导师简介

一、基本情况
闫红，女，教授，博士生导师。1994年毕业于北京理工大学化工与材料学院，有机合成专业，获工学博士学位。一直从事具有生物化学的有机化合物的光化学合成及生物化学研究工作，具有药物设计、合成及活性测试研究方面的良好基础。在多面体烷及其衍生物的合成、抗病毒和抗肿瘤活性等方面，主持和参加了多项科研项目，申报发明专利10余项，获授权7项，并在国外和国内核心刊物上发表论文百余篇，获北京市科技进步三等奖二项，获北京市优秀青年骨干教师荣誉称号，并入选北京市科技新星计划。目前工作的重点是以药物合成和天然产物有效成分的提取、分离、改性等方法为基础进行的抗病毒、抗肿瘤等药物的合成研究（如：抗HIV病毒的蛋白酶、整合酶和阻断病毒进入的天然产物等的合成），以及创新药物的研发等。

二、研究方向
研究方向一：多面体烷类化合物的合成和药理活性筛选
研究方向二：新合成技术在药物合成中的应用
研究方向三、多糖类天然产物的提取分离和改性的研究

三、招生方向
0710 生物学: 04 药物化学与化学生物学和05环境生物系与食品安全
085230 生物医学工程（专业学位）: 04 药物新技术与食品安全
四、课题或论文情况
4.1项目
国家十三五重大科技：专项艾滋病和病毒性肝炎等重大传染病防治研究项目
北京市教委科技计划重点项目：固相模板引导的[2+2]光环合反应在四星烷合成中的应用研究
国家自然科学基金：离子液体应用于多面体烷的[2+2]光环合反应的研究
北京市自然科学基金重点项目：新型亚硝基脲的合成及抗肿瘤活性的研究
国家十二五科技重大专项：艾滋病和病毒性肝炎等重大传染病防治研究
北京市科研基地—科技创新平台—抗肿瘤创新药物的研制
企事业委托项目：新型药物色瑞替尼（Zykadia）的质量标准的建立
企事业委托项目：普拉克索合成工艺优化和质量标准的建立
企事业委托项目：新型EGFR抑制剂Osimertinib及其甲磺酸盐的合成、晶型及光稳定性研究
4.2 代表性成果
1.Shengquan Hu, Libin Yuan, Hong Yan, Zhigang Li, Design, synthesis and biological evaluation of Lenalidomide derivatives as tumor angiogenesis inhibitor, Bioorganic & Medicinal Chemistry Letters, 27 (2017) 4075–4081.
2.Hong-bo Tan, Xiu-qing Song, Hong Yan, Hong-xing Xin Synthesis, NMR analysis and X-ray crystal structure of 3-(2-naphthoyl)-6,12-diphenyl-3,9-diazatetraasterane, Journal of Molecular Structure, Volume 1129, 2017, 23-31.
3.Xiuqing Song; Hongbo Tan; Hong Yan; Yu ChangStructural analysis of N,N-diacyl-1,4-dihydropyrazine by variable-temperature NMR and DFT calculation，Journal of Molecular Structure, 2017, 1134, 606-610
4.Qidi Zhong; Qiangwen Fan; Hong Yan, Synthesis of 2,3-dihydropyrroles by photo rearrangement of Hantzsch 1,4-dihydropyridines with high diastereoselectivity, Tetrahedron Letters, 2017, 58, 1292–1295
5.Shunyi Wang, Wuji Sun, Qin Hu, Hong Yan * and Yi Zeng, Synthesis and evaluation of pyridinium polyoxometalates as anti-HIV-1 agents, Bioorganic & Medicinal Chemistry Letters, 2017, 27,2357–2359
6.闫红，樊强文，宋秀庆，谭洪波，李泽琳，曾毅, 2,5,8,11-四氮杂四星烷类化合物及其制备方法和应用, 授权，ZL2.8，**
7.闫红，王业明，胡盛全，6-腙基-8-氮杂嘌呤类化合物及其制备方法和应用，国家发明专利，1.6
8.闫红，赵志昌，胡盛全等. 一种AZD9291的制备方法.申请号：1.0.
9.Hongxing Xin, Xiaohe Zhu, Hong Yan,* and Xiuqing Song，Revelation from the Reaction of 1,4-Diazabutadiene with Perchloric Acid: An Approach to the Synthesis of Imidazolium Perchlorates，J. Heterocyclic Chem., 2016, 53, 1363–1366.
10.Zong-Shan Ma, Qiang-wen Fan, Hong Yan* and Da-Hai Yu, A FGFR-2 Inhibitor, Ki23057, Evaluated as a Novel VEGFR-2 Kinase Inhibitor, Journal of Pharmacy and Pharmaceutical Sciences, 2016, 5, 2322-0112.
