史庆华
单位：生命科学学院
地址：安徽省合肥市黄山路，中国科学技术大学生物楼648-649
邮编：230027
电话：+86-
个人主页： http://mcg.ustc.edu.cn
实验室介绍：


个人简历 Personal resume


史庆华，教授，博士生导师。国家****基金获得者。64年出生于江苏徐州。98年毕业于南京师范大学，获博士学位。92年10月-93年11月德国国立环境与健康研究中心(GSF-National Research Center for Environment and Health, Germany)访问****，96年10月-97年12月作为联合培养博士生在德国国立环境与健康研究中心学习。98年11月－01年12月加拿大卡加里大学(University of Calgary, Canada)博士后；02年1月－04年12月哈佛大学医学院(Harvard Medical School, USA)Research Fellow。06年主持中科院知识创新工程重要方向性项目；07年获得国家****科学基金、担任国家重大科学研究计划项目“卵泡发育的分子调控”首席科学家；2011年受聘为科技部国家重大科学研究计划专家组专家;现主持国家重点研发计划项目（2016-2020）、国家基金委重点项目（2017-2021）和中科院先导项目子课题（2017-2021）。现为中国科技大学合肥微尺度物质科学国家实验室PI(Principal Investigator)和生命科学学院教授、博士生导师。近10年来，作为第一或通信作者在《Nature》、《American Journal of Human Genetics》、《Current Biology》、《Nucleic Acids Research》和《Cell Research》等SCI杂志上发表系列研究论文60余篇,被他人引用2000余次。


研究方向 Research direction


1、分子细胞遗传学/肿瘤染色体异常的发生途径
2、生殖生物学/配子发生的遗传调控



招生信息 Enrollment information


仅招收硕博连读生考试科目：生化与分子生物学，细胞生物学联系方式：电话，email: qshi@ustc.edu.cn科研条件：本实验室有多种先进的仪器设备如SIM超高分辨显微镜、激光共聚焦、可进行长时间活细胞实时摄影的活细胞工作站、可进行单精子胞内注射的eppendorf显微操作系统等；有200平米的实验室1间、生物信息学实验室、人类生殖疾病资源库、高洁净细胞培养间2间和动物房3间；实验室科研项目较多、经费充足、研究生待遇好。


论文专著 The monograph


1)Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. - NATURE - 200510 - 437:1038－1042
2)Absence of age effect on meiotic recombination between human X and Y chromosomes - AMERICAN JOURNAL OF HUMAN GENETICS - 2002 - 71(2):254-261
3)Lagging chromosomes entrapped in micronuclei are not‘lost’by cells - Cell Research - 201202 - 2012
4)Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines - Chromosome Research - 201110 - 19(7):857-68
5)Complex relationship between meiotic recombination frequency and autosomal synaptonemal complex length per cell in normal human males - American Journal of Medical Genetics - 201202 - Epub ahead of print
6)Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries - PLoS One - 201101 - 6(1):e16046
7)Prediction of novel pre-microRNAs with high accuracy through boosting and SVM - Bioinformatics - 201103 - 27(10):1436-1437
8)The fate of micronucleated cells post X-irradiation detected by live cell imaging - DNA Repair (Amst) - 201103 - 10:629-638
9)Multiple origins of spontaneously arising micronuclei in HeLa cells: Direct evidence from long-term live cell imaging - MUTATION RESEARCH - 200811 - 646(1-2):41-49
10)Abnormal synapsis and recombination in an azoospermic male carrier of a reciprocal translocation t(1;21). - FERTILITY AND STERILITY - 200902 - 91(4):1293 e17-22
11)Cryopreservation has no effect on meiotic recombination and synapsis in testicular tissues - FERTILITY AND STERILITY - 200808 - 91(4):1404-7
12)Cigarette smoking and aneuploidy in human sperm - MOLECULAR REPRODUCTION AND DEVELOPMENT - 200108 - 59(4):417-421
13)Recombination in the pseudoautosomal region in a 47, XYY male - HUMAN GENETICS - 200108 - 109(2):143-145
14)Increased nondisjunction of chromosome 21 with age in human peripheral lymphocytes - MUTATION RESEARCH - 200007 - 452(1):27-36
15)Incidence of mosaic cell lines in vivo and malsegregation of chromosome 21 in lymphocytes in vitro of trisomy 21 patients: detection by fluorescence in situ hybridization on binucleated lymphocytes - HUMAN GENETICS - 200001 - 106(1):29-35
16)Aneuploidy in human spermatozoa: FISH analysis in men with constitutional chromosomal abnormalities, and in infertile men - REPRODUCTION - 200105 - 121(5):655-666
17)Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm - AMERICAN JOURNAL OF MEDICAL GENETICS - 200102 - 99(1):34-38
18)Multicolor fluorescence in situ hybridization analysis of meiotic chromosome segregation in a 47,XYY male and a review of the literature - AMERICAN JOURNAL OF MEDICAL GENETICS - 200007 - 936(1):40-46
19)Spontaneous frequencies of aneuploid and diploid sperm in 10 normal Chinese men: assessed by multicolor fluorescence in situ hybridization - CYTOGENETICS AND CELL GENETICS - 2000 - 90(1-2):79-83
20)Aneuploidy in human sperm: a review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factors - CYTOGENETICS AND CELL GENETICS - 2000 - 90(3-4):219-226
21)The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells - J Clin Invest - 200912 - 119(12):3626-36
22)Comparative proteome profile of immature rat ovary during primordial follicle assembly and development - Proteomics - 200907 - 9(13):3425-34
23)Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity - J Biol Chem - 201006 - 285(25):19060-7