一、基本情况
胡利明，1963年9月生，博士，教授，博士生导师。分别于1985年和1994年在华中师范大学获得理学学士和硕士学位；2001年在武汉大学获得理学博士学位。先后在武汉教育学院和华中师范大学从事教学和科研工作；2002年进入厦门大学福建省化学生物学重点实验室从事博士后研究；2004年进入北京工业大学，现为北京工业大学生命科学与生物工程学院教授。
二、主要研究方向
（1）药物合成方法学研究与新技术应用；
（2）计算机辅助药物设计与虚拟筛选；
（3）蛋白质与配体的相互作用与识别以及构效关系的研究；
（4）具有生物活性的有机磷化学研究；
（5）天然药物中有效成分的提取、鉴定和活性研究
三、在研项目（主持，2010年）
（1）国家重大科学研究计划项目(2009.1-2013.12)：载药纳米颗粒的药效学、生物利用度及其机理研究；
（2）北京市人才强教项目：HIV与靶细胞融合过程的小分子抑制剂研究；
（3）北京市基金(2010.1-2012.12)：以gp41为靶标的抗HIV-1药物先导体研究。
四、研究成果
自2001年以来，主持和参与研究项目二十多项，包括国家重大科学研究计划项目、国家科技攻关项目、国家自然科学基金项目、教育部重点科技项目、博士后基金项目、北京市教委科技项目、北京市人才强教项目、北京市基金项目、湖北省重点科技项目、福建省重大科技项目、福建省重点科技项目和福建省自然科学基金项目等；获得湖北省科技进步二等奖（1999）和北京市中青年骨干教师；在各级、类刊物中发表研究性学术论文100余篇，其中有35篇被SCI收录；授权专利6件（其中美国专利1项）；作为主要研究者获得国家三类新药证书1项、国家重点新产品证书1项、国家食品药品监督管理局原料药和制剂注册批件各1件。
五、近三年来发表的学术论文
1. Xiaowei Ma, Dongliang Wang,Yan Wu, Rodney J. Y. Ho, Lee Jia, Peixuan Guo,Liming Hu,Gengmei Xing,Yi Zeng, Xing-Jie Liang, AIDS Treatment with Novel Anti-HIV Compounds Improved
by Nanotechnology,The AAPS Journal, 2010,12(3), 272-278
2. Cheng-Chu Zeng,Da-Wei Ping,Li-Ming Hu, Xiu-Qing Song, Ru-Gang Zhong, Anodic oxidation of catechols in the presence of a-oxoketene N,N-acetals with a tetrahydropyrimidine ring: selective a-arylation reaction,Organic & Biomolecular Chemistry,2010, 8: 2465–2472
3. Leifu Yang, Xuemei Xu, Yali Huang, Bin Zhang, Chengchu Zeng, Hongqiu He, Cunxin Wang,Liming Hu, Synthesis of polyhydroxylated aromatics having amidation of piperazine
nitrogen as HIV-1 integrase inhibitor,Bioorganic & Medicinal Chemistry Letters, 2010,20:5469–5471
4.Lin Yang , Liqiang Chen , Rong Zeng , Chao Li , Renzhong Qiao ,Liming Hu, Zelin Li, Synthesis, nanosizing and in vitro drug release of a novel anti-HIV polymeric prodrug: Chitosan-O-isopropyl-5- O-d4T monophosphate,Bioorganic & Medicinal Chemistry,2010,18:117-123
5.Jian J. Tan, Xiao J. Cong,Li M. Hu, Cun X. Wang,Lee Jia and Xing-Jie Liang, Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection,Drug Discovery Today,2010, 15( 5/6), 186-197
6.LUO Zai-gang, ZENG Cheng-chu, WANG Fang, HE Hong-qiu, WANG Cun-xin, DU Hong- guang ,HU Li-ming, Synthesis and Biological Activities of Quinoline Derivatives as HIV-1 Integrase Inhibitors,CHEM. RES. CHINESE UNIVERSITIES，2009, 25(6), 841-845
7.Zeng CC, Ping DW, Xu YS,Hu,LMet al.,A Facile Synthesis of alpha-Aryl alpha-Oxo- heterocyclic Ketene N,N-Acetals Bearing an Electron-Rich Catechol Subunit-An Electrochemical Oxidative Approach,EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2009, 33: 5832-5840
