教师姓名：杜大明
出生年月：1967 年 11 月 所在学科：制药与精细化工
职 称：教授，博士生导师联系电话：010-**
电子邮箱：dudm@bit.edu.cn
教育经历
1992 年 9 月?1995 年 6 月，南开大学有机化学专业博士研究生
1989 年 9 月?1992 年 7 月，南开大学有机化学专业硕士研究生
1985 年 9 月?1989 年 7 月，郑州大学化学专业本科
工作经历
2016 年?目前， 北京理工大学化学与化工学院，教授，博士生导师
2008 年?2016 年，北京理工大学化工与环境学院，教授，博士生导师
2001 年?2008 年，北京大学化学与分子工程学院，副教授，博士生导师
1999 年?2001 年，北京大学化学与分子工程学院，博士后
1995 年?1999 年，山东大学化学学院，先后任讲师、副教授
（其间：香港中文大学和香港科技大学访问学者和博士后研究）
研究方向
新型手性配体及金属络合物催化剂、有机小分子催化剂的设计合成与不对称催化反应研究, 发展高效不对称合成新方法。
具有生物活性杂环化合物和药物中间体合成。
研究成果
近年开展新型手性配体和有机小分子催化剂的设计合成及其不对称催化反应研究，设计合成几个系列新型 C2 对称的手性双噁唑啉、双噻唑啉和双咪唑啉配体、C3 对称的新型手性三酰氨类配体和新型有机磷酸、方酰胺等小分子催化剂。研究这些新手性配体金属络合物催化剂和有机小分子催化剂在不对称 Michael 加成反应、Friedel-Crafts烷基化反应、Henry 反应、Mannich 反应、炔基化、Strecker 反应、亲电氟化反应、硼烷
还原、转移氢化和 Michael/Michael 加成串联等多种有机反应中的催化反应活性及机理，发展了一些高效、高选择性的不对称催化合成重要手性砌块和生物活性杂环化合物的新方法, 取得了一系列富有特色的重要成果。研究成果已在 J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett., Chem. Commun., Adv. Synth. Catal., J. Org. Chem.等国际重要期刊上发表，引起了国内外同行的广泛关注和引用。目前已在国内外重要学术期刊上发表学术论文 180 余篇，SCI 收录 170 余篇，他引 3400 余次，H 指数为 36。已获授权美国、英国和中国发明专利十余件。2007 年入选教育部新世纪优秀人才支持计划；2008 年入选北京理工大学杰出中青年教师支持计划。2005 年获得第八届北京青年优秀科技论文评选二等奖；2007 年获得 Tetrahedron: Asymmetry Most Cited Paper 2004-2007 Award；2009年获得 Thieme Journal Award。
代表性论文
Bo-Liang Zhao, Da-Ming Du*. Catalytic asymmetric Mannich/cyclization of 2-isothiocyanato-1-indanones: An approach to the synthesis of bispirocyclic indanone- thioimidazolidine-oxindoles. Organic Letters, 2018, 20(13), 3797-3800.
Bing-Yu Li, Da-Ming Du*. Chiral squaramide-catalyzed asymmetric Mannich reactions for synthesis of fluorinated 3,3’-bisoxindoles. Advanced Synthesis & Catalysis, 2018, 360(16), 3164-3170.
Zhihao Cui, Da-Ming Du*. Decarboxylative synthesis of functionalized oxindoles via an
iron-initiated radical chain process and application in constructing diverse fused-indoline heterocycles. Advanced Synthesis & Catalysis, 2018, 360(1), 93-99.
Zhihao Cui, Da-Ming Du*. FeCl2-catalyzed decarboxylative radical alkylation/ cyclization of cinnamamides: access to dihydroquinolinone and pyrrolo[1,2-a]indole analogues. Journal of Organic Chemistry, 2018, 83(9), 5149-5159.
Ye Lin, Bo-Liang Zhao, Da-Ming Du*. Organocatalytic asymmetric synthesis of 3,3’-pyrrolidinyl-bispirooxindoles via Michael/N-hemiketalization cascade reaction between 3-aminooxindoles and isatin-derived ?,?-Unsaturated ?-Keto Esters. Journal of Organic Chemistry, 2018, 83(15), 7741-7750.
