梁丹 职称：教授
学历：博士
邮箱：ahmuxl@sina.com
地址：安徽省合肥市蜀山区梅山路安徽医科大学第一附属医院科教大楼8楼,230032

个人简介
科研领域
代表性论文
研究课题

2020.09-至今 安徽医科大学国家卫生健康委配子及生殖道异常研究重点实验室，教授
2017.02-2020.08 美国俄勒冈健康与科技大学胚胎干细胞与基因治疗中心，博士后
2010.09-2016.07 中国科学院上海生物化学与细胞生物所，博士
2006.09-2010.07 安徽大学生命科学学院生物技术专业，学士





早期胚胎发育与生殖健康至关重要，本课题组基于基因编辑，胚胎显微操作技术以及体细胞重编程技术，长期致力小鼠与人的早期胚胎发育、体细胞重编程与生殖医学领域相关研究，曾在Cell Stem Cell ，Cell以及 Nature等国际重要期刊上发表多篇学术论文。目前的研究工作集中在：
一、卵胞质中母源因子对早期胚胎发育以及体细胞重编程的作用以及机制研究；
二、人以及鼠受精卵中CRISPR/Cas9介导的DNA双链断裂修复机制以及安全性研究。



1. Wu, Y*,Liang, D.*, Wang, Y., Bai, M., Tang, W., Bao, S., Yan, Z., Li, D., and Li, J. (2013). Correction of a genetic disease in mouse via use of CRISPR-Cas9.Cell Stem Cell13, 659-662.（* 共同一作）(影响因子IF=25.3)


2. Guo, F. *, Li, X. *,Liang, D. *, Li, T. *, Zhu, P., Guo, H., Wu, X., Wen, L., Gu, T.P., Hu, B., et al. (2014). Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote.Cell stem cell15, 447-458. （* 共同一作）(影响因子IF=25.3)


3. Bai, M.*,Liang, D.*, Wang, Y., Li, Q., Wu, Y., and Li, J. (2016). Spermatogenic Cell-Specific Gene Mutation in Mice via CRISPR-Cas9.J Genet Genomics43, 289-296. （* 共同一作）(IF=4.1)


4.Liang, D., Wu, Y. and Li, J. (2015). Progress of CRISPR-Cas9 in stem cell research.Chinese Bulletin of Life Science1, 27


5. Yang, H., Shi, L., Wang, B.A.,Liang, D., Zhong, C., Liu, W., Nie, Y., Liu, J., Zhao, J., Gao, X., et al. (2012). Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells.Cell149, 605-617. (影响因子=32.4)


6. Yu, Y.,Liang, D., Tian, Q., Chen, X., Jiang, B., Chou, B.K., Hu, P., Cheng, L., Gao, P., Li, J., et al. (2013). Stimulation of Somatic Cell Reprogramming by Eras-Akt-Foxo1 Signaling Axis.Stem Cells32, 349-363. (影响因子=7.7)


7. Wu, Y., Zhou, H., Fan, X., Zhang, Y., Zhang, M., Wang, Y., Xie, Z., Bai, M., Yin, Q.,Liang, D., et al. (2014). Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells.Cell Res25, 67-69. (影响因子=12)


8. Zhu, W., Yao, X., Liang, Y.,Liang, D., Song, L., Jing, N., Li, J., and Wang, G. (2015). Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling.Development142, 465-476. (影响因子=6.1)


9. Zuo, E., Cai, Y.J., Li, K., Wei, Y., Wang, B.A., Sun, Y., Liu, Z., Liu, J., Hu, X., Wei, W.,Liang, D., et al. (2017). One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.Cell Res27, 933-945. (影响因子=14.7)


10. Ma, H., Marti-Gutierrez, N., Park, S.W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A.,Liang, D., et al. (2018). Ma et al. reply.Nature560, E10-E23. (影响因子=43.1)


11. Ma, H., Hayama, T., Van Dyken, C., Darby, H., Koski, A., Lee, Y., Gutierrez, N.M., Yamada, S., Li, Y., Andrews, M., Ahmed, R.,Liang, D., et al. (2019). Deleterious mtDNA Mutations are Common in Mature Oocytes.Biol Reprod102,607-619. (影响因子=3.0)


12. Ma, H., Van Dyken, C., Darby, H.,Mikhalchenko, A., Gutierrez, N.M., Koski, A.,Liang, D., Li, Y., et al. (2020). Germline transmission of donor, maternal and paternal mtDNA in primates.Human Reproduction00, 1-13. (影响因子=5.7)





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