熊伟
单位：生命科学学院
地址：安徽合肥市黄山路中国科技大学西区新科技楼914房间
邮编：230026
电话：
个人主页： https://biox.ustc.edu.cn/2014/0224/c692a340190/page.htm
实验室介绍： http://x-lab.ustc.edu.cn/


个人简历 Personal resume


教授，博士生导师。中科院脑科学与智能技术卓越创新中心成员。北京大学学士及博士学位。科技部“中青年科技创新领军人才”、“****”科技创新领军人才。从事神经化学领域的相关科学研究，包括：脑衰老与神经退行性疾病、新型质谱技术研发、神经环路调控等。在Cell、Nature Neuroscience、Nature Chemical Biology、PNAS等国际期刊发表多篇第一及通讯作者论文。工作入选2018年度“中国生命科学十大进展”。主持过多项国家级科研项目，包括：基金委重点项目、863青年科学家、科技部“十三五”重点研发计划（课题组长）、中科院B类先导科技专项（课题组长）等。曾获中科院优秀导师、中科大杰出研究校长奖、唐立新优秀****奖等。


研究方向 Research direction


1、脑衰老与神经退行性疾病的发生发展机制
2、新型质谱技术研发及其在神经科学中的应用
3、感知觉的中枢神经环路和调控机制



招生信息 Enrollment information


招生招聘：实验室招聘分析化学、分子生物学、生物信息学等相关背景的co-PI、博士后和实验员，待遇从优。同时欢迎本科实习生和报考研究生。 联系方式：wxiong@ustc.edu.cn联系电话：


论文专著 The monograph


1)Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain - CELL - - 0092-8674
2)Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry - PNAS - 2017 - 114: 2586-2591
3)Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization - Analytical Chemistry - 2019 - 91(4): 2719-2726
4) Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry - Analytical Chemistry - 2019 - 91(10): 6616-6623
5)Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors - iScience - 2019 - 19: 634-646
6)The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. - The Journal of Biological Chemistry - 2020 - 295: 138-145
7)Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. - Neuropharmacology - 2018 - 133: 224-232
8)Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease - Nature Neuroscience - 2014 - 17: 232-239
9)Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. - Nature Chemical Biology - 2011 -
10)Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors - Journal of Experimental Medicine - 2012 -
11)A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. - Journal of Neuroscience - 2012 -
12)Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization. - Molecular Pharmacology - 2008 -
13)Loss of metabotropic glutamate receptor 2 escalates alcohol consumption - PNAS - 2013 -
14)Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. - Neuroscience - 2011 -
15)Receptor trafficking induced by μ-opioid-receptor phosphorylation. - Neuroscience & Biobehavioral Review - 2009 -
16)Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice. - Anesthesiology - 2012 -
17)Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols. - Journal of Pharmacology and Experimental Therapeutics - 2012 -
18)Involvement of endogenous cholecystokinin in morphine tolerance in the nucleus accumbens of rats. - Behavioural Brain Research - 2006 -
19)Involvements of mu- and kappa- opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats. - Neuroscience Letters - 2006 -