冯旭东
个人概况
特别副研究员, 博士生导师
招生专业：化学工程与技术（生物化工），制药工程，生物工程
出生年月：1985 年 5 月籍 贯：河北省
联系方式
电 话 ：010-**
电子邮件：xd.feng@bit.edu.cn
工作单位：北京理工大学化学与化工学院工作地点：中关村校区 5 号教学楼
教育经历
2010/04 – 2014/06，新西兰奥克兰大学，“化学与材料工程”博士
2007/09 – 2009/06，天津大学，化工学院，“生物化工”硕士
2003/09 – 2007/07，河北工业大学，化工学院，“生物工程”学士
工作经历
2017/12– 至今， 北京理工大学，化学与化工学院，特别副研究员
2016/10 – 2017/11，北京理工大学，生命学院，特别副研究员
2014/07 – 2016/09，北京理工大学，生命学院，师资博士后
研究方向：酶工程、蛋白质工程、合成生物学
以植物天然产物合成过程中关键酶的挖掘、工程化改造及应用为主要研究内容，利用蛋白质结构解析结合计算机模拟技术，研究酶的结构和功能之间的构效关系；通过蛋白质工程手段对酶的稳定性、活性、底物特异性等方面进行分子改造，获得满足工业化需求的高效酶制剂；通过构建无细胞催化体系或微生物细胞工厂高效合成植物天然产物，利用生化反应工程及代谢工程的策略对生物转化过程进行强化，为实现其产业化提供理论指导。
在研项目
国家自然科学基金青年科学基金项目，**，人工设计糖基化调控酶耐热性的研究，2016/01-2018/12，21 万元，主持。
国家自然科学基金重点基金项目，**，微生物合成萜烯化合物过程中的跨膜转运与代谢传质强化，2018/01-2022/12，320 万元，参与。
发表文章
Yujia Zhao, Bo Lv, Xudong Feng*, Chun Li*, Perspective on biotransformation and de novo biosynthesis of licorice constituents, Journal of Agricultural and Food Chemistry, 2017, 65: 11147-11156.
Xiaochen Liu, Liang Zhang, Xudong Feng, Bo Lv*, Chun Li, Biosynthesis of glycyrrhetinic acid-3-O-monoglucose using glycosyltransferase UGT73C11 from Barbarea vulgaris, Industrial & Engineering Chemistry Research, 2017, 56: 14949- 14958.
Bo Lv, Hanli Sun, Shen Huang, Xudong Feng, Tao Jiang, Chun Li*. Structure-guided
engineering of the substrate specificity of a fungal β-glucuronidase toward triterpenoid saponins. Journal of Biological Chemistry, 2018, 293, 433-443.
Xudong Feng, Heng Tang, Beijia Han, Bo Lv, Chun Li*. Engineering the thermostability of β-glucuronidase from Penicillium purpurogenum Li-3 by loop transplant. Applied Microbiology and Biotechnology, 2016. 100(23): 9955-9966.
Xudong Feng, Heng Tang, Beijia Han, Bo Lv, Chun Li*. Enhancing the thermostability of β-glucuronidase by rationally redesigning the catalytic domain
based on sequence alignment strategy. Industrial & Engineering Chemistry Research, 2016, 55, 5474?5483.
Bo Lv, Xiaogang Yang, Xudong Feng*, Chun Li. Enhanced production of glycyrrhetic acid 3-O-mono-β-D- glucuronide by fed-batch fermentation using pH and dissolved oxygen as feedback parameters. Chinese Journal of Chemical Engineering, 2016, 24(4): 506-512.
Haiyang Jia, Xiangying Sun, Huan Sun, Chenyi Li, Yunqian Wang, Xudong Feng, Chun
Li*. Intelligent microbial heat-regulating engine (IMHeRE) for improved thermo- robustness and efficiency of bioconversion. ACS Synthetic Biology, 2016, 5(4): 321- 320.
Zhe Li, Xiaoxiao Guo, Xudong Feng, Chun Li*. An environment friendly and efficient process for xylitol bioconversion from enzymatic corncob hydrolysate by adapted candida tropicalis. Chemical Engineering Journal, 2015. 263, 249-256.
Xiaoyan Wang, Yanli Liu, Chao Wang, Xudong Feng*, Chun Li*. Properties and structures of beta-glucuronidases with different transformation types of glycyrrhizin. RSC Advances, 2015. 5(84): 68345-68350.
Shen Huang, Xudong Feng*, Chun Li. Enhanced production of beta-glucuronidase from Penicillium purpurogenum Li-3 by optimizing fermentation and downstream processes. Frontiers of Chemical Science and Engineering, 2015. 9(4): 501-510.
Lifeng Qiao, Bo Lv, Xudong Feng, Chun Li*. A new application of aptamer: One-step purification and immobilization of enzyme from cell lysates for biocatalysis. Journal of Biotechnology, 2015. 203, 68-76.
Xudong Feng, Chun Li*. The improvement of enzyme properties and its catalytic engineering strategy. Progress in Chemistry, 2015. 27(11): 1649-1657.
Xudong Feng, DA Patterson, M Balaban, EAC Emanuelsson*. Increasing reaction rate and conversion in the spinning cloth disc reactor: Investigating the effect of using multiple enzyme immobilized cloths. Chemical Engineering Journal, 2014. 255: 356-364.
Xudong Feng, DA Patterson, M Balaban, EAC Emanuelsson*. Characterization of liquid flow in the spinning cloth disc reactor: residence time distribution, visual study and modeling, Chemical Engineering Journal, 2014. 235: 356-367.
Xudong Feng, DA Patterson, M Balaban, EAC Emanuelsson*. Enabling the utilization of wool as an enzyme support: enhancing the activity and stability of lipase immobilized onto woolen cloth, Colloids and Surfaces B: Biointerfaces, 2013. 102: 526-533.
Xudong Feng, DA Patterson, M Balaban, EAC Emanuelsson*. Characterization of tributyrin hydrolysis by immobilized lipase on woolen cloth using conventional batch and novel spinning cloth disc reactors, Chemical Engineering Research and Design, 2013. 91(9): 1684-1692.
Xudong Feng, DA Patterson, M Balaban, G Fauconnier, EAC Emanuelsson*. The spinning cloth disc reactor for immobilized enzymes: A new process intensification technology for enzymatic reactions, Chemical Engineering Journal, 2013. 221: 407- 417.
