张智
单位：生命科学学院
地址：合肥市黄山路443号生命科学学院
邮编：230026
电话：**
个人主页： https://biox.ustc.edu.cn/2012/1105/c692a340192/page.htm
实验室介绍：


个人简历 Personal resume


中国科学技术大学生命科学学院教授、博士生导师，科技部青年973首席科学家。2001年毕业于安徽大学并获生物化学学士学位，2008年获中国科学技术大学神经生物学博士学位，2008-2012年在美国德克萨斯大学MD Anderson cancer center从事博士后工作，主要研究阿片类药物的镇痛和疼痛产生的表观遗传学机制，相关研究成果发表在Nature Medicine, Journal of Neuroscience, Cerebral Cortex和FASEB J等学术期刊上，其中两篇论文分别被Nature Reviews Neuroscience和Nature Reviews Drug Discovery杂志Highlight。2012年10月起任中国科学技术大学生命科学学院教授。


研究方向 Research direction


1、慢性疼痛
2、抑郁症



招生信息 Enrollment information





论文专著 The monograph


1)A neural circuit for comorbid depressive symptoms in chronic pain - NATURE NEUROSCIENCE - - 1097-6256
2)A basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior - PNAS - 2019 -
3)A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain - PAIN - - 0304-3959
4)Persistent inflammation-induced upregulation of BDNF promotes synaptic delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor GluA1 subunits in descending pain modulatory circuits - J. Biol. Chem. - 2014 -
5)MeCP2 repression of G9a in regulation of pain and morphine reward - The Journal of Neuroscience - 2014 -
6)Epigenetic suppression of GAD65 expression mediates persistent pain - Nature Medicine - 2011 -
7)Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation - Molecular Pharmacology - 2013 -
8)Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception - Molecular Pharmacology - 2012 -
9)Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval - Cerebral Cortex - 2008 -
10)Synaptic mechanism for functional synergism between delta- and mu-opioid receptors - Journal of Neuroscience - 2010 -
11)Nerve growth factor-regulated emergence of functional delta-opioid receptors - Journal of Neuroscience - 2010 -
12)Persistent Pain Facilitates Response to Morphine Reward by Downregulation of Central Amygdala GABAergic Function - Neuropsychopharmacology - 2014 -
13)Central Amygdala GluA1 Facilitates Associative Learning of Opioid Reward - Journal of Neuroscience - 2013 -