简介
研究方向
发表论著
承担科研项目
项目组情况
招生信息

张维绮(ZHANG Weiqi)
博士生导师，研究员
E-Mail：zhangwq@big.ac.cn
研究领域：遗传学，基因组学、生物化学与分子生物学、生物信息学
导师简介：学习经历：
2001年9月-2005年6月，南昌大学，生物工程专业，理学学士学位
2005年9月-2011年6月，北京大学，细胞生物学专业，理学博士学位
工作经历：
2019年2月至今，中国科学院北京基因组所，研究员，博士生导师
2016年12月-2019年1月，中国科学院生物物理研究所，研究员
2015年10月-2016年12月，中国科学院生物物理研究所，副研究员
2011年10月-2015年10月，中国科学院生物物理研究所，助理研究员
学术兼职：
中国细胞生物学学会衰老细胞生物学分会委员
中国老年学会衰老与抗衰老科学委员会委员
获奖及荣誉：
2015年 中国科学院“青年创新促进会”
2015年 中国科协“青年人才托举工程”
2016年 首都十大疾病科技攻关创新型科技进展奖 （团体第三名）
2017年 北京市科学技术二等奖（团体第四名）
2018年 国家优秀青年基金


发育和衰老的表观遗传调控，基于干细胞的疾病模型和药物筛选

近期主要学术成果：
1. Shuai Ma#, Shuhui Sun#, Lingling Geng#, Moshi Song#, Wei Wang, Yanxia Ye, Qianzhao Ji, Zhiran Zou, Si Wang, Xiaojuan He, Wei Li, Concepcion Rodriguez Esteban, Xiao Long, Guoji Guo, Piu Chan, Qi Zhou, Juan Carlos Izpisua Belmonte*, Weiqi Zhang*, Jing Qu* and Guang-Hui Liu*. (2020). "Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging." Cell 180(5):984-1001.e22. (*Co-corresponding author)
2.Si Wang#, Yuxuan Zheng#, Jingyi Li#, Yang Yu#, Weiqi Zhang#, Moshi Song, Zunpeng Liu, Zheying Min, Huifang Hu, Ying Jing, Xiaojuan He, Liang Sun, Lifang Ma, Concepcion Rodriguez Esteban, Piu Chan, Jie Qiao, Qi Zhou, Juan Carlos Izpisua Belmonte*, Jing Qu*, Fuchou Tang* and Guang-Hui Liu*. (2020). "Single-Cell Transcriptomic Atlas of Primate Ovarian Aging." Cell 180(3): 585-600.e519. (#Co-first author)
3.Weiqi Zhang#, Haifeng Wan#, Guihai Feng#, Jing Qu#, Jiaqiang Wang, Yaobin Jing, Ruotong Ren, Zunpeng Liu, Linlin Zhang, Zhiguo Chen, Shuyan Wang, Yong Zhao, Zhaoxia Wang, Yun Yuan, Qi Zhou, Wei Li*, Guang-Hui Liu* and Baoyang Hu*. (2018). "Sirt6 Deficiency Results in Developmental Retardation in Cynomolgus Monkeys." Nature 560(7720): 661-665. (#Co-first author)
4.Weiqi Zhang#, Jingyi Li#, Keiichiro Suzuki#, Jing Qu#, Ping Wang, Junzhi Zhou, Xiaomeng Liu, Ruotong Ren, Xiuling Xu, Alejandro Ocampo, Tingting Yuan, Jiping Yang, Ying Li, Liang Shi, Dee Guan, Huize Pan, Shunlei Duan, Zhichao Ding, Mo Li, Fei Yi, Ruijun Bai, Yayu Wang, Chang Chen, Fuquan Yang, Xiaoyu Li, Zimei Wang, Emi Aizawa, April Goebl, Rupa Devi Soligalla, Pradeep Reddy, Concepcion Rodriguez Esteban, Fuchou Tang*, Guang-Hui Liu* and Juan Carlos Izpisua Belmonte*. (2015). "A Werner Syndrome Stem Cell Model Unveils Heterochromatin Alterations as a Driver of Human Aging." Science 348(6239): 1160-1163. (#Co-first author)
5.Nard Kubben, Weiqi Zhang#(Co-senior author), Lixia Wang, Ty C. Voss, Jiping Yang, Jing Qu#, Guang-Hui Liu* and Tom Misteli*. (2016). "Repression of the Antioxidant Nrf2 Pathway in Premature Aging." Cell 165(6): 1361-1374. (#Co-senior author)
6.Weiqi Zhang#, Jing Qu, Guang-Hui Liu* and Juan Carlos Izpisua Belmonte*. (2020). "The Ageing Epigenome and Its rejuvenation." Nature Reviews Molecular Cell Biology 21(3): 137-150. (#First author)
