肖卫华
单位：生命科学学院
地址：合肥市黄山路443号
邮编：230027
电话：+86-
个人主页： http://lstt.ustc.edu.cn/a/gb2312/chengyuanjieshao/2011/0612/1.html
实验室介绍： http://lstt.ustc.edu.cn


个人简历 Personal resume


肖卫华，教授，博士导师。1962年出生于吉林长春。1985年毕业于白求恩医科大学，2002年美国约翰·霍普金斯大学硕士。2008年吉林大学医学博士。1985-1995年长春生物制品研究所应用分子生物助理研究员，1995年-1998年美国马里兰大学肿瘤研究中心博士后，1998-2004年美国国立肿瘤研究院研究员，2004年10月-现在中国科学技术大学生命科学学院教授。


研究方向 Research direction


1、肿瘤免疫
2、生物药物



招生信息 Enrollment information


仅招收硕博连读生, 招收对肿瘤和免疫细胞中信号传导通路研究感兴趣且具有较扎实理论基础和分子生物学实验操作能力的考生;招收对生物医药研制和开发有兴趣的考生。特别要求个性开朗、乐观、热爱生活、勇于挑战、有责任心，对工作认真负责、有耐心和对科研有激情的考生。


论文专著 The monograph


1)Reduced expression of ΔΝp63α in cervical squamous cell carcinoma. - Clin Invest Med. - 2011 - 34(3):E184.
2)In vivo activity of novel anti-ErbB2 antibody chA21 alone and with Paclitaxel or Trastuzumab in breast and ovarian cancer xenograft models - Cancer Immunol Immunother. - 2011 - 60(3):339-48.
3)Gene associated with retinoid-interferon-induced mortality-19 suppresses growth of lung adenocarcinoma tumor in vitro and in vivo. - Lung Cancer. - 2011 - 72(3):287-93
4)Identification and characterization of GRIM-1, a cell-death-associated gene product. - J Cell Sci. - 2010 - 123(Pt 16):2781-91
5)Transcription factor E2F1 suppresses dendritic cell maturation. - J Immunol. - 2010 - 184(11):6084-91
6)Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. - J Biol Chem. - 2009 - 284(50):34600-6.
7)Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers. - J Interferon Cytokine Res. - 2009 - 29(10):695-703
8)Expression and clinical significance of GRIM-19 in non-small cell lung cancer - Ai Zheng. - 2009 - 28(4):431-5
9)E2F1 induces tumor cell survival via NF-κB-dependent induction of EGR1 transcription in prostate cancer - Cancer Research - 2009 - 2009.69（6）;2324-2331
10)外周血单核细胞来源的树突状细胞成熟过程中Toll样受体的既时表达变化 - 《中华微生物和免疫学杂志》 - 2008 - 2008（7）
11)转录因子PAX5对多发性骨髓瘤细胞IM9的抗凋亡及促增生作用 - 中国免疫学杂志 - 2008 - 2008（24）
12)人干扰素α2b和IgG Fc片段融合蛋白显著延长体内半衰期 - 生物工程学报 - 2008 - 2008年第一期
13)The interferon signaling network and transcription factor C/EBP-beta. - Cell Mol Immunol. - 2007 - 4(6):407-18
14)mRNA secondary structure at start AUG codon is a key limiting factor for human protein expression in Escherichia coli. - Biochem Biophys Res Commun. - 2006 - 349(1):69-78
15)Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis. - Cancer Res. - 2005 - 65(14):6255-63
16)Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. - J Biol Chem. - 2005 - 280(6):4182-7
17)Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. - Immunity. - 2004 - 20(2):205-18
18)Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. - Nat Med. - 2004 - 10(1):40-7
19)Advances in NF-kappaB signaling transduction and transcription. - Cell Mol Immunol. - 2004 - 1(6):425-35
20)NF-B Activates IL-6 Expression through cooperation with c-Jun and IL6-AP1 site,But Is Independent of Its IL6- NF B Regulatory site in Autocrine Human Multiple Myeloma Cells. - Cancer Biology and Therapy - 2004 - 3:108-113
21)Co-operative Functions between nuclear factors NF-B and CCAT/enhancer-binding protein-beta(C/EBP)REGULATE THE il-6 Promoter in autocrine human prostate cancer cells. - Prostate - 2004 - 61:354-370
22)The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity. - Cancer Res. - 2003 - 63(9):2046-51
23)Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands. - J Biol Chem. - 2002 - 277(6):3973-8
24)CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma)gene transcription in human monocytic cells. - J.Biol.Chem. - 2001 - 276-23275-23281
25)Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta) - Biochim.Biophys.Acta - 2000 - 1492-163-171
26)Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta). - Biochim Biophys Acta. - 2000 - 1492(1):163-71
27)CCAAT/enhancer-binding protein-beta regulates interferon-induced transcription through a novel element. - J Biol Chem. - 2000 - 275(17):12626-32
28)Regulation of interferon-alpha/beta-stimulated gene expression through the gamma-activated transcriptional element. - Antiviral Res. - 1999 - 40(3):145-53
29)Gamma interferon augments macrophage activation by lipopolysaccharide by two distinct mechanisms, at the signal transduction level and via an autocrine mechanism involving tumor necrosis factor alpha and interleukin-1. - Infect Immun. - 1999 - 67(1):206-12
30)Induction of interferon synthesis and activation of interferon-stimulated genes by liposomal transfection reagents. - J Interferon Cytokine Res. - 1998 - 18(11):947-52
31)Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid. - Mol Cell Biol. - 1998 - 18(11):6493-504
32)The polyoma virus T antigen interferes with interferon-inducible gene expression. - Proc Natl Acad Sci U S A. - 1998 - 95(3):1085-90
33)The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc. - Proc Natl Acad Sci U S A. - 1997 - 94(14):7227-3
34)Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid. - J Biol Chem. - 1997 - 272(15):9742-8
35)Interferon gamma-induced transcription of the murine ISGF3gamma (p48) gene is mediated by novel factors. - Proc Natl Acad Sci U S A. - 1997 - 94(1):103-8