11.Hong-bo Tan, Qi-di Zhong & Hong Yan*: Studies on the Photochemical Oxidation of N,N-Diacyl-1,4-dihydropyrazine Derivatives, Synthetic Communications, 2016, 46, 1-10.
12.闫红，孙武积，胡秦，艾萍，一种Keggin结构杂多酸含磷有机盐类化合物、制备方法和应用，中国发明专利，申请号，8.5，公开号，CN A
13.李泽林，曾毅，闫红，艾萍，胡秦，含氮的钨钛杂多酸盐类化合物、其制备方法和医药用途，中国发明专利，申请号，4.6
14.李泽林，曾毅，闫红，艾萍，胡秦，多酸化合物、其制备方法和医药用途，中国发明专利，申请号，6.9
15.Hongbo Tan, Xiuqing Song, Hong Yan. Photochemical Oxidation of N,N-bis-(tert-butoxycarbonyl)-1,4-Dihydropyrazine Derivatives. Heterocyclic Communications. 2015, 21, 83-88.
16.Yeming Wang, Hong Yan*, Chao Ma b , Dan Lu, Synthesis and anticancer activities of novel 8-azapurine carbocyclic nucleoside hydrazones, Bioorganic & Medicinal Chemistry Letters, 2015, 25, 4461–4463
17.Libin Yuan, Qiangwen Fan, Hong Yan & Xiu-Qing Song, Synthesis and Molecular Structure Characterization of Novel 1,6-Diazahexatrienes, Synthetic Communications 2015, 11(45), 1301-1310.
18.Wuji Sun, Yangye Jiang, Hong Yan*, and Xiuqing Song, Synthesis and Photoreaction of 2-Amino-3-cyano-4-aryl-4H-pyrans, Aust. J. Chem. 2015, 68, 273–281.
19.闫红，钟启迪，孙武积，宋秀庆，2,3-二氢吡咯类化合物、制备方法及其应用，发明专利，申请号2.0，公开号CN A
20.闫红；樊强文；高磊；任绘君, 一种硝基多面体烷化合物2,5,8,11-四硝基四氮杂四星烷及其制备方法, 2015/8/19, 北京, CN2.0.
21.闫红；樊强文；宋秀庆；谭洪波；李泽琳；曾毅, 2,5,8,11-四氮杂四星烷类化合物及其制备方法和应用, 2015/4/22, 北京, CN2.8.
22.闫红；王业明；钟启迪；任绘君；高磊, 一种替格瑞洛的制备方法, 2015/7/22, 北京, CN4.3.
23.闫红；王业明；孙武积；任绘君；樊强文, 一种卡格列净半水合物及其单晶的制备方法, 2015/7/1, 北京, CN6.9.
24.Ye, Jingrong; Lu, Hongyan; Su, Xueli; Xin, Ruolei; Bai, Lishi; Xu, Ke; Yu, Shuangqing; Feng, Xia; Yan, Hong*; He, Xiong; Zeng, Yi,Phylogenetic and Temporal Dynamics of Human Immunodeficiency Virus Type 1B in China: Four Types of B Strains Circulate in China, AIDS Research and Human Retroviruses, 30(9),920-926, 2014/9.
25.Xiaowei Duan, Hongxing Xin, Hong Yan. Design, Synthesis, and Biological Evaluation of 1,4-Diaryl-1,4-dihydropyrazines as Novel 11 β -HSD1 Inhibitors. Biological & Pharmaceutical Bulletin, 2014, 37(5): 840-846.
26.Liu, Peng; Xin, Hong-Xing; Song, Xiu-Qing; Yan, Hong, Structure Characterization of Novel 1,6-Diazahexiatrienes,Diethyl(E)-2,3-bis[(E)-(2-methyl-2-phenylhydrazin-1-ylidene)methyl]but-2-enedioate, Acta CrystallographicaSection E: Structure Reports Online,2014, 70, s o723.
27.Hongbo, Tan; Hongxing, Xin; Hong, Yan. SYNTHESIS AND PHOTOCHEMICAL PROPERTIES OF 2,4,6,-TRIARYL-4H-1,4-OXAZINES. HETEROCYCLES Vol. 89, No. 2 (2014), 359-373.
28.Xin, H.; Sun, W.; Yan, H.; Song, X., Photochemical ring contraction of 1-aryl-1,4-dihydropyrazine to 1-aryl-1H-imidazoleJournal of Photochemistry and Photobiology A: Chemistry, Volume(s) 267, 29-Jun-2013, Pages 49-54
29.H.L. ZHANG, X.H. ZHU, H. YAN* and X.Q. SONG, Highly Efficient, Selective,Ultrasound-Assisted Monohydrolysis of Polyhedral Diesters in a Co-solvent, Asian Journal of Chemistry; 25, 7351-7354, 2013.