7.Lingling Geng#, Zunpeng Liu#, Weiqi Zhang#*, Wei Li, Zeming Wu, Wei Wang, Ruotong Ren, Yao Su, Peichang Wang, Liang Sun, Zhenyu Ju, Piu Chan, Moshi Song*, Jing Qu* and Guang-Hui Liu*. (2019). "Chemical Screen Identifies a Geroprotective Role of Quercetin in Premature Aging." Protein & Cell 10(6): 417-435. (#Co-first author) and (*Co-corresponding author)
2020
8.Si Wang#, Zheying Min#, Qianzhao Ji#, Lingling Geng, Yao Su, Zunpeng Liu, Huifang Hu, Lixia Wang, Weiqi Zhang, Keiichiro Suzuiki, Yu Huang, Puyao Zhang, Tie-Shan Tang, Jing Qu*, Yang Yu*, Guang-Hui Liu* and Jie Qiao*. (2020). "Rescue of Premature Aging Defects in Cockayne Syndrome Stem Cells by Crispr/Cas9-Mediated Gene Correction." Protein & Cell 11(1): 1-22.
9.Weiqi Zhang#,Shu Zhang#,Pengze Yan#,Jie Ren#,Moshi Song,Jingyi Li,Jinghui Lei,Huize Pan,Si Wang,Xibo Ma,Shuai Ma,Hongyu Li,Fei Sun,Haifeng Wan,Wei Li,Piu Chan,Qi Zhou,Guang-Hui Liu*,Fuchou Tang* & Jing Qu*. (2020)."A single-cell transcriptomic landscape of primate arterial aging." Nature Communications, 11（1）：2202. (#Co-first author)
10.Huifang Hu#, Qianzhao Ji#, Moshi Song#, Jie Ren, Zunpeng Liu, Zehua Wang, Xiaoqian Liu, Kaowen Yan, Jianli Hu, Yaobin Jing, Weiqi Zhang*, Guang-Hui Liu*, Jing Qu*. "ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin." Nucleic Acids Research, 2020. Accepted (*Co-corresponding author)
11.Shijia Bi#, Zunpeng Liu#, Zeming Wu, Zehua Wang, Xiaoqian Liu, Si Wang, Jie Ren, Yan Yao, Weiqi Zhang*, Moshi Song*, Guang-Hui Liu*, Jing Qu*. "SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer." Protein & Cell, 2020. Accepted (*Co-corresponding author)
2019
12.Lingling Geng#, Zunpeng Liu#, Si Wang#, Shuhui Sun#, Shuai Ma, Xiaoqian Liu, Piu Chan, Liang Sun, Moshi Song*, Weiqi Zhang*, Guang-Hui Liu* and Jing Qu*. (2019). "Low-Dose Quercetin Positively Regulates Mouse Healthspan." Protein & Cell 10(10): 770-775. (*Co-corresponding author)
13.Xing Zhang#, Zunpeng Liu#, Xiaoqian Liu#, Si Wang, Yiyuan Zhang, Xiaojuan He, Shuhui Sun, Shuai Ma, Ng Shyh-Chang, Feng Liu, Qiang Wang, Xiaoqun Wang, Lin Liu, Weiqi Zhang*, Moshi Song*, Guang-Hui Liu*, and Jing Qu*. (2019). "Telomere-Dependent and Telomere-Independent Roles of Rap1 in Regulating Human Stem Cell Homeostasis." Protein & Cell 10(9): 649-667. (*Co-corresponding author)
14.Fang Cheng#, Si Wang#, Moshi Song#, Zunpeng Liu#, Ping Liu#, Lei Wang#, Yanjiang Wang, Qian Zhao, Kaowen Yan, Piu Chan, Weiqi Zhang*, Jing Qu* and Guang-Hui Liu*. (2019). "Dj-1 Is Dispensable for Human Stem Cell Homeostasis." Protein & Cell 10(11): 846-853. (*Co-corresponding author)
