姓名：占扎君工作部门：药学院性别：男技术职称：教授最高学位：博士民族：汉籍贯：浙江杭州联系方式：18957103773Email:zjunpr@zjut.edu.cn电话：0571-88871975主要研究方向：天然药物化学（天然活性分子的分离鉴定、结构优化及其在药物中的应用开发）简历：主要从事天然药物化学领域的研究，包括天然活性分子的分离鉴定、结构优化及其在药物中的应用开发。目前已完成了30余种植物、微生物的活性成分研究工作，从中获得化合物500余个，其中新化合物150余个，并发现10余个具有重要生物活性的天然小分子，如乳腺癌抑制活性为紫杉醇100倍的化合物Ten，a-糖苷酶抑制活性为II型糖尿病治疗药物阿卡波糖3倍的ZX02等，其中1个已完成临床前药效学及急性毒性研究，目前正与企业商谈合作完成化药1.1类新药临床前资料研究工作。经过多年学习与交流，本人已熟悉新药临床前申报资料的准备与申报流程。迄今为止，已主持或参与项目10项，其中国家级1项，省部级4项，厅局级4项，企业横向1项。已发表SCI收录论文58篇，其中第一作者或通讯作者42篇，影响因子最高的为10.18，论文已被引用240余次，单篇引用次数最高的为36次。已申报专利6项，已授权4项。研究（情况）项目：1.分子烙印技术快速识别分离狗牙花属乙酰胆碱酯酶抑制活性的生物碱，国家自然科学基金(20702049)，19万，2008.1-2010.12，主持。2.利用分子烙印技术有效识别分离海洋资源中靶向抗肿瘤药物—酪氨酸激酶抑制剂的研究，浙江省自然科学基金(Y206825)，6万，2007.1-2008.12，主持。3.桦褐孔菌的化学成分研究，杭州华东医药集团生物工程研究所有限公司(横向)，8万，2013.7-2015.8，主持。4.传统中药锦灯笼化学成分及抗菌活性研究，浙江省教育厅(20051411)，1万，2005.7-2006.7，主持。发表的论文、专著、教材：(1)Wei-GuangShan,Li-WenZhang,Jia-GuiXiang,Zha-JunZhan*,Naturalfriedelanes,Chem.Biovers.,2013,10(8),1392-1434.(2)You-MinYing,Wei-GuanShang,Li-WenZhang,Zha-JunZhan*,CeriponolsA-K,tremulanesesquitepenesfromCeriporialacerateHS-ZJUT-C13A,afungalendophyteofHuperziaserrata,Phytochemistry,2013,95,360-367.(3)Jia-GuiXiang,Wei-GuangShan,Dong-ELiang,You-MinYing,Li-SheGan,Zha-JunZhan*,N-BearingfuranonederivativesfromanendophyticfungusinHuperziaserrata,Helv.Chim.Acta,2013,96(3),997-1003.(4)Wei-GuangShan,Ling-LingShi,You-MinYing,Xiao-RongHou,Zha-JunZhan*,AnewprenylatedstilbenederivativefromtherootsofCudraniatricuspidata,J.Chem.Res.,2013,(5),285-286.(5)You-MinYing,Wei-GuanShang,Wen-HongLiu,Zha-JunZhan*,AlkaloidsandnucleosidederivativesfromafungalendophyteofHuperziaserrata,Chem.Nat.Comp.,2013,49(1),184-186.(6)You-MinYing,Wei-GuanShang,Wen-HongLiu,Zha-JunZhan*,StudiesonthemetabolitesofafungalendophytePenicilliumsp.HS-5fromHuperziaserrata,AsianJ.Chem.,2013,25(3),1208-1210.(7)Zha-JunZhan,Yan-TaoWen,Feng-YuRen,Gui-WeiRao,Wei-GuangShan,Cheng-PingLi,DiterpenoidsandadiarylheptanoidfromHedychiumcoronariumwithsignificantanti-angiogenicandcytotoxicactivities,Chem.Biovers.,2012,9(12),2754-2760.(8)Wei-GuangShan,Tian-SongLin,Hai-NingYu,YanChen,Zha-JunZhan*,PolyprenylatedxanthonesandbenzophenonesfromthebarkofGarciniaOblongifolia,Helv.Chim.Acta,2012,95(8),1442-1448.(9)Wei-GuangShan,Dong-ELiang,You-MingYing,Zha-JunZhan*,TwonewtremulanesesquiterpenoidsfromCeriporialacerate,anendophyticfungusofHuperziaserrata,J.Chem.Res.,2012,(6),365-367.(10)Wei-GuangShan,XiaoLiu,Lie-FengMa,Zha-JunZhan*,NewpolyhydroxypregnaneglycosidesfromCynanchumotophyllum,J.Chem.Res.,2012,(1),38-40.