导师简介：赵丽娇




一、基本情况：
赵丽娇，博士，教授，博士生导师。北京工业大学生命科学与生物工程学院生物系副主任、学院党委委员，兼任中国化学会会员、世界理论与计算化学家协会(WATOC)会员、美国化学会会员等学术职务。入选2009年北京市“科技新星”计划、2008年北京市委组织部“优秀人才”计划、2015年北京工业大学“京华人才”计划，获得2015年北京市“留学人员科技活动项目择优资助”。主持和参与的科研项目包括国家级、省部级、所在单位及企业项目共26项，其中主持多项国家自然科学基金面上项目、青年基金、北京市自然科学基金面上项目等课题，参与国家863计划等项目。发表研究论文60余篇，其中SCI检索40余篇；获得发明专利授权4项、实用新型授权1项。
主要从事致癌作用机理及新型抗癌药物的研究，主要学术贡献包括：1、提出亚硝胺代谢活化导致DNA股间交联是其致癌作用的关键步骤；2、阐明了亚硝基脲抗癌和致癌作用机制的关键差异，并提出dG-dC交联作为评价双官能团亚硝基脲抗癌活性的生物标志物，为设计开发高效低毒的抗癌药物奠定了基础。2008年留学美国麻省理工学院生物工程系，进行有关慢性炎症与恶性肿瘤关系的研究；2012-2013年留学美国明尼苏达大学Masonic癌症中心，进行有关烟草特异亚硝胺导致食管癌的生物标志物研究；长期以来与香港中文大学微生物系合作开展有关人乳头瘤病毒(HPV)与环境因素的协同致癌作用研究。
主讲本科生《仪器分析》、《食品检测技术》和研究生《量子生物学》等课程，获得北京工业大学“优秀教学质量奖”和“优秀教育教学成果奖”等，主持校教育教学研究课题和研究生课程建设项目各1项。培养的研究生中有多人获得国家奖学金、北京市优秀毕业生、北京工业大学优秀学位论文、校科技之星和十佳毕业生等荣誉称号。

二、主要研究方向：
1. 环境致癌物对生物大分子的损伤作用及癌症生物标志物。
2. 致癌物的代谢和致癌作用机理及其分子结构与致癌活性关系。
3. 新型靶向性抗肿瘤药物的设计、合成及活性研究。
4. 烷化剂类抗肿瘤药物的耐药机制。

三、主持的主要科研项目：
1.国家自然科学基金面上项目（2018.01-2021.12，项目负责人）：
低氧激活联合亚硝基脲的作用机理及抗癌活性研究
2.北京市自然科学基金面上项目（2016.01-2018.12，项目负责人）：
新型靶向性抗耐药亚硝基脲类烷化剂的设计、合成及抗肿瘤活性研究
3.北京工业大学“京华人才”支持计划（2015.01-2017.12，项目负责人）：
新型靶向性亚硝基脲类抗癌药物的研究。
4.国家自然科学基金面上项目（2013.01-2016.12，项目负责人）：
环境中N-亚硝基化合物分子结构与致癌活性关系及其生物标志物研究。
5.北京市留学人员科技活动择优资助项目（2015.01-2015.12，项目负责人）：
烟草特异亚硝胺导致肺癌的生物标志物研究。
6.国家自然科学基金青年基金项目（2010.01-2012.12，项目负责人）：
N-亚硝基化合物对DNA的损伤作用机制及相关构效关系。
7.北京市科技新星计划B类（2010.01-2012.12，项目负责人）：
N-亚硝基化合物对DNA的损伤作用及致癌机理研究。
8.北京市自然科学基金预探索项目（2011.01-2012.06，项目负责人）：
烷基亚硝胺对DNA的损伤作用与其致癌靶器官之间的关系。
9.北京市委组织部优秀人才资助项目（2008.01-2009.12，项目负责人）：
癌症相关标志物及应用研究。