Yong-Xing Song, Da-Ming Du*. Asymmetric construction of bispiro[oxindole-pyrrolidine-rhodanine]s via squaramide-catalyzed domino Michael/ Mannich [3+2] cycloaddition of rhodanine derivatives with N-(2,2,2-trifluoro- ethyl)isatin ketimines. Journal of Organic Chemistry, 2018, 83(16), 9278-9290.
Bo-Liang Zhao, Da-Ming Du*. Enantioselective squaramide-catalyzed trifluoromethyl-
thiolation-sulfur-Michael/aldol cascade reaction: One-pot synthesis of CF3S-containing spiro cyclopentanone-thiochromanes. Organic Letters, 2017, 19(5), 1036-1039.
Bo-Liang Zhao, Da-Ming Du* Organocatalytic cascade Michael/Michael reaction for the asymmetric synthesis of spirooxindoles containing five contiguous stereocenters.
Chemical Communications, 2016, 52(36), 6162-6165.
Zhihao Cui, Da-Ming Du*. Enantioselective synthesis of ?-hydrazino alcohols using alcohols and N-Boc-hydrazine as substrates. Organic Letters, 2016, 18(21), 5616-5619.
Bo-Liang Zhao, Da-Ming Du*. Squaramide-catalyzed enantioselective cascade approach to bispirooxindoles with multiple stereocenters. Advanced Synthesis & Catalysis, 2016, 358(24), 3992-3998.
Jun-Hua Li, Zhihao Cui, Da-Ming Du*. Diastereo- and enantioselective construction of cyclohexanone-fused spirospyrazolones containing four consecutive stereocenters through asymmetric sequential reactions. Organic Chemistry Frontiers, 2016, 3(9), 1087- 1090.
Jun-Hua Li, Da-Ming Du*. Phosphine-catalyzed cascade reaction of unsaturated pyrazolones with alkyne derivatives: Efficient synthesis of pyrano[2,3-c]pyrazoles and spiro-cyclopentanone-pyrazolones. Advanced Synthesis & Catalysis, 2015, 357(18), 3986
-3994.
Jiahuan Peng, Bo-Liang Zhao, Da-Ming Du*. A combination of metal and organocatalysis: Highly diastereo- and enantioselective construction of fluorinated 2-aminocyclopenta[b]pyran derivatives. Advanced Synthesis & Catalysis, 2015, 357(16- 17), 3639-3647.
Jun-Hua Li, Ting-Fan Feng, Da-Ming Du*. Construction of spirocyclopropane-linked heterocycles containing both pyrazolones and oxindoles through Michael/alkylation cascade reaction. Journal of Organic Chemistry, 2015, 80(22), 11369-11377.
Wen Yang, Da-Ming Du*. Cinchona-based squaramide-catalysed cascade
aza-Michael-Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines. Chemical Communications, 2013, 49(78), 8842-
8844.
Wen Yang, Yi Yang, Da-Ming Du*. Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/Michael addition via dynamic kinetic resolution: access to highly functionalized chromans with three contiguous stereocenters. Organic Letters, 2013, 15(6), 1190-1193.
Wen Yang, Hai-Xiao He, Yu Gao, Da-Ming Du*. Organocatalytic enantioselective cascade aza-Michael/Michael addition for the synthesis of highly functionalized tetrahydroquinolines and tetrahydrochromanoquinolines. Advanced Synthesis & Catalysis, 2013, 355(18), 3670-3678.
Hai-Xiao He, Wen Yang, Da-Ming Du*. Enantioselective aza-Henry reaction of imines bearing a benzothiazole moiety catalyzed by a cinchona-based squaramide. Advanced Synthesis & Catalysis, 2013, 355(6), 1137-1148.
Wen Yang, Da-Ming Du*. Chiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes. Chemical Communications, 2011, 47(47), 12706-12708.
Wen Yang, Da-Ming Du*. Chiral squaramide-catalyzed highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes. Advanced Synthesis &
Catalysis, 2011, 353(8), 1241-1246.
Wen Yang, Da-Ming Du*. Highly enantioselective Michael addition of nitroalkanes to chalcones using chiral squaramides as hydrogen bonding organocatalysts. Organic Letters, 2010, 12(23), 5450-5453.
Han Liu, Da-Ming Du*. Development of diphenylamine-linked bis(imidazoline) ligands and their application inasymmetric Friedel-Crafts alkylation of indole derivatives with nitroalkenes. Advanced Synthesis & Catalysis, 2010, 352(7), 1113-1118.