(11)Wei-GuanShang,Feng-YunRen,You-MinYing,Cui-PingTong,Zha-JunZhan*,AnewlycopodinealkaloidfromHuperziaserrata,J.Chem.Res.,2012,(1),15-16.(12)Ling-JunHu,Zha-JunZhan,MinLei,Li-HongHu,Facileandgreenmethodforthesynthesisof4-amino-1,2-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitrilescatalysedbyammoniumacetate,J.Chem.Res.,2012,(12),738-739.(13)Zha-JunZhan,You-MinYing,Lie-FengMa,Wei-GuangShan,Naturaldisesquiterpenoids,Nat.Prod.Rep.,2011,28(3),594-628.(14)Lie-FengMa,Wei-GuangShan,Zha-JunZhan*,PolyhydroxypregnaneglycosidesfromtherootsofCynanchumotophyllum,Helv.Chim.Acta,2011,94(12),2272-2282.(15)Wei-GuangShan,Xiao-XiaoChen,You-Min,Ying,Zha-JunZhan^*,SesquiterpenoidsfromFusariumsp.,anendophyticfungusinAgriminiapilosa,Helv.Chim.Acta,2011,94(7),1254-1259.(16)Zha-JunZhan,Jian-PingJin,You-Min,Ying,Wei-GuangShan,FuranonederivativesfromAspergillussp.XW-12,anendophyticfungusinHuperziaserrata,Helv.Chim.Acta,2011,94(8),1454-1458.(17)Yan-PingWen,Xue-ChangWu,YiTeng,Chao-DongQian,Zha-JunZhan,Yu-HuaZhao,OuLi,Identificationandanalysisofthegeneclusterinvolvedinbiosynthesisofpaenibactin,acatecholatesiderophoreproducedbyPaenibacilluselgiiB69,Environ.Microb.,2011,13(10),2726–2737.(18)RuiDing,Xue-ChangWu,Chao-DongQian,YiTengOuLi,Zhan-JunZhan,Yu-Hua,Zhao,IsolationandidentificationoflipopeptideantibioticsfromPaenibacilluselgiiB69withinhibitoryactivityagainstmethicillin-resistantStaphylococcusaureus,J.Microbiol.,2011,49(6),942-949.(19)Wen-HongLiu,JieHe,Zhi-ShanDing,Zhong-ChengSong,Zha-JunZhan^*,ActaCryst.E,2011,O730.(20)Xue-ChangWu,Chao-DongQian,Hai-HuanFang,Yan-PingWen,Jian-YingZhou,Zha-JunZhan,RuiDing,OuL,Hai-ChunGao,Paenimacrolidin,anovelmacrolideantibioticfromPaenibacillussp.F6-B70activeagainstmethicillin-resistantStaphylococcusaureus,MicrobialBiotechnol.,2011,4(4),491–502.(21)You-MinYing,Zha-JunZhan,Zhi-ShanDing,Wei-GuangShan,BioactivemetabolitesfromPenicilliumsp.P-1,afungalendophyteinHuperziaserrata,Chem.Nat.Compd.,2011,47(4),541-544.(22)Zha-JunZhan,QiYu,Zhan-LiWang,Wei-GuanShang,IndolealkaloidsfromErvatamiahainanensiswithpotentacetylcholinesteraseinhibitionactivities,Bioorg.Med.Chem.Lett.,2010,20(21),6185-6187.(23)Zha-JunZhan,Hong-Lin,Bian,Jian-WeiWang,Wei-GuangShan,Synthesisofphysostigmineanaloguesandevaluationoftheiranticholinesteraseactivities,Bioorg.Med.Chem.Lett.,2010,20(5),1532-1534.(24)Wei-GuangShan,You-MinYing,Hai-NingYu,Wen-HongLiu,Zha-JunZhan^*,DiketopiperazinealkaloidsfromPenicilliumspp.HS-3,anendophyticfungusinHuperziaserrata,Helv.Chim.Acta,2010,93(4),722-776.