四、主要学术论文：
1.Yameng Wang, Ting Ren, Xinxin Lai, Guohui Sun, Lijiao Zhao*, Na Zhang, Rugang Zhong. Synthesis and antitumor activity evaluation of a novel combinitrosourea prodrug: BGCNU. ACS Medicinal Chemistry Letters, 2017, 8: 174-178. (SCI检索)
2.Guohui Sun, Tengjiao Fan, Lijiao Zhao*, Yue Zhou, Rugang Zhong. The potential of combi-molecules with DNA-damaging function as anticancer agents. Future Medicinal Chemistry, 2017, 9: doi: 10.4155/fmc-2016-0229. (SCI检索)
3.Guohui Sun, Lijiao Zhao*, Tengjiao Fan, Ting Ren, Rugang Zhong. Measurement of O-6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS/MS. Journal of Chromatography B, 2016, 1033: 138-146. (SCI检索)
4.Guohui Sun, Tengjiao Fan, Na Zhang, Ting Ren, Lijiao Zhao*, Rugang Zhong. Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking. Molecules, 2016, 21: 823-843. (SCI检索)
5.Guohui Sun, Na Zhang, Lijiao Zhao*, Tengjiao Fan, Shufen Zhang, Rugang Zhong. Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O-6-alkylguanine-DNA alkyltransferase. Bioorganic & Medicinal Chemistry, 2016, 24: 2097-2107. (SCI检索)
6.Guohui Sun, Lijiao Zhao*, Rugang Zhong. The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16: 221-246. (SCI检索)
7.Wensi Zhong, Ting Ren, Lijiao Zhao*. Determination of Pb (lead), Cd (cadmium), Cr (chromium), Cu (copper), and Ni (nickel) in Chinese tea with high-resolution continuum source graphite furnace atomic absorption spectrometry. Journal Food and Drug Analysis, 2016, 24: 46-55. (SCI检索)
8.Lili Li, Sisi Li, Guohui Sun, Ruizeng Peng, Lijiao Zhao*, Rugang Zhong. Influence of the Expression Level of O-6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry. Plos One, 2015, 10(3): UNSP e**. (SCI检索)
9.Guohui Sun, Lijiao Zhao*, Tengjiao Fan, Sisi Li, Rugang Zhong. Investigations on the effect of O⁶-benzylguanine on the formation of dG-dC interstrand crosslinks induced by chloroethylnitrosoureas in human glioma cells using a stable isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Chem. Res. Toxicol., 2014, 27(7): 1253-1262. (SCI检索)
10.Lili Li, Lijiao Zhao*, Rugang Zhong. Quanti?cation of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/ electrospray ionization tandemmass spectrometry. Rapid Comm. Mass Spectrom., 2014, 28(5): 439-447. (SCI检索)
11.Lijiao Zhao*, Lili Li, Jie Xu, Rugang Zhong. Comparative investigation of the DNA inter-strand crosslinks induced by ACNU, BCNU, CCNU and FTMS using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Int. J. Mass Spectrom., 2014, 368(7):30-36. (SCI检索)
12.Lijiao Zhao*, Silvia Balbo, Mingyao Wang, Pramod Upadhyaya, Samir S. Khariwala, Peter W. Villalta, Stephen S. Hecht^*. Quantitation of pyridyloxobutyl- DNA adducts in tissues of rats treated chronically with (R)- or (S)-N′-nitrosonornicotine (NNN) in a carcinogenicity study. Chem. Res. Toxicol., 2013, 26(10): 1526-1535. (SCI检索)
13.Tingting Liu, Lijiao Zhao*, Rugang Zhong. DFT study of phosphotriesters hydrolysis in aqueous solution: a model study for DNA single strand scission induced by N-nitrosoureas. J. Mol. Model., 2013, 19(2): 647-659. (SCI检索)
14.Lijiao Zhao*, Xinyan Ma, Rugang Zhong. A DFT investigation on the formation mechanisms of DNA interstrand crosslinks induced by chloroethylnitrosoureas. Int. J. Quantum Chem., 2013, 113(9): 1299-1306. (SCI检索)
15.Ting Ren, Lijiao Zhao*, Bosi Sun, Rugang Zhong. Determination of lead, cadmium, copper, and nickel in the Tonghui River of Beijing, China, by cloud point extraction-high resolution continuum source graphite furnace atomic absorption spectrometry. J. Environ. Qual., 2013, 42(6): 1752-1762. (SCI检索)
16.Lijiao Zhao*, Xinyan Ma, Rugang Zhong. Comparative theoretical investigation of the mechanism of DNA interstrand crosslinks induced by two N-nitroso compounds: nitrosoureas and nitrosamines. J. Phy. Org. Chem., 2012, 25(12): 1153-1167. (SCI检索)
17.Jun Cao, Lijiao Zhao*, Shubin Jin, Rugang Zhong. Relationship between the molecular structure and the anticancer activity of N-(2-chloroethyl)-N'-c yclohexyl-N-nitrosoureas: A theoretical investigation. Int. J. Quantum Chem., 2012, 112(3): 747-758. (SCI检索)
18.Lijiao Zhao*, Ting Ren, Rugang Zhong. Determination of lead in human hair by high resolution continuum source graphite furnace atomic absorption spectrometry with microwave digestion and solid sampling. Anal. Lett., 2012, 45(16): 2467-2481. (SCI检索)
19.Baoqing Bai, Lijiao Zhao*, Rugang Zhong. Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/ electrospray ionization tandem mass spectrometry. Rapid Comm. Mass Spectrom., 2011, 25(14): 2027-2034. (SCI检索)
20.Lijiao Zhao*, Tingting Liu, Rugang Zhong. A comparison of the stereoisomeric penta-coordinated phosphorus intermediates formed from 19 dimethoxyl N-phosphoryl amino acids by DFT calculations. J. Theor. Comput. Chem., 2011, 10(2): 217-229. (SCI检索)

五、招生方向：
1.博士研究生招生方向：
09（全日制）分子毒理学与癌症防治
59（非全日制）分子毒理学与癌症防治
2.硕士研究生招生方向：
0710生物学：04药物化学与化学生物学、05 环境生物学与食品安全
085230生物医学工程（专业学位）：04药物新技术与食品安全

六、联系方式：
北京市朝阳区平乐园100号，
北京工业大学生命科学与生物工程学院（北工大理科楼B213室）
邮政编码：100124
E-mail: zhaolijiao@bjut.edu.cn
手机：**