徐马飞 职称：教授
学历：博士
邮箱：xumafei@ahmu.edu.cn
地址：合肥市梅山路81号，安徽医科大学，知行楼B座，230032





个人简介
科研领域
代表性论文
研究课题

2020.04-至今 安徽医科大学生命科学院，教授
2012.11-2019.12 美国贝勒医学院分子细胞系，博士后
2005.09-2012.07 中科院上海生命科学研究院，博士
1998.09-2002.07 浙江大学生物科学与技术系，学士





本实验室长期关注转录因子在肿瘤发生发展中的作用，致力于用动物模型，分子生物学，细胞生物学等手段，探索肿瘤发生的分子机制，寻找潜在的治疗靶点。目前的研究工作集中在两个方向：一是转录因子在前列腺癌内分泌治疗耐受中的作用；二是转录因子在端粒酶不依赖的ALT（Alternative Lengthening of Telomeres）肿瘤细胞中的作用，包括端粒的表观遗传调控，基因组稳定性等等。






1.Xu M, Qin J, Wang L, Lee H, Kao C, Liu D, Zhou S, Chen J, Tsai M, Tsai S. Nuclear receptors regulate alternative lengthening of telomeres through a novel non-canonical FANCD2 pathway.Sci. Adv.. 2019, 5(10): eaax6366.
2. Wang L,Xu M, Kao C, Tsai S, Tsai M. JQ1 promotes prostate cancer invasion through FOXA1 inactivation in a BET protein-independent pathway.J. Clin. Invest., 2020, 130(4): 1782-1792.
3.Wang L, Cheng C, Qin J,Xu M, Kao C, Shi J, You E, Gong W, Rosa L, Peter C, Louis S, Franck M, Timothy S, Peter H, H. Eric X, Tsai S, Tsai M. The use of small molecule inhibitors targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.Sci. Adv., 2020, 6(18): eaaz8031.
4. Lee H, Kao C, Lin S, Xu M, Xie X, Tsai M, Tsai M. Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.Sci. Rep.. 2017, 7(1): 3136.
5. Wang L,Xu M, Qin J, Lin S, Lee H, Tsai S, Tsai M. MPC1. A key gene in cancer metabo-lism, is regulated by COUPTFII in human prostate cancer.Oncotarget, 2016, 7(12): 14673-83.
6.Xu M, Qin J, Tsai S, Tsai M. The role of the orphan nuclear receptor COUP-TFII in tumor igenesis. Acta. Pharmacol. Sin., 2015, 36(1): 32-6.
7. Dani?lle G, F. Nienke B, Claudia G, Xu M, Joep de L, Shalini J, Wojciech W, Donna M. M, Helger G. Y, Rolph P, Lisenka E.L.M. V, Liesbeth S, Ellen A.W. Blokl Chun-An Chen, Baylor-Hopkins Center for Mendelian Genomics, Richard A. Lewis, Sophia Y. Tsai, Richard A. Gibbs, Ming-Jer Tsai, James R. Lupski, Huda Y. Zoghbi, Frans P.M. Cremers, Bert B.A. de Vries Christian P. Schaaf. NR2F1 mutations cause optic atrophy with intellectual disability.Am. J. Hum. Genet., 2014, 94(2): 303-9.
8.Xu M, Zhang F, Da L, Li T, Zhao M. Microspherule protein 2 associates with ASK1 acts as a negative regulator of stress-induced ASK1 activation.FEBS Lett., 2012, 586(12): 1678-86.
9. Chen G, Da L, Xu Y,Xu M, Song L, Li T, Zhao M. C-terminal amino acids 290-328 of LPTS/ PinX1 confer telomerase inhibition.Biochem. Biophys. Res. Commun., 2010, 398(4): 683-9.
10. Sun C,Xu M, Xing Z,Wu Z, Li Y, Li T, Zhao M. Expression function on embryonic development of lissencephaly-1 genes in zebrafish.Acta. Biochim. Biophys. Sin. (Shanghai), 2009 , 41(8): 677-88.





研究课题暂无