseaseseverity. Atherosclerosis. 2016 May 12. pii: S0021-9150(16)30197-6.
3. Lv BJ, Lindholt J, Cheng X, Wang J#, Shi GP#. Plasma cathepsin Sand cystatin C levels and risk of abdominal aortic aneurysm: a randomizedpopulation –based study. Plos One,2012,7(7): e41813. Jul 23
4. Wang J*, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, ZhouY, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, JiangM, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, JarolimP, Libby P, Shi GP. Interleukin 18 function in atherosclerosis is mediated bythe interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015Jul;21(7):820-6. doi: 10.1038/nm.3890. Epub 2015 Jun 22.
5. Wang J*, Cheng X, Xiang M, Kinnunen M, Wang J, Chen H, He A, Sun X,Lin Y, Tang TT, Tu X, Sjoberg S , Sukhova G, Liao YH, Conrad D, Yu LY, KawakamiT, Kovanen P, Libby P, Shi GP. IgE stimulates human and mouse arterial cellapoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice. JClin Invest., 2011 Sep;121(9):3564-77
6. Wang J*, Sj?berg S, Lindholt J, Xia M, Chen H, Xiong N, Sukhova G,Libby P, Shi GP. IgE promotes abdominal aortic aneurysm formation in Apoe–/–mice by regulating macrophage and T cell activation. EMBO Mol Med., 2014 Jun24;6(7):952-69
7. Cheng X*, Wang J*, Xia N, Yan XX, Tang TT, Chen H, Zhang HJ, Liu J,Kong W, Sj?berg S, Folco E, Libby P, Liao YH, Shi GP. A guanidine-rich regulatoryoligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-celldifferentiation. EMBO Mol Med., 2012, Oct;4(10):1112-25
8. Wang J*, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BCPhosphorylation of G Protein-Coupled Receptor Kinase 2-Interacting Protein 1Tyrosine 392 Is Required for Phospholipase C-{gamma} Activation and PodosomeFormation in Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol., 2010Oct;30(10):1976-82
9. Wang J*, Taba Y, Pang J, Yin G, Yan C, Berk BC. GIT1 mediatesVEGF-induced endothelial cell podosome formation-critic role for PLCγ.Arterioscler Thromb Vasc Biol., 2009 Feb;29(2):202-8
10. Wang J*, Pan S, Berk BC. Glutaredoxin mediates Akt and eNOSactivation by flow in a glutathione reductase-dependent manner. ArteriosclerThromb Vasc Biol., 2007 Jun;27(6):1283-8
11. Chen H*, Wang J*,Sjoberg S, Libby P, Shi GP. E64d DeterioratesPost-Myocardial Infarction Left Ventricular Remodeling by Inhibiting CathepsinS-Mediated Fibroblast Trans-Differentiation. Cardiovasc Res. 2013 Oct1;100(1):84-94
12. Wang J*, Sj?berg S, Tang TT, O?rni K, Wu W, Liu C, Secco B, Tia V,Sukhova GK, Fernandes C, Lesner A, Kovanen PT, Libby P, Cheng X, Shi GP.Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. BiochimBiophys Acta-molecular basis of disease. 2014 Nov;1842(11):2174-83
13. Wang J*, Sun J, Sj?berg S, Tia V, Secco B, Chen H, Shi GP.Pharmaceutical stabilization of mast cells attenuate experimental atherogenesisin low-density lipoprotein receptor-deficient mice Atherosclerosis, 2013,Aug;229(2):304-9.
14. Wang J*, Shi GP. Mast cell stabilization: Novel medication forobesity and diabetes. Diabetes/Metabolism Research and Review, 2011Nov;27(8):919-24
15. Wang J*, Sukhova GK, Liu J, Ozaki K, Lesner A, Libby P, Kovanen PT,Shi GP. Cathepsin G deficiency reduces periaortic calcium chlorideinjury-induced abdominal aortic aneurysms in mice. J Vasc Surg. 2014 Jul 16.pii: S0741-5214(14)01115
16. Chen H*; Wang J*; Shi GP “Role of Lysosomal Cathepsins inPost-Myocardial Infarction Remodeling “ North American Journal Medicine &Science, 2011 Oct, 4 (4): 173-178
17. Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X,O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC. G-protein-coupledreceptor kinase interacting protein-1 is required for pulmonary vasculardevelopment. Circulation, 2009 Mar 24;119(11):1524-32
18. Liao YH, Xia N, Zhou SF, Tang TT, Yan XX, Lv BJ, Nie SF, Wang J,Iwakura Y, Xiao H, Yuan J, Jevallee H, Wei F, Shi GP, Cheng X. Interleukin-17Acontributes to myocardial ischemia/reperfusion injury by regulatingcardiomyocyte apoptosis and neutrophil infiltration. Journal of the AmericanCollege of Cardiology, 2012 Jan 24;59(4):420-9
19. Lv BJ, Lindholt JS, Wang J, Cheng X, Shi GP. Plasma levels ofcathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomizedpopulation-based study. Atherosclerosis. 2013 Sep;230(1):100-5.
20. Pang J, Xu X, Wang X, Majumder S, Wang J, Korshunov VA, Berk BC.G-protein-coupled receptor kinase interacting protein-1 mediates intimaformation by regulating vascular smooth muscle proliferation, apoptosis, andmigration. Arterioscler Thromb Vasc Biol. 2013 May;33(5):999-1005