8.Yang DS, Liu HX, Yang HJ,Hu,LMet al.Copper-Catalyzed Synthesis of 1,2,4-Benzothiadia- zine 1,1-Dioxide Derivatives by Coupling of 2-Halobenzenesulfonamides with Amidines，ADVANCED SYNTHESIS & CATALYSIS, 2009,351(11-12):1999-2004
9.Zeng CC, Liu FJ, Ping DW,Hu,LMet al.One-Pot Electrochemical Synthesis of Fused Indole Derivatives Containing Active Hydroxyl Groups in Aqueous Medium,JOURNAL OF ORGANIC CHEMISTRY,2009, 74(16): 6386-6389
10.Luo ZG, Zeng CC, Yang DS,Hu,LMet al.Electrospray Ionization Mass Spectra of Dipeptide Derivatives，CHINESE JOURNAL OF CHEMISTRY,2009,27(7):1333-1338
11.Zeng J, Lu XH, Zeng CC,Hu,LMet al.,Design, Synthesis and Anti-HIV Integrase Evaluation of 1,2,3-Triazol-4-yl-substituted 1,4-Dihydro-4-oxo-1,5-napthyridine-3-carboxylic Acids,CHINESE JOURNAL OF CHEMISTRY, 2009, 27( 5): 953-962
12.Zeng CC, Liu FJ, Ping DW,Hu,LMet al.,Electrochemical synthesis of 1,3,4-thiadiazol-2- ylthio-substituted catechols in aqueous medium,TETRAHEDRON, 2009, 65(23): 4505-4512
13.Luo ZG, Zeng CC, Yang LF,Hu,LMet al.,Synthesis of 6-sulfamoyl-4-oxoquinoline-3- carboxylic acid derivatives as integrase antagonists with anti-HIV activity,CHINESE CHEMICAL LETTERS,2009, 20( 7): 789-792
14.Yang DS, Fu H,Hu LM, et al.,Environmentally Friendly Iron-Catalyzed Cascade Synthesis of 1,2,4-Benzothiadiazine 1,1-Dioxide and Quinazolinone Derivatives,JOURNAL OF COMBINATORIAL CHEMISTRY, 2009,11( 4): 653-657
15.Yang,L；Zeng,R；Li,C；Li,G；Qiao,RZ；Hu,LM；Li,ZL, Novelsynthesisandinvitrodrugreleaseofpolymericprodrug:Chitosan-O-isopropyl-5'-O-d4Tmonophosphateconjugate，BIOORGANIC&MEDICINALCHEMISTRYLETTERS,2009，19(9):2566-2569
16.XuYS,ZengCC,Jiao,ZG,HuLM, ZhongRG, Design,SynthesisandAnti-HIVIntegraseEvaluationof 4-Oxo-4H-quinolizine-3- carboxylicAcidDerivatives，MOLECULES，2009，14(2):868-883
17.Yang DS, FuH,HuLM,Jiang YY, Zhao,YF, Copper-catalyzedsynthesisofbenzimidazoles viacascadereactionsofo-haloacetanilidederivativeswithamidinehydrochlorides,JOURNALOFORGANICCHEMISTRY, 2008,73(19):7841-7844
18.HuLM,Wu J,LiXP, XuHS, Investigationofplantsystemicorganoselenocompounds. V.Effectsof thederivativesofselenomorpholineontheseleniumcontentofgarlic,JOURNALOFPLANTNUTRITION, 2008,31(9):1570-1577
19.WangF,HuLM, Li,XP, XuXM,DuHG, SynthesisofO,O-dialkyl 2-oxo-2-(4-(selenomorpho- linosulfonyl)phenylamino) ethylphosphonate,PHOSPHORUSSULFURANDSILICONANDTHERELATEDELEMENTS，2008,183(2-3):610-616

六、目前在读博士生1名，在读硕士生8名
联系方式：北京市朝阳区平乐园100号北京工业大学生命科学院(100124)
E-mail: huliming@bjut.edu.cn
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