15.Pengze Yan#, Qingqing Li#, Lixia Wang, Ping Lu, Keiichiro Suzuki, Zunpeng Liu, Jinghui Lei, Wei Li, Xiaojuan He, Si Wang, Jianjian Ding, Piu Chan, Weiqi Zhang (co-senior author), Moshi Song, Juan Carlos Izpisua Belmonte, Jing Qu*, Fuchou Tang*, and Guang-Hui Liu*. (2019). "Foxo3-Engineered Human Esc-Derived Vascular Cells Promote Vascular Protection and Regeneration." Cell Stem Cell 24(3): 447-461.e448. (Co-senior author)
16.Liping Deng#, Ruotong Ren#, Zunpeng Liu#, Moshi Song#, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillen, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu*, Guang-Hui Liu*. (2019). "Stabilizing Heterochromatin by Dgcr8 Alleviates Senescence and Osteoarthritis." Nature Communications 10(1): 3329.
17.Lina Fu#, Yuqiong Hu#, Moshi Song#, Zunpeng Liu, Weiqi Zhang, Fa-Xing Yu, Jun Wu, Si Wang, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu*, Fuchou Tang*, and Guang-Hui Liu*. (2019). "Up-Regulation of Foxd1 by Yap Alleviates Senescence and Osteoarthritis." PLOS Biology 17(4): e**.
18.Xiaoqing Ren#, Boqiang Hu#, Moshi Song, Zhichao Ding, Yujiao Dang, Zunpeng Liu, Weiqi Zhang, Qianzhao Ji, Ruotong Ren, Jianjian Ding, Piu Chan, Changtao Jiang, Keqiong Ye, Jing Qu*, Fuchou Tang*, and Guang-Hui Liu*. (2019). "Maintenance of Nucleolar Homeostasis by Cbx4 Alleviates Senescence and Osteoarthritis." Cell Reports 26(13): 3643-3656.e3647.
19.Chen Ling#, Zunpeng Liu#, Moshi Song#, Weiqi Zhang, Si Wang, Xiaoqian Liu, Shuai Ma, Shuhui Sun, Lina Fu, Qun Chu, Juan Carlos Izpisua Belmonte, Zhaoxia Wang*, Jing Qu*, Yun Yuan*, and Guang-Hui Liu*. (2019). "Modeling Cadasil Vascular Pathologies with Patient-Derived Induced Pluripotent Stem Cells." Protein & Cell 10(4): 249-271.
2018
20.Ping Wang#, Zunpeng Liu#, Xiaoqian Zhang#, Jingyi Li, Liang Sun, Zhenyu Ju, Jian Li, Piu Chan, Guang-Hui Liu*, Weiqi Zhang*, Moshi Song*, and Jing Qu*. (2018). "Crispr/Cas9-Mediated Gene Knockout Reveals a Guardian Role of Nf-Κb/Rela in Maintaining the Homeostasis of Human Vascular Cells." Protein & Cell 9(11): 945-965. (*Co-corresponding author)
21.Zeming Wu#, Weiqi Zhang#, Moshi Song#, Wei Wang, Gang Wei, Wei Li, Jinghui Lei, Yu Huang, Yanmei Sang, Piu Chan, Chang Chen, Jing Qu*, Keiichiro Suzuki*, Juan Carlos Izpisua Belmonte*, and Guang-Hui Liu*. (2018). "Differential Stem Cell Aging Kinetics in Hutchinson-Gilford Progeria Syndrome and Werner Syndrome." Protein & Cell 9(4): 333-350. (#Co-first author)
22.Weiqi Zhang#, Moshi Song#, Jing Qu*, and Guang-Hui Liu*. (2018). "Epigenetic Modifications in Cardiovascular Aging and Diseases." Circulation Research 123(7): 773-786. (#Co-first author)
23.Si Wang#, Boqiang Hu#, Zhichao Ding, Yujiao Dang, Jun Wu, Di Li, Xiaoling Liu, Bailong Xiao, Weiqi Zhang, Ruotong Ren, Jinghui Lei, Huifang Hu, Chang Chen, Piu Chan, Dong Li, Jing Qu*, Fuchou Tang*, and Guang-Hui Liu*. (2018). "Atf6 Safeguards Organelle Homeostasis and Cellular Aging in Human Mesenchymal Stem Cells." Cell Discovery 4(1): 2.