(25)Zha-JunZhan,You-Min,Ying,Fu-YuZhang,Cheng-PingLi,Wei-GuangShan,ThreenewilludalanesequiterpenoidsfromPterissemipinnata,Helv.Chim.Acta,2010,93(3),550-554.(26)Gui-WeiRao,Zha-JunZhan,Cheng-PingLi,Wei-GuangShan,AnovelsesquiterpenoidglucosidefromHedyosmumorientale,J.Chem.Res.,2010,(12),697-698.(27)Zha-JunZhan,Zhi-GangZhou,Wei-GuangShan,PreparationandcharacterizationofCu,Zn-superoxidedismutasecovalentlymodifiedbypolyunsaturatedfattyacidsBiochemistry,2009,74(11),1266-1269.(28)Zha-JunZhan,Gui-WeiRao,Xiao-RongHou,Cheng-PingLi,Wei-GuangShan,AlkaloidsfromtheleavesandstemsofDaphniphyllumcalycinum,Helv.Chim.Acta,2009,92(8),1562-1567.(29)Zha-JunZhan,Xiao-YongZhang,Xiao-RongHou,Cheng-PingLi,Wei-GuangShan,NewditerpenoidsfromTinosporacapillipes,Helv.Chim.Acta,2009,92(4),790-794.(30)Zha-JunZhan,Li-WenZhang,Wei-GuangShan,Ervahainanmine,anewindolealkaloidfromthestemsofErvatamiahainanensis,J.Chem.Res.,2009,(7),416-417.(31)Zha-JunZhan,LanTang,Wei-GuangShanAnewtTriterpeneglycosidefromPremnamicrophylla,Chem.Nat.Compd.,2009,45(2),197-199.(32)Zha-JunZhan,Fu-YuZhang,Cheng-PingLi,Wei-GuangShan,Anovelent-kauranediterpenoidfromPterissemipinnata,J.Chem.Res.,2009,(3),149-150.(33)Zha-JunZhan,Lie-FengMa,Xiao-YongZhang,Wei-GuangShan,Anewhetisine-typediterpenoidalkaloidfromAconitumcoreanum,J.Chem.Res.,2009,(1),20-21.(34)Zha-JunZhan,Hong-LinBian,Wei-GuangShan,AlisolC23-acetatefromtherhizomeofAlismaorientale,ActaCryst.E,2008,2331.(35)Zha-JunZhan^*,Xiao-RongHou,SesquiterpenoidalkaloidfromAcroptilonrepens,NatProdRes.,2008,22(3),222-226.(36)LanTang,Gui-WeiRao,Zha-JunZhan,Wei-GuangShan,AnovelalkaloidfromtheseedsofDaphniphyllumcalycinum,J.Chem.Res.,2008,(4),203-204.(37)Zha-JunZhan,Cheng-PingLi,Wei-GuangShan,AnewsesquiterpenefromtheseedsofPhysalisalkekengiL.var.franchi,J.Chem.Res.,2007,(1),38-39.(38)JieQian,Zha-JunZhan*,NovelalkaloidsfromStemonasessilifolia,Helv.Chim.Acta,2007,90(2),326-331.(39)Lin-MeiShi,Zha-JunZhan*,Structuralrevisionof19,20-expoxycytochalasinDanditscytotoxicactivity,J.Chem.Res.,2007,(3),114-115.(40)Wen-HongLiu,Yun-FenHua,Zha-JunZhan*,AnewalkaloidfromDendrobiummoniliforme,J.Chem.Res.,2007,(6),317-318.(41)Li-SheGan,Zha-JunZhan,Sheng-PingYang,Jian-MinYue,TwonewterpenoidglycosidesfromAsterflaccidus,J.AsianNat.Prod.Res.,2006,8(7),589-594.(42)XinChen,Zha-JunZhan,Jian-MinYue,SesquiterpenoidsfromVernoniacinerea,NatProdRes.,2006,20(1),31-35.(43)Chen-QiFan,Xing-ZuZhu,Zha-JunZhan,Xin-QuanJi,HuiLi,Jian-MinYue,LignansfromSaussureaconicaandtheirNOproductionsuppressingactivity,PlantaMedica,2006,72(4),590-595.