30.Yanlan Liu, Hongbo Tan, Hong Yan* and Xiuqing Song, Design, synthesis and biological evaluation of 3,9-diazateraasteranes as novel matrilysin inhibitors Chem Biol Drug Des, 82, 567–578, 2013.
31.Xiao-He Zhu, Xin Zhang, Hong-Xing Xin, Hong Yan*, A Transformation of N-alkylated Anilines to N-Aryloxamates, Helvetica Chimica Acta,96, 1542-1547, 2013.
32.Hongxing Xin, Wuji Sun, Hong Yan?, Xiuqing Song Photochemical ring contraction of 1-aryl-1,4-dihydropyrazine to 1-aryl-1H-imidazole, Journal of Photochemistry and Photobiology A: Chemistry 267, 49-54, 2013.
33.Weipeng Li, Jian Wang, Hongxing Xin, Hong Yan*, Synthesis of 4H-1,4-oxazines as transthyretin amyloid fibril inhibitors, Organic & Biomolecular Chemistry, 11, 4546-4550, 2013.
34.Hongxing Xin, Xiaohe Zhu, Hong Yan*, Xiuqing Song, A Novel Photodimerization of 4-Aryl-4H-pyrans for Cage Compounds， Tetrahedron Letters, 54, 3325–**.
35.Jian Wang, Peng Li, Chengliang Ni, Hong Yan, Rugang Zhong, A one-pot synthesis of camphorquinone from camphor, Synthetic Communications, 43: 1543–1548, 2013.
36.Xiaohe Zhu, Weipeng Li, Hong Yan*, Rugang Zhong. Triplet Phenacylimidazoliums Catalyzed Photocycloaddition of 1,4-Dihydropyridines: an Experimental and Theoretical Study. Journal of Photochemistry & Photobiology A: Chemistry, 241: 13-20, 2012.
37.张宏雷, 朱晓鹤, 闫红*, 宋秀庆. 多面体烷氯乙基脲的合成新方法研究. 有机化学, 32: 344-348, 2012.
38.闫红，倪成良，朱晓鹤，宋秀庆，钟儒刚，高立方烷二酰胺类化合物及其应用，发明专利，ZL5.1, 2012.
39.Jiaojiao Duan, Xiaohui Song, Hong Yan*, and Xiuqing Song，Optimization of the Selective Monohydrolysis of Diethyl 4-Aryl-4H-pyran-3,5-dicarboxylates, Molecules, 16, 3845-3854, 2011.
40.Xiu-Qing Song, Cheng-Liang Ni, Hong Yan*, Hui-Qin Wang, Ru-Gang Zhong, Tetraethyl 2,4,8,10-tetramethyl-6,12-bis(4-fluorophenyl)-3,9-dioxapentacyclo[6.4.0.02,7.04,11.05,10]dodecane-1,5,7,11-tetracarboxylate: Synthesis, NMR analysis and X-ray crystal structure,Journal of Molecular Structure, 1006, 489–493, 2011.
41.Yu Qin, Hong F. Deng, Hong Yan*, Ru G. Zhong, Accurate nonlinear QSAR model for the antitumor activities of CENUs using neural networks, Journal of Molecular Graphics and Modelling，29 (2011) 826–833.
42.朱晓鹤，倪成良，宋秀庆，闫红*，钟儒刚，3,9-二氮杂四星烷类化合物的合成研究，有机化学, 30, 276-281, 2010.
43.C.L. Ni, X.H. Song, H. Yan*, X.Q. Song, R.G. Zhong, Improved synthesis of diethyl 2,6-dimethyl-4-aryl-4H-pyran-3,5-dicarboxylate under ultrasound irradiation, Ultrasonics Sonochemistry,17, 367-369, 2010.
44.Xiaohe Zhu, Yu Qin, Hong Yan*, Xiuqing Song, and Rugang Zhong, Synthesis, Biological Evaluation, and Molecular Modeling Studies of N-aryl-2-arylthioacetamides as Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors, Chem Biol Drug Des, 1-10, 2010.
45.闫红，倪成，王惠琴，温瑞兴, 钟儒刚, 李泽琳, 曾毅，3,9-二氧杂四星烷类化合物及其制备方法和应用，ZL2.0, 2010.
46.Zhong Qidi; Xue Yunzhou; Hong Yan*,Song Xiuqing; Zhong Rugang, Preparation of 4,7-Diphenyl-1,10-Phenanthroline-2,9-Dicarboxylic Acid Catalyzed by Iron(III)porphyrins with (Diacetoxyiodo)benzene, Bioorganic & Medicinal Chemistry Letters, 20, 5532–5535, 2010.
47.X.H. Zhu, C.L. Ni, H. Yan*, R.G. Zhong, Synthesis and X-ray Crystallographic Analysis of 1,4-dihydropyridine Photodimerization, J. Photopolym. Sci. Technol, 22, 379-384, 2009.

五、联系方式等信息
E-mail:hongyan@bjut.edu.cn