24.Shuyan Wang#, Zhongfeng Liu#, Yanxia Ye#, Bingnan Li, Tiantian Liu, Weiqi Zhang, Guang-Hui Liu, Y Alex Zhang, Jing Qu*, Dawei Xu*, and Zhiguo Chen*. (2018)."Ectopic Htert Expression Facilitates Reprograming of Fibroblasts Derived from Patients with Werner Syndrome as a Ws Cellular Model." Cell Death & Disease 9(9): 923.
2017
25.Jiping Yang#, Jingyi Li#, Keiichiro Suzuki#, Xiaomeng Liu, Jun Wu, Weiqi Zhang, Ruotong Ren, Weizhou Zhang, Piu Chan, Juan Carlos Izpisua Belmonte, Jing Qu*, Fuchou Tang*, and Guang-Hui Liu*. (2017). "Genetic Enhancement in Cultured Human Adult Stem Cells Conferred by a Single Nucleotide Recoding." Cell Research 27(9): 1178-1181.
26.Ruotong Ren#, Liping Deng#, Yanhong Xue#, Keiichiro Suzuki#, Weiqi Zhang, Yang Yu, Jun Wu, Liang Sun, Xiaojun Gong, Huiqin Luan, Fan Yang, Zhenyu Ju, Xiaoqing Ren, Si Wang, Hong Tang, Lingling Geng, Weizhou Zhang, Jian Li, Jie Qiao, Tao Xu*, Jing Qu*, and Guang-Hui Liu*. (2017) "Visualization of Aging-Associated Chromatin Alterations with an Engineered Tale System." Cell Research 27(4): 483-504.
2016
27.Ying Li#, Weizhou Zhang#, Liang Chang#, Yan Han, Liang Sun, Xiaojun Gong, Hong Tang, Zunpeng Liu, Huichao Deng, Yanxia Ye, Yu Wang, Jian Li, Jie Qiao, Jing Qu*, Weiqi Zhang*, and Guang-Hui Liu*. (2016). "Vitamin C Alleviates Aging Defects in a Stem Cell Model for Werner Syndrome." Protein & Cell 7(7): 478-488. (*Co-corresponding author)
28.Huize Pan#, Di Guan#, Xiaomeng Liu#, Jingyi Li, Lixia Wang, Jun Wu, Junzhi Zhou, Weizhou Zhang, Ruotong Ren, Weiqi Zhang, Ying Li, Jiping Yang, Ying Hao, Tingting Yuan, Guohong Yuan, Hu Wang, Zhenyu Ju, Zhiyong Mao, Jian Li, Jing Qu*, Fuchou Tang*, and Guang-Hui Liu*. (2016). "Sirt6 Safeguards Human Mesenchymal Stem Cells from Oxidative Stress by Coactivating Nrf2." Cell Research 26(2): 190-205.
29.Lina Fu#, Xiuling Xu#, Ruotong Ren#, Jun Wu, Weiqi Zhang, Jiping Yang, Xiaoqing Ren, Si Wang, Yang Zhao, Liang Sun, Yang Yu, Zhaoxia Wang, Ze Yang, Yun Yuan, Jie Qiao, Juan Carlos Izpisua Belmonte, Jing Qu*, and Guang-Hui Liu*. (2016). "Modeling Xeroderma Pigmentosum Associated Neurological Pathologies with Patients-Derived Ipscs." Protein & Cell 7(3): 210-221.
