魏海明
单位：生命科学与医学部
地址：黄山路443号中国科学技术大学生命科学学院
邮编：230027
电话：+86-
个人主页： http://ioi.ustc.edu.cn/whm_lab
实验室介绍：


个人简历 Personal resume


1996.7－2000.10山东省医学科学院基础医学研究所助理研究员；2000.11－2001.8山东省医学科学院基础医学研究所副研究员；2001.9－2005.12中国科学技术大学生命学院副教授；2005.12－至今中国科学技术大学生命学院教授;1993.8-1996.7山东省医学科学院硕士研究生；2000.8-2003.7山东大学博士研究生


研究方向 Research direction


1、天然免疫识别及其分子机制
2、肿瘤免疫学与肿瘤生物治疗
3、天然免疫系统与重大疾病



招生信息 Enrollment information


仅招收硕博连读生执行中科大博士生录取标准，不附加其他条件。


论文专著 The monograph


1)Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors. - Cancer Sci. - 200903 - 2009 Mar;100(3):529-36.
2)Diagnostic utility of LunX mRNA in peripheral blood and pleural fluid in patients with primary non-small cell lung cancer. - BMC Cancer - 200805 - 2008 May 31;8:156.
3)Involvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus - Journal of Immunology - 2011 - 186(6):3421-3431
4)IFN-r induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice - Journal of Autoimmunity - 2012 - 38(1):20-28
5)CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells - Immunology - 2011 - 133(3):350-359
6)IGF-1 promotes the development and cytotoxic activity of human NK cells. - Nat Commun. - 2013 - 4:1479
7)Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. - Proc Natl Acad Sci U S A. - 2013 - 2013 Jan 15;110(3):E231-40
8)TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. - PLoS Pathog. - 2012 - 2012;8(3):e**
9)Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice - BBRC - 2007 - 2007 Dec;28;364(4):978-84
10)Toll-like receptor 3 agonist induces impairment of uterine vascular remodeling and fetal losses in CBAxDBA/2 mice - J Reprod Immunol. - 200706 - 2007;74(1-2):61-7
11)Involvement of Human natural killer (NK) cells in asthma pathogenesis: NK2 cells in type-two cytokine predominance. - J Allergy Clin Immunol. - 200504 - 2005;115(4): 841-7
12)Tumor-induced suppression of interferon production and enhancement　of interleukin-10 production by natural killer (NK) cells: paralleled to CD4+ T cells. - Molecular Immunology - 200505 - 2005;42(9):1023-31
13)NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice - PNAS - 200705 - 2007;104(18):7512-5
14)Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. - Hepatology. - 200802 - 2008;47(2):648-58.
15)IFN-producing Killer Dendritic Cells Contribute to the Inhibitory Effect of Poly I:C on the Progression of Murine Melanoma. - J Immunother. - 200807 - 2008;31(6):555-62.
16)Hepatocytes proteomic alteration and seroproteome analysis of HBV-transgenic mice. - Proteomics. - 200901 - 2009;9(1):87-105
17)Toll-like receptor 3 agonist enhances IFN-rand TNF-a production by murine uNK cells - Int Immunopharmacol - 200705 - 2007 May;7(5):588-96
18)Synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, inhibit the function of human NK cells: implication in therapy of autoimmune liver injury. - Peptides - 200503 - 2005; 26(3): 405-12.
19)Recognition of Double-Stranded RNA by TLR3 induces Severe Small Intestinal Injury in Mice. - J Immunol. - 200704 - 2007;178(7):4548-56
20)Application of optical tweezers in the research of molecular interaction between lymphocyte function associated antigen-1 and its monoclonal antibody. - Cell Mol Immunol. - 200706 - 2007;4(3):221-5.