Qun-Sheng Guo, Da-Ming Du*, Jiaxi Xu. The development of new double axially chiral phosphoric acids and their catalytic asymmetric transfer hydrogenation of quinolines. Angewandte Chemie, International Edition, 2008, 47(4), 759-762.
Wen-Ming Zhou, Han Liu, Da-Ming Du*. Organocatalytic highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes. Organic Letters, 2008, 10(13), 2817–2820.
Han Liu, Jiaxi Xu, Da-Ming Du*. Asymmetric Friedel-Crafts alkylation of methoxyfuran with nitroalkenes catalyzed by diphenylamine-tethered bis(oxazoline)-Zn(II) complexes. Organic Letters, 2007, 9(23), 4725-4728.
Shao-Feng Lu, Da-Ming Du*, Jiaxi Xu, Shi-Wei Zhang. Asymmetric conjugate addition of nitroalkanes to nitroalkenes catalyzed by C2-symmetric tridentate bis(oxazoline) and bis(thiazoline) zinc complexes. Journal of the American Chemical Society, 2006, 128(23), 7418-7419.
Shao-Feng Lu, Da-Ming Du*, Jiaxi Xu. Enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II) complex. Organic Letters, 2006, 8(10), 2115-2118.
Da-Ming Du*, Tao Fang, Jiaxi Xu, Shi-Wei Zhang. Structurally well-defined, recoverable C3-symmetric tris(?-hydroxy phosphoramide)-catalyzed enantioselective borane reduction of ketones. Organic Letters, 2006, 8(7), 1327-1330.
Tao Fang, Da-Ming Du,* Shao-Feng Lu, Jiaxi Xu*. Synthesis of C3-Symmetric tris(?-hydroxy amide) ligands and their Ti(IV) complex-catalyzed enantioselective alkynylation of aldehydes. Organic Letters, 2005, 7(11), 2081-2084.
Da-Ming Du,* Shao-Feng Lu, Tao Fang, Jiaxi Xu*. Asymmetric Henry reactioncatalyzed by C2-symmetric tridentate bis(oxazoline) and bis(thiazoline) complexes: metal- controlled reversal of enantioselectivity. Journal of Organic Chemistry, 2005, 70(9), 3712-3715.
科研项目
方酰胺催化不对称加成与串联反应合成杂环化合物研究. (国家自然科学基金面上项目，No.**, 项目负责人)
模块组装合成多齿手性配体及在不对称催化反应中的应用研究. (国家自然科学基金面上项目，No.**, 项目负责人)
手性方酰胺催化不对称串联反应合成含氮杂环化合物研究. (元素有机化学国家重点实验室基金项目，No.201406, 项目负责人)
新型手性配体及催化剂设计合成与高效不对称催化研究. (北京理工大学科技创新计划重大项目培育专项计划, No.2011CX01008, 项目负责人)
三齿手性配体的合成与不对称催化反应研究. ( 国家自然科学基金面上项目，
No.**, 项目负责人)
新型 C3 对称性手性配体的合成及其在不对称催化反应中的应用. (国家自然科学基金面上项目，No.**, 项目负责人)
教育部新世纪优秀人才支持计划. (国家教育部人才项目，No. NCET-07-0011, 项目负责人)
有机合成化学与方法学. (国家自然科学基金会创新群体项目，No. **, 项目参加人).
新杂环手性配体的合成与不对称催化反应研究. (国家自然科学基金面上项目，
No.**, 项目负责人)
新手性双噁唑啉催化剂的设计合成与不对称催化反应研究. (国家自然科学基金面上项目，No.**, 项目负责人)
手性磷酰胺主体化合物的合成、分子识别及应用基础研究. (国家自然科学基金面上项目，No. **, 项目负责人)
学术兼职
欧洲化学出版协会期刊 ChemistrySelect 编委。国家和北京市科技奖励评审专家、国家自然基金委同行评议专家。国内外重要期刊 Angew. Chem. Int. Ed.、J. Am. Chem. Soc、 Nat. Commun.、Chem. Comm.、Adv. Synth. Catal.、Org. Lett.、J. Org. Chem.、Eur. J. Org. Chem.、Chem-Eur. J.、Chem-Asian J.、RSC Adv.、Catal. Sci. Tech.、ACS Sustain Chem. Eng.、 Org. Biomol. Chem.、New J. Chem.、Tetrahedron、Tetrahedron Lett.等审稿专家。