2015
30.Zhichao Ding#, Lina Sui#, Ruotong Ren#, Yanjun Liu, Xiuling Xu, Lina Fu, Ruijun Bai, Tingting Yuan, Ying Hao, Weiqi Zhang, Huize Pan, Wensu Liu, Han Yu, Concepcion Rodriguez Esteban, Xiaobing Yu, Ze Yang, Jian Li, Xiaomin Wang, Juan Carlos Izpisua Belmonte*, Guang-Hui Liu*, Fei Yi*, and Jing Qu*. (2015). "A Widely Adaptable Approach to Generate Integration-Free Ipscs from Non-Invasively Acquired Human Somatic Cells." Protein & Cell 6(5): 386-389.
31.Shunlei Duan#, Guohong Yuan#, Xiaomeng Liu#, Ruotong Ren, Jingyi Li, Weizhou Zhang, Jun Wu, Xiuling Xu, Lina Fu, Ying Li, Jiping Yang, Weiqi Zhang, Ruijun Bai, Fei Yi, Keiichiro Suzuki, Hua Gao, Concepcion Rodriguez Esteban, Chuanbao Zhang, Juan Carlos Izpisua Belmonte, Zhiguo Chen, Xiaomin Wang, Tao Jiang, Jing Qu*, Fuchou Tang*, and Guang-Hui Liu*. (2015). "Pten Deficiency Reprogrammes Human Neural Stem Cells Towards a Glioblastoma Stem Cell-Like Phenotype." Nature Communications 6(1): 10068.
2014
32.Guang-Hui Liu#, Keiichiro Suzuki#, Mo Li#, Jing Qu#, Nuria Montserrat, Carolina Tarantino, Ying Gu, Fei Yi, Xiuling Xu, Weiqi Zhang, Sergio Ruiz, Nongluk Plongthongkum, Kun Zhang, Shigeo Masuda, Emmanuel Nivet, Yuji Tsunekawa, Rupa Devi Soligalla, April Goebl, Emi Aizawa, Na Young Kim, Jessica Kim, Ilir Dubova, Ying Li, Ruotong Ren, Chris Benner, Antonio del Sol, Juan Bueren, Juan Pablo Trujillo, Jordi Surralles, Enrico Cappelli, Carlo Dufour, Concepcion Rodriguez Esteban, and Juan Carlos Izpisua Belmonte*. (2014). "Modelling Fanconi Anemia Pathogenesis and Therapeutics Using Integration-Free Patient-Derived Ipscs." Nature Communications 5(1): 4330.
33.Xiuling Xu#, Jiping Yang#, Lina Fu#, Ruotong Ren, Fei Yi, Keiichiro Suzuki, Kai Liu, Zhichao Ding, Jing Qu, Weiqi Zhang, Ying Li, Tingting Yuan, Guohong Yuan, Lina Sui, Di Guan, Shunlei Duan, Huize Pan, Ping Wang, Xiping Zhu, Nuria Montserrat, Ming Li, Ruijun Bai, Lin Liu, Juan Carlos Izpisua Belmonte*, and Guang-Hui Liu*. (2014). "Direct Reprogramming of Porcine Fibroblasts to Neural Progenitor Cells." Protein & Cell 5(1): 4-7.