(44)Zha-JunZhan,Chuan-RuiZhang,Jian-MinYue,CaldaphnidinesA–F,sixnewDaphniphyllumalkaloidsfromDaphniphyllumcalycinum,Tetrahedron,2005,61,11038–11045.(45)Shang-GaoLiao,Zha-JunZhan,Sheng-PingYang,Jian-MinYue,LathyranoicacidA:firstsecolathyranediterpenoidinnaturefromEuphorbialathyrisOrg.Lett.,2005,7(7),1379-1382.(46)Zha-JunZhan,Cheng-QiFan,JianDing,Jian-MinYue,NovelditerpenoidswithpotentinhibitoryactivityagainstendotheliumcellHMECandcytotoxicactivitiesfromawellknownTCMplantDaphnegenkwa,Bioorg.Med.Chem.,2005,13(3),645-655.(47)XinChen,Zha-JunZhan,Xiong-WenZhan,JianDing,Jian-MinYue,SesquiterpenelactoneswithpotentcytotoxicactivitiesfromVernoniachinensis,PlantaMedica,2005,71(10),949-955.(48)XinChen,Zha-JunZhan,Jian-MinYue,LongistyllumphyllinesA-C,threealkaloidsfromDaphniphyllumlongistylum,Helv.Chim.Acta,2005,88(4),854-860.(49)Zha-JunZhan,Sheng-PingYang,Jian-MinYue,PaxdaphnidinesAandB,novelpenta-andtetracyclicalkaloidsfromDaphniphyllumpaxianum,J.Org.Chem.,2004,69(5),1726-1729.(50)XinChen,Zha-JunZhan,Jian-MinYue,OldhamiphyllineA:anovelhexacyclicalkaloidfromDaphniphyllumoldhami,Chemi.Biodiver.,2004,1(12),1513-1518.(51)Chen-QiFan,Zha-JunZhan,HuiLi;Jian-MinYue,Eudesmane-typesesquiterpenesderiativesfromSaussureaconica,Helv.Chim.Acta,2004,87(6),1446-1451.(52)YingXiang,Sheng-PingYang,Zha-JunZhan,Jian-MinYue,TerpenoidsandphenolsfromTaiwaniaflousiana,ActaBot.Sin.,2004,46(8),1002-1008.(53)Zha-JunZhan,Jian-MinYue,Newglycosphigolipidsfromthefunguscatathelasmavetricosa,J.Nat.Prod.,2003,66(7),1013-1016.(54)Zha-JunZhan,Jian-MinYue,NewglycerglycolipidandceramidefromPremnamicrophylla,Lipids,2003,38(12),1299-1303.(55)Zha-JunZhan,YingWang,Sheng-PingYang,Jian-MinYue,SteroidsfromthefungusPleurotusostreatus,ActaBot.Sin.,2003,45(6),753-756.(56)Zha-JunZhan,Hang-DongSun,Hou-minWu,Jian-MinYue,ChemicalconstituentsfromthefungusEngleromycesgoetzei,ActaBot.Sin.,2003,45(2),248-252.(57)《天然药物化学》，浙江大学出版社，2011，编委。科研成果及专利：(1)占扎君，单伟光，王建伟，乙酰胆碱酯酶抑制剂的发现及优化，浙江高校优秀科研成果奖，二等奖，2011。(2)单伟光，叶珊珊，王建伟，占扎君，唐岚，侯晓容，于海宁，一种硫酸胍基丁胺的合成方法，申请号：CN200910154924.6，授权公告号：CN101717352B。(3)单伟光，叶珊珊，王建伟，占扎君，唐岚，侯晓蓉，于海宁，一种1,4-丁二胺的合成方法，申请号：CN200910155160.2，授权公告号：CN101735067B。(4)单伟光，唐岚，单海峰，占扎君，一种葫芦素B的提取分离方法，申请号：CN200910154837.0，授权公告号：CN101759746B。(5)单伟光，唐岚，李西秦，杨旭，侯晓蓉，王建伟，李成平，占扎君，于海宁，王占黎，一种抗抑郁的中药组合物及其应用，申请号：CN201010223090.2，专利号：ZL201010223090.2。研究生培养等教学情况：主讲高等天然药物化学；已培养硕士研究生3名，另外协助指导博士研究生2名、硕士研究生11名。奖励和荣誉：(1)浙江省“151人才”第三层次，2007。(2)浙江省高校中青年学科带头人,2013。(3)浙江工业大学“我心目中的好导师”十佳导师，2011。其它：