姓名：朱勍工作部门：生物与环境工程学院性别：男技术职称：教授最高学位：博士民族：汉籍贯：浙江义乌联系方式：18329193166Email:zhuq@zjut.edu.cn电话：0571-88320781主要研究方向：化学生物学、生物催化、药物合成简历：2005-今：浙江工业大学生物化工系2004-2005：化学生物博士后，哥伦比亚大学化学系2001-2004:化学生物ResearchFellow，化学系,新加坡国立大学1998-2001:有机化学博士，化学系,浙江大学研究（情况）项目：1.新型近红外水解酶FRET探针设计、制备及可视化研究，国家自然科学基金，80万，2013-20162.点击化学构建双活性位点单胺氧化酶抑制剂组合库及构效关系的研究，浙江省自然科学基金，8万，2012-20133.手性酸的化学-酶法耦联合成技术-高效生物催化剂的高通量筛选及分子定向进化,863计划子项目，80万，2011-20124.环氧化物水解酶在环氧化物手性拆分中的研究及应用，浙江省“钱江人才”计划项目，12万，2006-20095.高灵敏度钙/钙调素依赖性蛋白激酶（II）荧光探针的设计、合成及性能研究，浙江省自然科学基金，8万，2008-20106.高灵敏度、高通量筛选腈类化合物降解菌的研究，污染控制与资源化研究国家重点实验室项目，2万，2006-20087.教育部留学回国人员科研启动项目，教育部，1.5万，2007-20098.新型抗球虫药氢溴酸常山酮的开发研究，浙江省科技厅面上项目，10万，2010-2012发表的论文、专著、教材：1.LongSB,ChenL,XiangYM,SongMG,ZhengYG,ZhuQ(通讯作者),“Anactivity-basedfluorogenicprobeforsensitiveandselectivemonoamineoxidase-Bdetection”,Chem.Commun.,2012,48,7164–7166.2.WeiC,ChenYY,ShenHL,WangS,ChenL,ZhuQ(通讯作者),BiocatalyticresolutionofbenzylglycidyletheranditsderivatesbyTalaromycesflavus:effectofphenylringsubstituentsonenantioselectivity,Biotech.Lett.2012,34(8),1499-1503.3.ShenW,LongSB,YuSA,ChenWW,ZhuQ(通讯作者),“Design,synthesis,evaluationofanactivity-basedprobeforcellularimagingofmonoamineoxidases”,Med.Chem.Res.,2012,21,3858–3862.4.ShenW,FangY,TongAF,ZhuQ(通讯作者),“Synthesisandstructure–activityandrelationshipofacylthioureaderivativesasinhibitorsofmicrosomalepoxidehydrolase”,Med.Chem.Res.,2012,21,4214–4218.5.VendrellM,KrishnaGG,GhoshKK,ZhaiDT,LeeJK,ZhuQ,YauYH,ShochatSG,KimHR,ChungeJHandChangYT,“Solid-phasesynthesisofBODIPYdyesanddevelopmentofanimmunoglobulinfluorescentsensor”,Chem.Commun.,2011,47,8424–8426.6.ChaiSJ,LaiYF,XuJC,ZhengH,ZhuQ,ZhangPF,“One-PotSynthesisofSpirooxindoleDerivativesCatalyzedbyLipaseinthePresenceofWater”,Adv.Syn.Catal.,2011,353(2-3),371-375.7.ShengYM,WeiC,ZhangZF,WangS,ZhuQ(通讯作者),“EnantioselectiveHydrolysisofGlycidylMethylphenylEthersbyBotryosphaeriaDothideaZJUZQ007:EffectofSubstitutionPatternonEnantioselectivity”,ApplBiochemBiotechnol,2011,164,125-132.8.JiaZ,ZhuQ(通讯作者)“'Click'assemblyofselectiveinhibitorsforMAO-A”,Bioorg.Med.Chem.Lett.2010,20(21),6222-6225.9.ZhuQ,ZhanR.Y,LiuB,“HomogeneousDetectionofTrypsininProteinMixturesBasedonFluorescenceResonanceEnergyTransferbetweenAnionicConjugatedPolymerandFluorescentProbe”,Maromol.Rap.Commun.,2010,31(12),1060-1064.10.JiaZ,ShenW,ZhuQ(通讯作者),“MonoamineOxidaseInhibitors:Benzylidene-prop-2-ynyl-aminesAnalogues”Biol.Pharm.Bull.2010,33(4),725-728.11.ZhangZF,ShengYM,JiangKY,ZhuQ(通讯作者),“Bio-resolutionofglycidyl(o,m,p)-methylphenylethersbyBacillusmegaterium”Biotech.Lett.2010,32(4),