姚雪彪
单位：生命科学学院
地址：皖合肥中国科学技术大学生命科学学院
邮编：230027
电话：
个人主页： http://biox.ustc.edu.cn/szdw/szcjxz/201112/t**_125727.html
实验室介绍： http://lcd.ustc.edu.cn


个人简历 Personal resume


姚雪彪，博士，教育部“长江计划”****，国家自然科学基金委“****基金”获得者，国家自然科学基金委“着丝粒动态组装与调控”创新群体负责人(2017-2022)。1995年美国加州大学伯克利分校获细胞分子生物学博士学位, 1997年受聘为美国威斯康星州医学院生理系助理教授, 1998年入选首批教育部“长江计划”****计划。1999年入选“国家自然科学****基金”。现任中国科学技术大学教授、安徽省细胞动力学与化学生物学重点实验室主任。作为项目首席科学家主持了973 项目“调控细胞增殖重要蛋白质作用网络的研究”（2002-2008）。担任国际期刊《J. Biol. Chem.》、《Cell Discovery》、《Cell Research》编委，《J. Mol. Cell Biol.》、《BMC Cell Biology》副主编。美国Keystone Symposium SAB member。主要从事细胞动力学分子调控网络机制及细胞命运可塑性调控分子机制方面的研究，回国后，作为通讯作者在《Cancer Cell》、《Nat. Rev. Mol. Cell Biol.》、《Nat. Chem. Biol》、《Nat. Communs.》、《PNAS》、《Cell Research》和《Cancer Research》等国际学术期刊发表通讯作者学术论文100 余篇。 培养博士毕业生61名，其中包括“中科院优秀博士论文”、教育部“百篇优秀博士论文”提名奖、吴瑞奖、教育部“新世纪优秀人才”、中组部"****"计划获得者多名。


研究方向 Research direction


1、着丝粒组装动力学与干细胞
2、肿瘤细胞动力学与化学生物学干预
3、超高分辨率显微镜与分子生物物理学



招生信息 Enrollment information


仅招收硕博连读生，生物化学、细胞生物学、分子生物学


论文专著 The monograph Researcher ID


1)CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3 - cancer cell - 120412 - 19(4): 541-555
2)Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking - Mol Biol. Cell - 2014 - 25,4166-74.
3)Spatial control of proton pump H,K-ATPase docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 interaction - J Biol. Chem - 2014 - 289, 33333-42
4)Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. - Cancer Res. - 110301 - 71:1721-1729
5)Aurora b kinase activation requires survivin priming phosphorylation by plk1. - J Mol Cell Biol. - 101215 - 3:260-267
6)Mitotic regulator Mis18β interacts with and specifies the centromeric assembly of molecular chaperone HJURP - J Biol. Chem - 2014 - 289, 8326-8336
7)HP1α interacts with borealin and specifies the centromere localization of chromosomal passenger complex - J Biol Chem. - 2014 - 289, 20638-20649.
8)A general user interface for prediction servers of proteins' post-translational modifi cation sites - Nature Protocol - 2006 - 1, 1318-1321.
9)Spatiotemporal dynamics of chromatin protein HP1α is essential for accurate chromosome segregation during cell division. - J Biol Chem - 2014 - 289, 26249-62.
10)Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. - Oncogene - 2008 - 27: 931-941.
11)Phosphorylation of BAR domain of ACAP4 regulates membrane tubulation. - Proc Natl Acad Sci U S A - 2013 - 110, 11023-8.
12)Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression - J Biol Chem - 200709 - 282(37):27414-23
13)Acetylation-dependent regulation of kinetochore microtubule signaling by PCAF acetyltransferase - Proc Natl Acad Sci U S A - 2012 - 109, 16564-9.
14)The structure of structure of the FANCM-MHF complex reveals physical features for functional assembly. - Nature Commun - 2012 - 3, 782-791.
15)SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis. - J Mol Cell Biol. - 2012 - 4, 331-340.
16)CCL18 from tumor associated macrophages promotes breast cancer metastasis via CCR18. - Cancer Cell. - 2011 - 19, 541-55
17)PhosSNP for systematic analysis of genetic polymorphisms that influence protein phosphorylation - Mol Cell Proteomics. - 2010 - 9, 623-634.
18)Probing cenp-e function in chromosome dynamics using small molecule inhibitor syntelin. - Cell Res. - 101202 - 20:1386-1389
19)TIP150 interacts with and targets MCAK to the plus-end of microtubules - EMBO Rep - 2009 - 10, 857-65.
20)Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death - Cell Res. - 2009 - 19, 1350-1362.
21)Phosphorylation of Sgo1 by NEK2A is essential for chromosome segregation. - Cell Res. - 2007 - 17
22)Proteomic identification and functional characterization of a novel ARF6 GTPa se-activating protein ACAP4 - Mol.& Cell Proteomics - 2006 - 5, 1437-1449
23)Cell biology of acid secretion by parietal cells. - Ann.Rev.Physiol - 2003 - 2003 65:103-31
24)CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic check - Nature Cell Biology . - 200008 - 2:484-491,August 2000