简介
研究方向
发表论著
承担科研项目
项目组情况
招生信息

刘欣(LIU Xin)
博士生导师，研究员
E-Mail：liuxin@big.ac.cn
研究领域：遗传学,基因组学
导师简介：学习经历：
1988年9月-1993年7月，山东医科大学，临床医学专业，医学学士学位
1997年9月-2002年2月，美国约翰霍普金斯大学，遗传流行病学专业，博士学位
工作经历：
2015年1月-至今 中国科学院北京基因组研究所 研究员 博士生导师
2007年1月-2015年1月 美国西北大学 儿科系助理教授
2004年2月-2006年12月 美国加州大学旧金山分校 遗传流行病学专业博士后
2002年2月-2003年12月 美国约翰霍普金斯大学布隆博格公共卫生学院 遗传流行病学专业博士后
1993年9月-1995年11月 北京工人疗养院 内科医生

学术兼职：

获奖及荣誉：


人类复杂疾病的遗传和表观遗传研究

近期主要学术成果：
代表论著（*: corresponding author）:
1. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia.
Blood. 131(20):2256-2261,2018
Zhang Y, Gao Y, Zhang H, Zhang J, He F, Hnízda A, Qian M, Liu X, Gocho Y, Pui CH, Cheng T, Wang Q, Yang JJ*, Zhu X*, Liu X*.
2. Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy.
Medicine. 97(9):e0043,2018
Liu X*, Hong X, Tsai HJ, Mestan KK, Shi M, Kefi A, Hao K, Chen Q, Wang G, Caruso D, Geng H, Gao Y, He J, Kumar R, Wang H, Yu Y, Bartell T, Tan XD, Schleimer RP, Weeks DE, Pongracic JA, Wang X.
3. Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth.
Nat Commun. 8:15608, 2017
Hong X, Hao K, Ji H, Peng S, Sherwood B, Di Narzo A, Tsai HJ, Liu X, Burd I, Wang G, Ji Y, Caruso D, Mao G, Bartell TR, Zhang Z, Pearson C, Heffner L, Cerda S, Beaty TH, Fallin MD, Lee-Parritz A, Zuckerman B, Weeks DE, Wang X.
4. Genome-wide DNA Methylation Associations with Spontaneous Preterm Birth in US Blacks: Findings in Maternal and Cord Blood Samples. Epigenetics. (Epub ahead of print)
Hong X, Sherwood B, Ladd-Acosta C, Peng S, Ji H, Hao K, Burd I, Bartell TR, Wang G, Tsai HJ, Liu X, Ji Y, Wahl A, Caruso D, Lee-Parritz A, Zuckerman B, Wang X.
5. Racial Disparity in the Associations of Cotinine with Insulin Secretion: Data from the National Health and Nutrition Examination Survey, 2007-2012.
Plos One. 11(12):e**, 2016
Liu R*, Zheng Z, Du J, Christoffel KK, Liu X*.
6. Genome-wide Association Study of Food Allergy Identifies Peanut Allergy-Specific Susceptibility Loci and Evidence of Epigenetic Mediation in U.S. Children of European Ancestry.
Nat Commun. 24;6:6304, 2015
Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker SO, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X.
7. Maternal Pre-conception Body Mass Index and Offspring Cord Blood DNA Methylation: Exploration of Early Life Origins of Disease.
Environ Mol Mutagen. 55(3):223-30, 2014
Liu X*, Chen Q, Tsai HJ, Wang GY, Hong XM, Zhou Y, Zhang CL, Liu CY, Liu R, Wang HJ, Zhang SC, Yu YX, Mestan K, Pearson P, Otlans P, Zuckerman P, Wang XB.
8. Blood methylomics in response to arsenic exposure in a low-exposed US population.
J Expo Sci Environ Epidemiol. 24(2):145-9, 2014
Liu X, Zheng YN, Zhang W, Zhang X, LIoyd-Jones DM, Baccarelli AA, Ning HY, Fornage M, He K, Liu K, Hou LF.
9. Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization.
Pediatr Res. 74(3):321-6, 2013
Liu X*, Arguelles L, Zhou Y, Wang GY, Chen Q, Tsai HJ, Hong XM, Liu R, Price HE, Pearson C, Apollon S, Cruz N, Schleimer R, Langman CB, Pongracic J, Wang XB.
10. Microsomal epoxide hydrolase (EPHX1) polymorphisms are associated with aberrant promoter methylation of ERCC3 and hematotoxicity in benzene-exposed workers.
Environ Mol Mutagen. 54(6): 397-405, 2013
Xing CH, Chen Q, Li GL, Zhang LY, Zheng M, Zou ZY, Hou LF, Wang QF, Liu X*, Guo XB*.
11. Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life.
Epigenetics. 7(6): 594-605, 2012
Wang D*, Liu X*, Zhou Y, Xie H, Hong XM, Tsai HJ, Wang GY, Liu R, Wang XB.
12. Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a U.S. urban black population.
Hum Genet. 131(3):341-51, 2012
Liu X*, Wang GY, Hong XM, Tsai HJ, Liu R, Zhang SC, Wang HJ, Pearson C, Ortiz K, Wang D, Hirsch E, Zuckerman B, Wang XB.
13. A population-based twin study on sleep duration and body composition.
Obesity. 20(1):192-9, 2012
Liu R, Liu X, Arguelles L, Patwari, PP, Zee PC, Chervin RD, Ouyang F, Christoffel KK, Zhang SC, Wang GY, Xu X, Wang XB.
14.Association between short sleep duration and the risk of sensitization to food and aero allergens in Rural Chinese Adolescents.
Clin Exp Allergy. 41(4):547-55, 2011
Zhang S, Liu X (Co-first author), Kim JS, Ouyang F, Wang B, Li Z, Tang G, Liu X, Yang J, Xu X, Pongracic JA, Wang X.
15. Fine mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.
Prostate. 71(7): 682-685, 2011
Liu X, Cheng I, Plummer SJ, Suarez B, Casey G, Catalona WJ, Witte JS.
16. Gene-Vitamin D interactions on food sensitization: a prospective birth cohort study.
Allergy. 66(11):1442-8, 2011
Liu X*, Wang GY, Hong XM, Wang D, Tsai HJ, Zhang SC, Arguelles L, Kumar R, Wang HJ, Liu R, Zhou Y, Pearson C, Ortiz K, Schleimer R, Holt P, Pongracic J, Price HE, Langman C, Wang XB.
17. Genetic and Environmental Contributions to Allergen Sensitization in a Chinese Twin Study.
Clin Exp Allergy. 39(7):991-8, 2009
Liu X*, Zhang SC, Tsai HJ, Hong XM, Wang BY, Fang YP, Liu X, Pongracic J, Wang X.
18. Trans Fatty Acid Intake and Increased Risk of Advanced Prostate Cancer: Modification by RNASEL R462Q Variant.
Carcinogenesis. 28:1232-6, 2007
Liu X*, Schumacher FR, Plummer SJ, Jorgenson E, Casey G, Witte JS*.
19. Multiple Essential Hypertension Susceptibility Genes On Chromosome 1q.
Am J Hum Genet. 80: 253-264, 2007
Chang YP, Liu X, Kim J, Ikeda MA, Layton M, Weder A, Cooper R, Kardia S, Rao DC, Hunt S, Luke A, Boerwinkle E, Chakravarti A.
20. Nonsteroidal Anti-inflammatory Drugs and Decreased Risk of Advanced Prostate Cancer: Modification by Lymphotoxin Alpha.
Am J Epidemiol. 164:984-989, 2006
Liu X, Plummer SJ, Nock NL, Casey G, Witte JS.
21. Hierarchical modeling in association studies of multiple phenotypes.
BMC Genet. 6(S1):S104, 2005
Liu X, Jorgenson E, Witte JS.
22. Genetic dissection methods: designs used for tests of gene-environment interaction.
Curr Opin Genet Dev. 14:241-245, 2004
Liu X, Fallin MD, Kao WH.
23. Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study.
J Allergy Clin Immunol. 113:489-95, 2004
Liu X, Beaty TH, Deindl P, Huang SK, Lau S, Sommerfeld C, Fallin D, Kao WH, Wahn U, Nickel R.