513-516.12.ShenW,ZhangJM,MaoGJ,ZhuQ(通讯作者),“ALong-Wavelength,FluorogenicProbeforEpoxideHydrolase:7-(2-(Oxiran-2-yl)ethoxy)Resorufin”Biol.Pharm.Bull.2009,32(9),1496-1499.13.LuYY,WangYG,DaiB,ZhuQ(通讯作者),“Anovelfluorogenicprobeformonoamineoxidaseassays”ChineseChem.Lett.2008,19(8),947-950.14.ZhuQ(通讯作者),FanA,WangYS,ZhuXQ,WangZ,WuMH,andZhengYG,“Novelsensitivehigh-throughputscreeningstrategyfornitrilase-producingstrains”Appl.Envirom.Micro.2007,73(19),6053-6057.15.ZhuQ(通讯作者),TrembalyMS,“Allylandbenzyliodidesbytheanomalousactionofiodotrimethylsilane,Bioorg.Med.Chem.Lett.2006,16(24),6170-6172.16.ZhuQ,GirishA,ChattopadhayaS,YaoSQ,“Developingnovelactivity-basedfluorescentprobesthattargetdifferentclassesofproteases”Chem.Commun.2004,1512-1513.17.TremblayMS,ZhuQ,MartíAA,DyerS,HalimM,JockuschS,TurroNJ,SamesD,“Phosphorylationstate-responsivelanthanidepeptideconjugates:aluminescenceswitchbasedonreversiblecomplexreorganization”,OrganicLett.2006,8(13),2723-2726.18.YeoSYD,SrinivasanR,UttamchandaniM,ChenGYJ,ZhuQ,YaoSQ,“Cell-permeablesmallmoleculeprobesforsite-specificlabelingofproteins.”Chem.Commun.2003,2870-2871.19.LueRYP,ChenGYJ,HuY,UttamchandaniM,ZhuQ,YaoSQ,“Versatileproteinbiotinylationstrategiesforpotentialhigh-throughputproteomics”J.Am.Chem.Soc.2004,126,1056-1062.20.ZhuQ,HuangX,Grace,YJChen,YaoSQ,“Designandsynthesisoffluorogenicsubstratesthattargetproteinphosphatases”TetrahedronLett.2004,707-710.21.ZhuQ,MaheshUttamchandani,MarieL.Lesaicherre,DongboLi,ShaoQYao,“AnEnzymaticProfilingSysteminaSmall-moleculemicroarray”Org.Lett.2003,5(8),1257-1260.22.ZhuQ,HuangX,Grace,YJChen,YaoSQ,“Activitybasedfluorescentprobesthattargetphosphatases”TetrahedronLett.2003,44(13),2669-2672.23.ZhuQ,LiDB,Uttamchandani,M,YaoSQ,“Facilesynthesisof7-amino-4-carbonoylmethylcoumarin(ACC)-containingsolidsupportsandtheircorrespondingfluorogenicproteasesubstrates”Bioorg.Med.Chem.Lett.2003,13(6),1033-1036.24.ChenGYJ,UttamchandaniM,ZhuQ,WangG,YaoSQ,“Deveolpinganovelstrategyfordetectionofenzymaticactivitiesonaproteinarray”ChemBiochem,2003,4(4),336-339.25.Marie-LaureL,RinaYP,Grace,YJChen,ZhuQ,Yao,SQ,“Intein-mediatedbiotinylationofproteinsanditsapplicationinaproteinmicroarray”J.Am.Chem.Soc.2002,124(8),8768-8769.26.ZhuQ,YaoSQ,“CombinatorialdiscoveryofnovelfluorescentdyesbasedonDapoxyl^TM”TetrahedronLett.2002,43(29),5083-5086.论著与教材：1.最新农药合成与剖析，科学出版社，2011，副主编科研成果及专利：一种腈水解酶活性的荧光检测方法，ZL200610053636.8一种环氧化物水解酶产生菌的荧光检测方法，ZL200710071212.9一种单胺氧化酶活性的荧光检测方法，ZL200710067620.7酰胺类化合物在制备单胺氧化酶抑制剂中的应用及化合物，ZL201010504104.8研究生培养等教学情况：自2006年起，共招收研究生23名，毕业14名。奖励和荣誉：其它：