鲍坚强
单位：附属第一医院
地址：科大中区医学楼407
邮编：230027
电话：
个人主页：
实验室介绍： BaoLab.weebly.com


个人简历 Personal resume


鲍坚强，中国科大与附一院双聘研究员，博士生导师。长期专注于哺乳动物生殖生物学研究，建立优化了一套以胚胎干细胞(ES)同源重组技术为基础的高效制作遗传修饰小鼠动物模型(Genetically Engineered Mouse Model,GEMM)的方法，并结合体外细胞、分子生物学手段，发现了9个与哺乳动物雄性不育密切相关的遗传/表观遗传蛋白质编码基因和5个非编码微小RNA分子（miRNA），并阐明了6条与生殖细胞发育缺陷相关重要信号通路。在生殖发育生物学领域相关主流SCI期刊如PLoS Genetics, Development, Nucleic Acids Research, Cell Death & Differentiation, Cancer Research, JCI insight等共发表SCI论文26篇(第一作者/通讯作者14篇)，被引用900余次，获得美国德州表观****奖(Epigenetic Scholar)。


研究方向 Research direction


1、生殖生物学
2、细胞生物学
3、分子生物学



招生信息 Enrollment information


实验室招聘副研究员、助理研究员，常年招收博士后和研究生，享受中国科学技术大学及附一院相关福利待遇。欢迎有志于从事生殖发育生物学，或有丰富分子生物学，细胞生物学，生物信息学技术的优秀同仁加入，同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读博士学位。


论文专著 The monograph


1)Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases - Cancer Research - 2018 -
2)Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice - JCI insight - 2018 -
3)The arginine methyltransferase CARM1 represses p300•ACT•CREM - Nucleic Acids Research - 2018 -
4)UPF2-DependentNonsense-MediatedmRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTRTranscripts - PLoS Genetics - 2016 -
5)UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility byensuring fidelity of the transcriptome - Development - 2015 -
6)Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis - Proceedings of the National Academy of Sciences of the United States of America - 2014 -
7)RAN-Binding Protein 9 is Involved in Alternative Splicing and is Critical for Male Germ Cell Development and Male Fertility - PLoS Genetics - 2014 -
8)Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice - Cell death and differentiation - 2014 -
9)Male Germline Control of Transposable Elements1 - Biology of Reproduction - 2012 -
10)MicroRNA-449andMicroRNA-34b/cFunctionRedundantlyin MurineTestesbyTargetingE2FTranscription Factor-RetinoblastomaProtein(E2F-pRb)Pathway - Journal of Biological Chemistry - 2012 -