2013
34.Weiqi Zhang#, Jing Qu, Keiichiro Suzuki, Guang-Hui Liu* and Juan Carlos Izpisua Belmonte*. (2013). "Concealing Cellular Defects in Pluripotent Stem Cells." Trends in Cell Biology 23(12): 587-592. (#First author)
35.Di Guan#, Weiqi Zhang#, Weizhou Zhang, Guang-Hui Liu*, and Juan Carlos Izpisua Belmonte*. (2013). "Switching Cell Fate, Ncrnas Coming to Play." Cell Death & Disease 4(1): e464-e464. (#Co-first author)
2012
36.Weiqi Zhang#, Shunlei Duan#, Ying Li, Xiuling Xu, Jing Qu*, Weizhou Zhang* and Guang-Hui Liu*. (2012). "Converted Neural Cells: Induced to a Cure?" Protein & Cell 3(2): 91-97. (#Co-first author)
37.Weiqi Zhang#, Zhichao Ding# and Guang-Hui Liu*. (2012). "Evolution of Ipsc Disease Models." Protein & Cell 3(1): 1-4. (#Co-first author)
38.Ping Wang#, Weiqi Zhang#, Jiping Yang, Jing Qu* and Guang-Hui Liu*. (2012). "Higher-Order Genomic Organization in Pluripotent Stem Cells." Protein & Cell 3(7): 483-486. (#Co-first author)
39.Weiqi Zhang#, Di Guan#, Jing Qu#, Weizhou Zhang* and Guang-Hui Liu*. (2012). "Non-Viral Ipscs: A Safe Way for Therapy?" Protein & Cell 3(4): 241-245. (#Co-first author)
2011
40.Huize Pan#, Weiqi Zhang#, Weizhou Zhang and Guang-Hui Liu*. (2011). "Find and Replace: Editing Human Genome in Pluripotent Stem Cells." Protein & Cell 2(12): 950-956. (#Co-first author)
41.Yanqin Li#, Qiang Zhang#, Xiaolei Yin#, Weifeng Yang, Yuanyuan Du, Pingping Hou, Jian Ge, Chun Liu, Weiqi Zhang, Xu Zhang, Yetao Wu, Honggang Li, Kang Liu, Chen Wu, Zhihua Song, Yang Zhao*, Yan Shi* and Hongkui Deng*. (2011). "Generation of Ipscs from Mouse Fibroblasts with a Single Gene, Oct4, and Small Molecules." Cell Research 21(1): 196-204.
42.Guang-Hui Liu#, Jing Qu#, Keiichiro Suzuki#, Emmanuel Nivet, Mo Li, Nuria Montserrat, Fei Yi, Xiuling Xu, Sergio Ruiz, Weiqi Zhang, Ulrich Wagner, Audrey Kim, Bing Ren, Ying Li, April Goebl, Jessica Kim, Rupa Devi Soligalla, Ilir Dubova, James Thompson, John Yates Iii, Concepcion Rodriguez Esteban, Ignacio Sancho-Martinez and Juan Carlos Izpisua Belmonte*. (2012). "Progressive Degeneration of Human Neural Stem Cells Caused by Pathogenic Lrrk2." Nature 491(7425): 603-607.





　　干细胞是机体组织器官再生的源泉，其自我更新与分化之间的动态平衡对于组织器官的生长发育和机能维持具有重要的作用。在人类的一生中，干细胞经历了蓬勃发育、维持和衰退的过程。这一过程受到严格的时空调控，而干细胞命运调控机制的失衡与人类疾病的发生息息相关。在衰老过程中，干细胞逐渐耗竭，是导致衰老和衰老相关疾病的发生的重要原因。
　　课题组主要围绕干细胞的命运决定和稳态维持，通过结合基因编辑技术、多谱系的干细胞分化技术、多层次组学手段、新型的动物模型等，系统研究再生与衰老的分子机制，特别是表观遗传因素在机体退化和病变中发生的作用。 取得的主要研究成果包括：（1）在衰老的遗传和表观遗传学基础方面，结合基因编辑、重编程和多能干细胞定向分化技术，建立儿童早衰症和成年早衰症等人类干细胞疾病模型，揭示了细胞核结构和表观遗传改变是人类早衰症和生理性衰老共同的驱动力(Science, 2015; Cell, 2016; Protein and Cell, 2018)；（2）建立了简便可扩大的人类干细胞平台，用于延缓衰老化合物的筛选评估和全基因组范围内关键的衰老调控基因的筛查。基于这一体系，目前已经发现如奥替普拉等小分子可以有效的延缓早衰和野生型人类干细胞衰老，为治疗早衰症和延缓自然衰老提供了思路和依据 (Cell, 2016; Protein and Cell, 2016)。3）利用长寿基因SIRT6敲除的基因工程猴，研究灵长类动物不同类型器官、组织、细胞中受SIRT6调节的分子信号网络 (Nature, 2018)。

生化、分子、细胞、基因组学与生物信息学及理科类