1.国家自然科学基金面上项目，儿童噬血细胞综合征的遗传突变研究，2016-2019，在研，项目负责人；
2.中科院重点部署，中国人群精准医学研究计划/职业人群队列建立及精准医学研究， 2015-2018，在研，项目负责人。


项目组简介:
　　复杂性状和疾病（例如，体脂百分比、血脂、糖尿病、恶性肿瘤等）是诸多遗传和非遗传因素以及他们之间长期相互作用的结果。但是目前对于这些复杂表型决定因素的认知有限，从而阻碍了疾病的早期精准预测和治疗。研究组将在自然人群、临床患者和疾病家系中进行基因组和表观基因组等组学的分析，发现导致疾病发生、影响药物敏感性的遗传和表观遗传变异等分子标记物，探索基因和环境相互作用与复杂性状/疾病风险的关联性。为疾病易感人群的发现和疾病早期诊断、预防和治疗提供理论依据, 从而为最终实现精准医疗奠定基础。
研究组目前的主要研究工作：
　　1．中科院人群队列建立及精准医学研究
　　2．儿童噬血细胞综合征的遗传突变研究
　　3．家族性多发肿瘤的遗传变异研究
　　4．家族性嗜酸性粒细胞增多症的遗传变异研究
　　5. 白血病药物治疗的遗传及表观遗传机制的研究
临床合作单位：
　　中国医学科学院天津血液病医院
　　首都医科大学附属北京儿童医院
　　福建医科大学附属协和医院
　　南京医科大学第一附属医院　
　　华中科技大学附属同济医院

招收临床医学、生物信息学、生物统计学专业背景的学生。